Results 81 to 90 of about 149,811 (326)

Spatial Control Over Tether‐Tunable Coordination on Palladium for Divergent Synthesis of Bicyclo[n.1.0]alkanes via Oxidative Cyclopropanation of Enynes

Advanced Science, EarlyView.
We have developed a Pd‐catalyzed oxidative cyclopropanation of 1,n‐enynes employing cyclic diacyl peroxides as bifunctional reagents that serve as both tether‐tunable oxidants and spatially controlled dicarboxylate anions. ABSTRACT Bicyclo[n.1.0]alkanes are highly valuable scaffolds in drug discovery and synthetic chemistry.
Ting Yuan, Lei Shi
wiley   +1 more source

Enantiospecific Optical Sensing of Terpenes by an Aggregated Atropisomeric Platinum(II) Complex

Angewandte Chemie, EarlyView.
Aggregated metal complexes act as an artificial nose and permit reversible optical sensing of small volatile molecules like R/S‐limonene based on enantiospecific recognition. Abstract Terpenes are unfunctionalized small volatile organic compounds (VOCs) that are naturally abundant, relevant to climate change, and impose potential health risks.
Annika Huber, Alessandro Prescimone, Christof Sparr, Oliver S. Wenger   +3 more
wiley   +2 more sources

Machine learning-assisted amidase-catalytic enantioselectivity prediction and rational design of variants for improving enantioselectivity

Nature Communications
Biocatalysis is an attractive approach for the synthesis of chiral pharmaceuticals and fine chemicals, but assessing and/or improving the enantioselectivity of biocatalyst towards target substrates is often time and resource intensive.
Zi-Lin Li, Shuxin Pei, Ziying Chen, Teng-Yu Huang, Xu-Dong Wang, Lin Shen, Xuebo Chen, Qi-Qiang Wang, De-Xian Wang, Yu-Fei Ao   +9 more
doaj   +1 more source

Enantioselective cycloaddition reactions

ChemInform, 1991
Publisher Summary This chapter reviews the cycloadditions reactions because they are popular, widely used, and also constitutes enormous body of chemistry. The chapter focuses on the landmark achievements as well as state-of-the-art examples of relevant chemistry.
openaire   +2 more sources

Enantioselective Reductive Alkenylation of α‐CF2H (‐CF3) Amino Halides: Rapid Access to Chiral α‐CF2H (‐CF3) Allylamines

Advanced Science, EarlyView.
Difluoromethyl (CF2H) group, the bioisostere of hydroxyl thiol methyl or amide is privileged in medicinal chemistry due to hydrogen‐binding ability and lipophilic, metabolically stable, and chemical inert nature. However, enatioseleceive CF2H introduction remains challenging.
Peng Liu, Kuiliang Li, Yan He, Chen‐Hui Jiang, Ruo‐Xing Jin, Duo‐Duo Hu, Wei‐Cheng Zhao, Xuan Nie, Shang‐Zheng Sun, Xi‐Sheng Wang   +9 more
wiley   +1 more source

Engineering Fluoroacetate Dehalogenase by Growth‐Based Selections on Non‐Natural Organofluorides

Angewandte Chemie, EarlyView.
We present a high‐throughput selection system to engineer fluoroacetate dehalogenases (FAcDs). By challenging E. coli populations that produce diverse FAcD libraries to grow on non‐natural organofluorides as their sole carbon source, we isolated a panel of FAcD variants with improved activity and altered substrate specificity.
Suzanne C. Jansen, Pauline van Beers, Clemens Mayer   +2 more
wiley   +2 more sources

Copper-Catalyzed Enantioselective Oxysulfenylation of Alkenols: Synthesis of Arylthiomethyl-Substituted Cyclic Ethers [PDF]

, 2022
Ameya S. Burde, Sherry R. Chemler
openalex   +1 more source

Polymerase Chain Reaction. Perturbation Theory and Machine Learning Artificial Intelligence‐Experimental Microbiome Analysis: Applications to Ancient DNA and Tree Soil Metagenomics Cases of Study

Advanced Intelligent Systems, EarlyView.
The polymerase chain reaction (PCR).Perturbation Theory and Machine Learning framework integrates perturbation theory and machine learning to classify genetic sequences, distinguishing ancient DNA from modern controls and predicting tree health from soil metagenomic data.
Jose L. Rodriguez, Estefania Ascencio, Jose M. Ageitos, Lucia Feijoo, Shan He, Amirreza Daghighi, Gerardo M. Casanola‐Martin, Cristian R. Munteanu, Santiago Rodriguez Yañez, Alejandro Pazos, Harbil Bediaga, Brenda Durand Ordiales, Raquel Esteban, Ana‐Maria Heres, Jorge Curiel Yuste, Lur Epelde, Bakhtiyor Rasulev, Tomas Gonzalez, Sonia Arrasate, Humberto González‐Diaz   +19 more
wiley   +1 more source

Evaluation of the Impact of Flutriafol on Soil Culturable Microorganisms and on Soil Enzymes Activity

Agriculture
Fungicides play a role in managing plant diseases but raise concerns about environmental impact, emphasizing the need to understand and minimize their effects on non-target ecosystems. Flutriafol is a fungicide used to combat fungal diseases in crops. It
Diana-Larisa Roman, Mariana Adina Matica, Bianca-Vanesa Boros, Constantina-Bianca Vulpe, Adriana Isvoran   +4 more
doaj   +1 more source

Chiral Thioxanthones as Modulators of P-glycoprotein: Synthesis and Enantioselectivity Studies

Molecules, 2018
Recently, thioxanthone derivatives were found to protect cells against toxic P-glycoprotein (P-gp) substrates, acting as potent inducers/activators of this efflux pump.
Ana Lopes, Eva Martins, Renata Silva, Madalena M. M. Pinto, Fernando Remião, Emília Sousa, Carla Fernandes   +6 more
doaj   +1 more source