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Engineering the Enantioselectivity of Yeast Old Yellow Enzyme OYE2y in Asymmetric Reduction of (E/Z)-Citral to (R)-Citronellal [PDF]
Molecules, 2019 The members of the Old Yellow Enzyme (OYE) family are capable of catalyzing the asymmetric reduction of (E/Z)-citral to (R)-citronellal—a key intermediate in the synthesis of L-menthol. The applications of OYE-mediated biotransformation are usually
Xiangxian Ying +9 more
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A Comparative Study of C2-Symmetric and C1-Symmetric Hydroxamic Acids in Vanadium-Catalyzed Asymmetric Epoxidation of Allylic Alcohols [PDF]
MoleculesHydroxamic acids are emerging as versatile chiral ligands for metal-catalyzed asymmetric oxidations due to their tunable electronic and steric environments.
Marco Valtierra-Galván +6 more
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Rational design of enzyme activity and enantioselectivity
Frontiers in Bioengineering and Biotechnology, 2023 The strategy of rational design to engineer enzymes is to predict the potential mutants based on the understanding of the relationships between protein structure and function, and subsequently introduce the mutations using the site-directed mutagenesis ...
Zhongdi Song +4 more
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Molecules, 2021 Enzymes, receptors, and other binding molecules in biological processes can recognize enantiomers as different molecular entities, due to their different dissociation constants, leading to diverse responses in biological processes. Enantioselectivity can
Maria Miguel Coelho +3 more
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Enantioselective protonation [PDF]
Nature Chemistry, 2009 Enantioselective protonation is a common process in biosynthetic sequences. The decarboxylase and esterase enzymes that effect this valuable transformation are able to control both the steric environment around the proton acceptor (typically an enolate) and the proton donor (typically a thiol).
Mohr, Justin T. +2 more
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Supramolecular Chiral Nanozymes with High and Switchable Enantioselectivity
Small Structures, 2023 Understanding and manipulation of catalytic enantioselectivity have emerged as a paramount challenge for decades. Inspired by nature, nanozymes with enantioselectivity have been designed.
Chu Wang +7 more
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Comprehensive Analysis of a Yeast Lipase Family in the Yarrowia Clade. [PDF]
PLoS ONE, 2015 Lipases are currently the subject of intensive studies due to their large range of industrial applications. The Lip2p lipase from the yeast Yarrowia lipolytica (YlLIP2) was recently shown to be a good candidate for different biotechnological applications.
Muchalin Meunchan +5 more
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Green Synthesis and Catalysis, 2021 Biocatalysts with tailor-made or controllable stereoselectivity are valuable and highly desired in the precision synthesis of chiral compounds. Most lipases display excellent (R)-enantioselectivity for various sec-alcohols.
Danyang Li +5 more
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Enantioselective Tsuji Allylations [PDF]
Chemistry – An Asian Journal, 2007 AbstractThe family of allylation reactions developed by Tsuji in the 1980s are capable of generating tertiary and quaternary carbon stereocenters from several synthetic precursors. Despite the utility of these transformations, they have seen little use in the synthesis of natural products.
Mohr, Justin T., Stoltz, Brian M.
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Nature Communications, 2023 Enantioselectivity of helical aggregation is conventionally directed either by its homochiral ingredients or by introduction of chiral catalysis. The fundamental question, then, is whether helical aggregation that consists only of achiral components can ...
Hiroki Aizawa +7 more
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