Results 141 to 150 of about 14,649 (249)

Correction to "Enantioselective Synthesis of 2,3-Disubstituted Azetidines via Copper-Catalyzed Boryl Allylation of Azetines". [PDF]

J Am Chem Soc
Zhu M, Sun J.
europepmc   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Overriding Stereochemical Outcomes in Cyclase Phase Total Synthesis: Enantioselective Synthesis of Habiterpenol and Dasyscyphin A. [PDF]

J Am Chem Soc
Wu L, Nguyen LH, Yan L, Yin H, Mizuno N, Schuppe AW.   +5 more
europepmc   +1 more source

Enzymatic Catalysis of Biodiesel—A Critical Perspective

WIREs Energy and Environment, Volume 15, Issue 3, September 2026.
This figure illustrates the main advantages and drawbacks of enzymatic biodiesel production, highlighting its potential as a sustainable alternative to chemical routes and noting economic and technical barriers that must be addressed to enable large‐scale adoption in the global energy transition. ABSTRACT Biodiesel, a renewable alternative to petroleum
Jéssica Beatriz R. A. Miranda, Jackson Milano, Maura H. Sugai‐Guerios   +2 more
wiley   +1 more source

Enantioselective Synthesis of Axially Chiral Diaryl Ethers via Rhodium‐Catalyzed [2 + 2 + 2] Cycloaddition

Angewandte Chemie, Volume 138, Issue 32, 3 August 2026.
An enantioselective rhodium‐catalyzed [2 + 2 + 2] cycloaddition enables the synthesis of axially chiral diaryl ethers. Carbonyl coordination ensures high reactivity and regioselectivity, affording products bearing up to four stereogenic axes with good enantio‐ and diastereoselectivity.
Yu Sato, Julong Jiang, Kairi Yamashiro, Ken Tanaka   +3 more
wiley   +2 more sources

Enantioselective Synthesis of 2-Oxabicyclo[2.1.1]hexanes and Bicyclo[2.1.1]hexanes via Catalytic Asymmetric Intramolecular Photocycloadditions. [PDF]

Nat Commun
Tian D, Qu C, Cao S, Yu B, Zhao X, Zhang J, Jiang Z.   +6 more
europepmc   +1 more source

Exploiting the Reverse Function of Ene‐Reductase Enzymes in the Continuous Flow Synthesis of Naphthols From Tetralones

Advanced Synthesis &Catalysis, Volume 368, Issue 16, 18 August 2026.
The development and optimization of a continuous flow method for the use of ERED enzymes in the reverse mode is presented to convert tetralones into naphthols using air as the terminal oxidant. Both solution‐phase and the immobilized enzyme were explored along with different reactor configurations leading to product yields of up to 83% in short ...
Ruairí Bannon, Philip Jamieson, Kathryn Yeow, Megan Smyth, Scott Wharry, Thomas S. Moody, Marcus Baumann   +6 more
wiley   +1 more source

Asymmetric Iron‐Catalyzed Vicinal C(sp3)─H Diamination of Carboxylic Acids

Angewandte Chemie, Volume 138, Issue 32, 3 August 2026.
An iron‐catalyzed vicinal α,β‐C(sp3)─H diamination of readily available carboxylic acids furnishes chiral α,β‐diamino acids in a single pot with high regio‐, diastereo‐, and enantioselectivity (up to >20:1 dr and >99% ee). ABSTRACT The direct construction of chiral 1,2‐diamines through the stereoselective functionalization of two vicinal C(sp3)─H bonds
Bing Zhou, Yuan Zheng, Xiulan Xie, Marcel Hemming, Sergei I. Ivlev, Eric Meggers   +5 more
wiley   +2 more sources

Catalytic enantioselective synthesis of selenium-containing atropisomers via C-Se bond formations. [PDF]

Beilstein J Org Chem
Gao QS, Wei ZW, Chen ZM.
europepmc   +1 more source

Fragmentation of Vancoresmycin Reveals a Strong Dependence on Global Molecular Architecture for Antibacterial Activity

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Fragmentation of the natural product vancoresmycin reveals an essential role of global architecture for biological potency. Vancoresmycin is a structurally complex tetramic‐acid‐containing natural product with potent activity against Gram‐positive bacteria, yet its structure–activity relationships remain poorly defined.
Max Schönenbroicher, Florian Heppner, Maximilian Seul, Simon Morgenschweis, Aia Ali Abdelrahman, Eva Fahr, Niklas Holstein, Anna Müller, Dirk Menche   +8 more
wiley   +1 more source