Results 21 to 30 of about 71,203 (273)
Targeting gut dysbiosis against inflammation and impaired autophagy in Duchenne muscular dystrophy
EMBO Molecular Medicine, 2023 Nothing is known about the potential implication of gut microbiota in skeletal muscle disorders. Here, we provide evidence that fecal microbiota composition along with circulating levels of short‐chain fatty acids (SCFAs) and related metabolites are ...
Hilal Kalkan +14 more
doaj +1 more source
Cells, 2021 Peroxisome proliferator-activated receptors (PPARs) are a family of nuclear receptors including PPARα, PPARγ, and PPARβ/δ, acting as transcription factors to regulate the expression of a plethora of target genes involved in metabolism, immune reaction ...
F. Iannotti, R. Vitale
semanticscholar +1 more source
SEX DIFFERENCES AND THE ENDOCANNABINOID SYSTEM IN PAIN.
Pharmacology, Biochemistry and Behavior, 2021 Cannabis use has been increasing in recent years, particularly among women, and one of the most common uses of cannabis for medical purposes is pain relief.
H. Blanton +5 more
semanticscholar +1 more source
Endocannabinoid-Mediated Control of Neural Circuit Excitability and Epileptic Seizures
Frontiers in Neural Circuits, 2022 Research on endocannabinoid signaling has greatly advanced our understanding of how the excitability of neural circuits is controlled in health and disease.
Yuki Sugaya +3 more
doaj +1 more source
Nature Communications, 2020 Depression is the leading cause of disability worldwide. Recent observations have revealed an association between mood disorders and alterations of the intestinal microbiota.
G. Chevalier +15 more
semanticscholar +1 more source
Cells, 2020 Orexin-A (OX-A) protects the brain against oxidative stress-mediated ischemic injury. Since the endocannabinoid 2-arachidonoylglycerol (2-AG) and cannabinoid type-1 (CB1) receptors were previously shown to mediate some of the effects of OX-A exerted ...
Letizia Palomba +9 more
doaj +1 more source
Neuroprotective and Immunomodulatory Action of the Endocannabinoid System under Neuroinflammation
International Journal of Molecular Sciences, 2021 Endocannabinoids (eCBs) are lipid-based retrograde messengers with a relatively short half-life that are produced endogenously and, upon binding to the primary cannabinoid receptors CB1/2, mediate multiple mechanisms of intercellular communication within
L. Kasatkina, S. Rittchen, E. Sturm
semanticscholar +1 more source
Endocannabinoid Turnover [PDF]
, 2017 In this review, we consider the biosynthetic, hydrolytic, and oxidative metabolism of the endocannabinoids anandamide and 2-arachidonoylglycerol. We describe the enzymes associated with these events and their characterization. We identify the inhibitor profile for these enzymes and the status of therapeutic exploitation, which to date has been limited ...
Fowler, Christopher J. +2 more
openaire +5 more sources
The evolution and comparative neurobiology of endocannabinoid signalling [PDF]
, 2012 CB(1)- and CB(2)-type cannabinoid receptors mediate effects of the endocannabinoids 2-arachidonoylglycerol (2-AG) and anandamide in mammals. In canonical endocannabinoid-mediated synaptic plasticity, 2-AG is generated postsynaptically by diacylglycerol ...
Devane W. A. +4 more
core +1 more source
Endocannabinoid-related compounds in gastrointestinal diseases [PDF]
, 2018 The endocannabinoid system (ECS) is an endogenous signalling pathway involved in the control of several gastrointestinal (GI) functions at both peripheral and central levels.
Alessandra, D'Alessandro +7 more
core +1 more source