Results 11 to 20 of about 71,203 (273)
Animals, 2022 There is growing evidence that perturbation of the gut microbiome, known as “dysbiosis”, is associated with the pathogenesis of human and veterinary diseases that are not restricted to the gastrointestinal tract.
Aniello Schiano Moriello +2 more
doaj +1 more source
Cannabinoids, the endocannabinoid system, and pain: a review of preclinical studies.
Pain, 2021 This narrative review represents an output from the International Association for the Study of Pain's global task force on the use of cannabis, cannabinoids, and cannabis-based medicines (CBM) for pain management, informed by our companion systematic ...
D. Finn +5 more
semanticscholar +1 more source
Cell Death and Disease, 2023 Statins are the most prescribed lipid-lowering agents worldwide. Their use is generally safe, although muscular toxicity occurs in about 1 in 10.000 patients.
Hilal Kalkan +9 more
doaj +1 more source
Postsynaptic synucleins mediate endocannabinoid signaling
Nature Neuroscience, 2023 Endocannabinoids are among the most powerful modulators of synaptic transmission throughout the nervous system, and yet little is understood about the release of endocannabinoids from postsynaptic compartments.
E. Albarran +8 more
semanticscholar +1 more source
Endocannabinoid Overload [PDF]
Molecular Pharmacology, 2010 The signaling capacity of endogenous cannabinoids ("endocannabinoids") is tightly regulated by degradative enzymes. This Perspective highlights a research article in this issue (p. 996) in which the authors show that genetic disruption of monoacylglycerol lipase (MAGL), the principal degradative enzyme for the endocannabinoid 2-arachidonoylglycerol (2 ...
Aron H, Lichtman +2 more
openaire +2 more sources
Endocannabinoids and Reproduction [PDF]
International Journal of Endocrinology, 2014 Infertility is a worldwide reproductive health problem whose consequences have deep psychological and social impact in health, demographic change, and wellbeing. Thus, the knowledge of basic, conserved modulators of reproduction might contribute to the discovery of new potential target for the exploitation of drugs to treat infertility in humans ...
Rosaria Meccariello +3 more
openaire +4 more sources
Frontiers in Synaptic Neuroscience, 2021 Disinhibition of orexin-A/hypocretin-1 (OX-A) release occurs to several output areas of the lateral hypothalamus (LH) in the brain of leptin knockout obese ob/ob mice.
Lea Tunisi +12 more
doaj +1 more source
Review of the Endocannabinoid System.
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 2020 The endocannabinoid system (ECS) is a widespread neuromodulatory network involved in the developing central nervous system as well as playing a major role in tuning many cognitive and physiological processes.
Hui-Chen Lu, K. Mackie
semanticscholar +1 more source
Modulating the Neuromodulators: Dopamine, Serotonin, and the Endocannabinoid System.
Trends in Neurosciences, 2021 Dopamine (DA), serotonin (5-hydroxytryptamine, 5-HT), and endocannabinoids (ECs) are key neuromodulators involved in many aspects of motivated behavior, including reward processing, reinforcement learning, and behavioral flexibility.
K. Peters, J. Cheer, R. Tonini
semanticscholar +1 more source
Role of the Endocannabinoid System in the Regulation of Intestinal Homeostasis
Cellular and Molecular Gastroenterology and Hepatology, 2022 The maintenance of intestinal homeostasis is fundamentally important to health. Intestinal barrier function and immune regulation are key determinants of intestinal homeostasis and are therefore tightly regulated by a variety of signaling mechanisms. The
Hailey Cuddihey +2 more
semanticscholar +1 more source