Results 121 to 130 of about 39,817 (294)

Bayesian Meta‐Learning for Few‐Shot Reaction Outcome Prediction of Asymmetric Hydrogenation of Olefins

Angewandte Chemie, EarlyView.
A Bayesian meta‐learning framework is proposed for reaction outcome prediction in low‐data settings. It utilizes a literature‐mined dataset on asymmetric hydrogenation of olefins to build a pre‐trained model. This meta‐model is shown to return better predictions as compared to single‐tasks methods, such as random forest and graph neural networks, given
Sukriti Singh, José Miguel Hernández‐Lobato   +1 more
wiley   +2 more sources

Enantioselective Aminosilylation of Alkenes by Palladium/Ming‐Phos‐Catalyzed Tandem Narasaka–Heck/Silylation Reaction

Advanced Science
A Pd‐catalyzed enantioselective aminosilylation of alkenes via tandem Aza‐Heck/silylation reaction under Pd/Sadphos catalysis is disclosed. A wide array of oxime esters and silicon reagents are tolerated, furnishing the chiral pyrrolines bearing one ...
Kangning Cao, Jie Han, Wenshao Ye, Dejun Hu, Zihao Ye, Junfeng Yang, Junliang Zhang, Fener Chen   +7 more
doaj   +1 more source

Optimization of the asymmetric synthesis of (S)-1-phenylethanol using Ispir bean as whole-cell biocatalyst

Green Processing and Synthesis, 2019
In this study, enantiomerically pure (S)-1-phenylethanol was produced via asymmetric bioreduction of acetophenone. Ispir bean (Phaseolus vulgaris) was used as an alcohol dehydrogenase (ADH) source since whole cells are cheaper than isolated enzymes ...
Atak Gunay Baydar, Bayraktar Emine, Mehmetoglu Ülkü   +2 more
doaj   +1 more source

Chiral near-field manipulation in Au-GaAs hybrid hexagonal nanowires [PDF]

, 2017
We demonstrate the control of enhanced chiral field distribution at the surface of hybrid metallo-dielectric nanostructures composed of self-assembled vertical hexagonal GaAs-based nanowires having three of the six sidewalls covered with Au. We show that
Belardini, Alessandro, Centini, Marco, Hakkarainen, Teemu, Leahu, Grigore, Petronijevic, Emilija, Sibilia, Concetta   +5 more
core   +2 more sources

Synthesis of a BINOL‐Derived Sulfide Catalyst Bearing a Diphenylmethanol Unit and Its Application in Asymmetric Bromolactonizations

Asian Journal of Organic Chemistry, EarlyView.
The excellent catalytic performance of a BINOL‐derived sulfide catalyst bearing a diphenylmethanol unit was demonstrated in the highly enantioselective synthesis of γ‐butyrolactones via bromolactonization. Abstract A BINOL‐derived sulfide catalyst bearing a diphenylmethanol unit was prepared.
Yasuaki Furuya, Ryuichi Nishiyori, Seiji Shirakawa   +2 more
wiley   +1 more source

Manganese‐Catalyzed Enantioselective Dearomative Epoxidation of Naphthalenes with Aqueous Hydrogen Peroxide

Angewandte Chemie, EarlyView.
The enantioselective epoxidation of naphthalenes into their corresponding arene oxides with aqueous hydrogen peroxide is described. The reaction combines dearomatization with installation of chemically versatile functionality in an enantioselective manner.
Najoua Choukairi Afailal, Siu‐Chung Chan, Miquel Costas   +2 more
wiley   +2 more sources

Machine learning-assisted amidase-catalytic enantioselectivity prediction and rational design of variants for improving enantioselectivity

Nature Communications
Biocatalysis is an attractive approach for the synthesis of chiral pharmaceuticals and fine chemicals, but assessing and/or improving the enantioselectivity of biocatalyst towards target substrates is often time and resource intensive.
Zi-Lin Li, Shuxin Pei, Ziying Chen, Teng-Yu Huang, Xu-Dong Wang, Lin Shen, Xuebo Chen, Qi-Qiang Wang, De-Xian Wang, Yu-Fei Ao   +9 more
doaj   +1 more source

Enantioconvergent catalysis

Beilstein Journal of Organic Chemistry, 2016
An enantioconvergent catalytic process has the potential to convert a racemic starting material to a single highly enantioenriched product with a maximum yield of 100%.
Justin T. Mohr, Jared T. Moore, Brian M. Stoltz   +2 more
doaj   +1 more source

P450BM3-Catalyzed Oxidations Employing Dual Functional Small Molecules [PDF]

, 2019
A set of dual functional small molecules (DFSMs) containing different amino acids has been synthesized and employed together with three different variants of the cytochrome P450 monooxygenase P450BM3 from Bacillus megaterium in H2O2-dependent oxidation
Girhard, Marco, Gonzalo Calvo, Gonzalo de, Hollmann, Frank, Tieves, Florian, Urlacher, Vlada B., Willot, Sébastien Jean-Paul   +5 more
core   +1 more source

Solvent‐Directed Handedness in a Chirally Twisted Tetrakisporphyrin Macrocycle

Asian Journal of Organic Chemistry, EarlyView.
A chirally twisted tetrakisporphyrin macrocycle was synthesized by incorporating a chiral dioxolane into a tetrakisporphyrin macrocycle. The solvent type influenced the preferred handedness of the twisted conformation. Circular dichroism measurements and computational analyses determined the handedness of the conformers in solvents toluene and ...
Kouta Tanabe, Naoyuki Hisano, Takeharu Haino   +2 more
wiley   +1 more source