Results 11 to 20 of about 149,811 (326)

Nonheme Fe Enzyme-Catalyzed Enantiodivergent Nitrogen Migration: Directed Evolution and Computational Study of Isopenicillin N Synthases for Biocatalytic Synthesis of Arylglycines. [PDF]

Angew Chem Int Ed Engl
Nonheme Fe enzyme isopenicillin N synthase was reprogrammed and evolved as an efficient nitrogen migratase IPNSNim, converting diverse azanyl esters to valuable l‐arylglycines with up to 16 000 TTN and 97:3 e.r. IPNSNim and ACCONim allowed enantiodivergent preparation of both l‐ and d‐arylglycines.
Lin K, Zhao LP, Wang S, Liu H, Zhang Y, Mai BK, Liu P, Yang Y.   +7 more
europepmc   +3 more sources

Computational Study of Mechanism and Enantioselectivity of Imine Reductase from Amycolatopsis orientalis

ChemistryOpen, 2022
Imine reductases (IREDs) are NADPH‐dependent enzymes (NADPH=nicotinamide adenine dinucleotide phosphate) that catalyze the reduction of imines to amines.
Dr. Mario Prejanò, Prof. Dr. Xiang Sheng, Prof. Dr. Fahmi Himo   +2 more
doaj   +1 more source

Engineering of Yeast Old Yellow Enzyme OYE3 Enables Its Capability Discriminating of (E)-Citral and (Z)-Citral

Molecules, 2021
The importance of yeast old yellow enzymes is increasingly recognized for direct asymmetric reduction of (E/Z)-citral to (R)-citronellal. As one of the most performing old yellow enzymes, the enzyme OYE3 from Saccharomyces cerevisiae S288C exhibited ...
Tairan Wang, Ran Wei, Yingting Feng, Lijun Jin, Yunpeng Jia, Duxia Yang, Zuonan Liang, Mengge Han, Xia Li, Chenze Lu, Xiangxian Ying   +10 more
doaj   +1 more source

Enantioselective Self-Replicators

Journal of the American Chemical Society, 2023
Self-replicating molecules provide a simple approach for investigating fundamental processes in scenarios of the emergence of life. Although homochirality is an important aspect of life and of how it emerged, the effects of chirality on self-replicators have received only little attention so far.
Yang, Shuo, Geiger, Yannick, Geerts, Marc, Eleveld, Marcel J., Kiani, Armin, Otto, Sijbren   +5 more
openaire   +3 more sources

Redesign of a short-chain dehydrogenase/reductase for asymmetric synthesis of ethyl (R)-2-hydroxy-4-phenylbutanoate based on per-residue free energy decomposition and sequence conservatism analysis

Green Synthesis and Catalysis, 2020
As an important building block for the synthesis of angiotensin-converting enzyme inhibitors, ethyl (R)-2-hydroxyl-4-phenylbutanoate [(R)-HPBE] has attracted increasing attention.
Bingmei Su, Lian Xu, Xinqi Xu, Lichao Wang, Aipeng Li, Juan Lin, Lidan Ye, Hongwei Yu   +7 more
doaj   +1 more source

Enantioselectivity-Evaluation of Chiral Copper(II) Complexes Coordinated by Novel Chiral Tetradentate Ligands for Free Amino Acids by Mass Spectrometry Coupled With the Isotopically Labeled Enantiomer Method

Frontiers in Chemistry, 2020
A series of copper(II) complexes with chiral tetradentate ligands, N,N′-ethylene- bis(S-amino acid methyl amide or methyl ester) prepared from S-alanine, S-phenylalanine, S-valine or S-proline, was generated in methanol.
Takashi Nakakoji, Kaori Yoshino, Kazuki Izutsu, Hirofumi Sato, Hiroyuki Miyake, Eiko Mieda, Satoshi Shinoda, Hiroshi Tsukube, Hideya Kawasaki, Ryuichi Arakawa, Daisuke Ono, Motohiro Shizuma   +11 more
doaj   +1 more source

Holistic Prediction of Enantioselectivity in Asymmetric Catalysis

Nature, 2019
When faced with unfamiliar reaction space, synthetic chemists typically apply the reported conditions (reagents, catalyst, solvent and additives) of a successful reaction to a desired, closely related reaction using a new substrate type.
Jolene P. Reid, M. Sigman
semanticscholar   +1 more source

Organocatalyzed Enantioselective Fluorocyclizations

Angewandte Chemie International Edition, 2011
Enantioenriched fluorinated heterocycles can be prepared through fluorocyclizations of prochiral indoles (see scheme; Ts=tosyl, Bn=benzyl, Boc=tert-butoxycarbonyl). More than twenty examples for this cascade fluorination-cyclization, which is catalyzed by cinchona alkaloids and employs N-fluorobenzenesulfonimide as the electrophilic fluorine source ...
Lozano, O, Blessley, G, Martinez del Campo, T, Thompson, A, Giuffredi, G, Bettati, M, Walker, M, Borman, R, Gouverneur, V   +8 more
openaire   +2 more sources

Flexible Enantioselectivity of Tryptophanase Attributable to Benzene Ring in Heterocyclic Moiety of D-Tryptophan

Life, 2012
The invariance principle of enzyme enantioselectivity must be absolute because it is absolutely essential to the homochiral biological world. Most enzymes are strictly enantioselective, and tryptophanase is one of the enzymes with extreme absolute ...
Akihiko Shimada, Haruka Ozaki
doaj   +1 more source

Enantioselective Synthesis of 2,2-Disubstituted Terminal Epoxides via Catalytic Asymmetric Corey-Chaykovsky Epoxidation of Ketones

Molecules, 2012
Catalytic asymmetric Corey-Chaykovsky epoxidation of various ketones with dimethyloxosulfonium methylide using a heterobimetallic La-Li3-BINOL complex (LLB) is described.
Shigeki Matsunaga, Masakatsu Shibasaki, Toshihiko Sone, Akitake Yamaguchi   +3 more
doaj   +1 more source