Interaction between Cannabinoid System and Toll-Like Receptors Controls Inflammation [PDF]
Mediators of Inflammation, 2016 Since the discovery of the endocannabinoid system consisting of cannabinoid receptors, endogenous ligands, and biosynthetic and metabolizing enzymes, interest has been renewed in investigating the promise of cannabinoids as therapeutic agents.
Kathleen L. McCoy
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Role of the Endocannabinoid System in Fibromyalgia [PDF]
Current Issues in Molecular BiologyFibromyalgia is a chronic disease marked by extensive musculoskeletal pain, persistent fatigue, and cognitive impairments. Despite its high prevalence, the underlying pathological mechanisms of fibromyalgia are still not fully elucidated.
Mario García-Domínguez
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From Fertilisation to Implantation in Mammalian Pregnancy—Modulation of Early Human Reproduction by the Endocannabinoid System [PDF]
Pharmaceuticals, 2010 There is an increasing recognition that the endocannabinoid system is the crucial cytokine-hormone system regulating early human pregnancy. The synchronous development of the fertilized embryo and the endometrium to ensure timely implantation has been ...
Justin C. Konje +7 more
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The endocannabinoid system and ophthalmic pathologies: a review of molecular mechanisms and its implications for clinical practice [PDF]
Frontiers in MedicineWithin the last decade the role of the endocannabinoid system (ECS) has been a significant part of ophthalmic research, including both ocular physiology and the development of eye pathologies.
Tomasz Charytoniuk +4 more
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Intrinsic up-regulation of 2-AG favors an area specific neuronal survival in different in vitro models of neuronal damage [PDF]
, 2012 BACKGROUND: The endocannabinoid 2-arachidonoyl glycerol (2-AG) acts as a retrograde messenger and modulates synaptic signaling e. g. in the hippocampus. 2-AG also exerts neuroprotective effects under pathological situations.
Bechmann, Ingo Jürgen +8 more
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The Microbiome and Gut Endocannabinoid System in the Regulation of Stress Responses and Metabolism
Frontiers in Cellular Neuroscience, 2022 The endocannabinoid system, with its receptors and ligands, is present in the gut epithelium and enteroendocrine cells, and is able to modulate brain functions, both indirectly through circulating gut-derived factors and directly through the vagus nerve,
Raj Kamal Srivastava +3 more
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Role of the Endocannabinoid System in the Adipose Tissue with Focus on Energy Metabolism
Cells, 2021 The endocannabinoid system is involved in a wide range of processes including the control of energy acquisition and expenditure. Endocannabinoids and their receptors are present in the central nervous system but also in peripheral tissues, notably the ...
Volatiana Rakotoarivelo +2 more
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The endocannabinoid system, cannabis, and cannabidiol: Implications in urology and men's health
Current Urology, 2021 . Background:. The endocannabinoid system is a neuromodulatory system responsible for partial regulation of cognitive and emotional processes in the human central nervous system such as behavior, mood disorders, and neurologic disorders such as epilepsy.
Jillian L. Capodice, Steven A. Kaplan
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Endocannabinoid system and periodontitis: mechanisms and therapeutic implications [PDF]
Revista de Odontologia da UNESP, 2023 Introduction Periodontitis is a major public health problem. Although the principle of periodontitis therapy is mainly focused on removing dental biofilm and associated factors, its physiopathology enrolls different molecular and inflammatory events ...
Lélio Fernando Ferreira SOARES +2 more
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Molecular components and functions of the endocannabinoid system in mouse prefrontal cortex. [PDF]
PLoS ONE, 2007 Cannabinoids have deleterious effects on prefrontal cortex (PFC)-mediated functions and multiple evidences link the endogenous cannabinoid (endocannabinoid) system, cannabis use and schizophrenia, a disease in which PFC functions are altered. Nonetheless,
Mathieu Lafourcade +5 more
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