Results 211 to 220 of about 149,811 (326)

Brønsted acid catalyzed enantioselective inter and intramolecular α-amidoalkylation reactions in the synthesis of isoquinoline derivatives

, 2016
Eider Aranzamendi Uruburu, Nuria Sotomayor, Esther Lete   +2 more
openalex   +1 more source

Investigating operational stability and causes of cofactor release in fold type I amine transaminase

Protein Science, Volume 35, Issue 2, February 2026.
Abstract Amine transaminases (ATAs) are pyridoxal phosphate (PLP) dependent biocatalysts frequently employed in chiral amine synthesis. Yields of ATA‐catalyzed reactions often suffer from low enzyme operational stability due to weak interactions between the ATA and the aminated cofactor pyridoxamine phosphate (PMP), which can leak from the active site ...
Xuebin Feng, William Chau, Emma R. Master   +2 more
wiley   +1 more source

Harnessing Photoenzymatic Systems for Intermolecular C–H Fluorination

Angewandte Chemie, Volume 138, Issue 5, 28 January 2026.
Despite the remarkable versatility of enzymes for catalyzing complex organic transformations under mild aqueous conditions, no biocatalytic system has been reported for intermolecular C–H fluorination. A radical photoenzymatic approach is introduced that leverages a designed de novo protein scaffold with an unnatural amino acid to achieve precise ...
Yu Zhou, Danielle Lawson, Zihan Zhang, Yunling Deng, Hejun Deng, Connor J. O'Dea, Zachariah A. Page, Yi Lu   +7 more
wiley   +2 more sources

Key Residues for Controlling Enantioselectivity of Halohydrin Dehalogenase from Arthrobacter sp. Strain AD2, Revealed by Structure-Guided Directed Evolution

Applied and Environmental Microbiology, 2012
Lixia Tang, Xuechen Zhu, Huayu Zheng, R. Jiang, Maja Majerić Elenkov   +4 more
semanticscholar   +1 more source

Switching Enantioselectivity in Phenylalanine Ammonia Lyase for the Synthesis of Electron-Deficient Aromatic d-Amino Acids. [PDF]

Angew Chem Int Ed Engl
Buslov I, Desmons S, Wang W, Massaad LE, Hu X.   +4 more
europepmc   +1 more source

Combinatorial reshaping of the Candida antarctica lipase A substrate pocket for enantioselectivity using an extremely condensed library

Proceedings of the National Academy of Sciences of the United States of America, 2011
A. Sandström, Ylva Wikmark, Karin Engström, Jon Nyhlén, J. Bäckvall   +4 more
semanticscholar   +1 more source

Stereoselective Photoenzymatic Hydroarylation for the Construction of Quaternary Stereocenters. [PDF]

J Am Chem Soc
Raps FC, Jin CA, Brown AC, Sorigué D, Hyster TK.   +4 more
europepmc   +1 more source

Enantioselective alpha-Arylation of Benzamides via Synergistic Nickel and Metallaphotoredox Catalysis

, 2019
John A. Montgomery, Alexander W. Rand
openalex   +1 more source