Results 81 to 90 of about 71,203 (273)

Sex‐dependent effects of endocannabinoid modulation of conditioned fear extinction in rats

British Journal of Pharmacology, 2020
Women are twice as likely as men to develop post‐traumatic stress disorder (PTSD) making the search for biological mechanisms underlying these gender disparities especially crucial.
M. Morena, Andrei S. Nastase, Alessia Santori, B. Cravatt, R. Shansky, Matthew N Hill   +5 more
semanticscholar   +1 more source

Mechanisms of spinal glial activation in chemotherapy‐induced peripheral neuropathy: Focus on microglia and astrocytes

Ibrain, EarlyView.
Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
wiley   +1 more source

Genetic and pharmacological regulation of the endocannabinoid CB1 receptor in Duchenne muscular dystrophy

Nature Communications, 2018
The regenerative capacity of muscle stem cells is impaired in Duchenne muscular dystrophy (DMD). Here, the authors show that the endocannabinoid receptor CB1 is activated by PAX7 in muscle stem cells, and that pharmacological inhibition of CB1 promotes ...
Fabio A. Iannotti, Ester Pagano, Ombretta Guardiola, Simone Adinolfi, Valentina Saccone, Silvia Consalvi, Fabiana Piscitelli, Elisabetta Gazzerro, Giuseppe Busetto, Diego Carrella, Raffaele Capasso, Pier Lorenzo Puri, Gabriella Minchiotti, Vincenzo Di Marzo   +13 more
doaj   +1 more source

Maintenance of aversive memories shown by fear extinction-impaired phenotypes is associated with increased activity in the amygdaloid-prefrontal circuit [PDF]

, 2016
Although aversive memory has been mainly addressed by analysing the changes occurring in average populations, the study of neuronal mechanisms of outliers allows understanding the involvement of individual differences in fear conditioning and extinction.
Caioli, Silvia, De Bartolo, Paola, LARICCHIUTA, DANIELA, PETROSINI, Laura, Saba, Luana, Zona, Cristina   +5 more
core   +1 more source

Potential application of endocannabinoid system agents in neuropsychiatric and neurodegenerative diseases—focusing on FAAH/MAGL inhibitors

Acta Pharmacologica Sinica, 2020
The endocannabinoid system (ECS) has received extensive attention for its neuroprotective effect on the brain. This system comprises endocannabinoids, endocannabinoid receptors, and the corresponding ligands and proteins.
Si-yu Ren, Zhen-Zhen Wang, Yi Zhang, N. Chen   +3 more
semanticscholar   +1 more source

Exploring the Role of Dysregulated Arousal in the Relationship Between Trauma and Addictive Behaviors Among College Students

Journal of Counseling &Development, EarlyView.
ABSTRACT The relationship between trauma and addictive behaviors is well‐established, yet factors mediating this relationship remain understudied. Given the prevalence of addictive behaviors among collegiate populations, we used path analysis to explore the mediating role of arousal dysregulation in the relationship between childhood trauma and a ...
Amanda L. Giordano, Kate M. Dorrough, Deborah L. Smith, Peitao Zhu   +3 more
wiley   +1 more source

Palmitoylethanolamide and Related ALIAmides: Prohomeostatic Lipid Compounds for Animal Health and Wellbeing

Veterinary Sciences, 2020
Virtually every cellular process is affected by diet and this represents the foundation of dietary management to a variety of small animal disorders. Special attention is currently being paid to a family of naturally occurring lipid amides acting through
Enrico Gugliandolo, Alessio Filippo Peritore, Cristian Piras, Salvatore Cuzzocrea, Rosalia Crupi   +4 more
doaj   +1 more source

Fibronectin modulates the endocannabinoid system through the cAMP/PKA pathway during human sperm capacitation [PDF]

, 2019
Fibronectin (Fn) enhances human sperm capacitation via the cAMP/PKA pathway, and the endocannabinoid system participates in this process. Moreover, Fn has been linked to endocannabinoid system components in different cellular models, even though no ...
Díaz, Emilce Silvina, Kong, Milene, Martínez León, Eduardo Antonio, Morales, Patricio, Osycka Salut, Claudia Elena, Perez Martinez, Silvina Laura, Signorelli, Janetti   +6 more
core   +1 more source

Endocannabinoid system in psychotic and mood disorders: A review of human studies.

Progress in Neuro-psychopharmacology and Biological Psychiatry, 2020
Despite widespread evidence of endocannabinoid system involvement in the pathophysiology of psychiatric disorders, our understanding remains rudimentary.
Ranjini Garani, Jeremy J. Watts, R. Mizrahi   +2 more
semanticscholar   +1 more source

Efficacy of omega‐3 fatty acids as a functional food: a multifaceted approach to health reinforcement

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Omega‐3 fatty acids (omega‐3s) are polyunsaturated fatty acids linked with numerous health benefits. Omega‐3s exhibit multifaceted activities through various mechanisms. Eicosapentaenoic acid (EPA) alleviates oxidative stress by lowering reactive oxygen species and improving oxidative stress in brain tissues and acts against neurodegenerative ...
Md Faruque Ahmad, Abdulrahman A Alsayegh, Anjum Khanam, Awais Ahmed, António Raposo, Farkad Bantun, Md Zeyaullah, Ahmad O Babalghith, Abdullah F Aldairi, Boshra Mozaffar, Mohammed F Bajahzer, Mohamed H Abdelrahman, Mohammad Intakhab Alam   +12 more
wiley   +1 more source