The evolution and comparative neurobiology of endocannabinoid signalling [PDF]
, 2012 CB(1)- and CB(2)-type cannabinoid receptors mediate effects of the endocannabinoids 2-arachidonoylglycerol (2-AG) and anandamide in mammals. In canonical endocannabinoid-mediated synaptic plasticity, 2-AG is generated postsynaptically by diacylglycerol ...
Devane W. A. +4 more
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Endocannabinoid system: Potential novel targets for treatment of schizophrenia
Neurobiology of Disease, 2013 Accumulating epidemiological evidences suggest that cannabis use during adolescence is a potential environmental risk for the development of psychosis, including schizophrenia.
Atsushi Saito +4 more
doaj +1 more source
Biology of Sex Differences, 2021 Background Several chronic pain disorders, such as migraine and fibromyalgia, have an increased prevalence in the female population. The underlying mechanisms of this sex-biased prevalence have yet to be thoroughly documented, but could be related to ...
Aidan Levine +8 more
doaj +1 more source
Endocannabinoid-related compounds in gastrointestinal diseases [PDF]
, 2018 The endocannabinoid system (ECS) is an endogenous signalling pathway involved in the control of several gastrointestinal (GI) functions at both peripheral and central levels.
Alessandra, D'Alessandro +7 more
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Modulation of the Endocannabinoid System as a Potential Anticancer Strategy
Frontiers in Pharmacology, 2019 Currently, the involvement of the endocannabinoid system in cancer development and possible options for a cancer-regressive effect of cannabinoids are controversially discussed.
Robert Ramer +2 more
doaj +1 more source
Cannabinoid Receptor Involvement in Stress-Induced Cocaine Reinstatement: Potential Interaction with Noradrenergic Pathways [PDF]
, 2012 This study examined the role of endocannabinoid signaling in stress-induced reinstatement of cocaine seeking and explored the interaction between noradrenergic and endocannabinergic systems in the process.
Hillard, Cecilia J. +6 more
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Glucocorticoid-endocannabinoid interaction in cardiac surgical patients: relationship to early cognitive dysfunction and late depression [PDF]
, 2012 Background: Endocannabinoids (ECs) are rapidly acting immune-modulatory lipid-signaling molecules that are important for adaptation to stressful and aversive situations. They are known to interact with glucocorticoids and other stress-responsive systems.
Beiras-Fernandez, Andres +9 more
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Pitfalls in measuring the endocannabinoid 2-arachidonoyl glycerol in biological samples [PDF]
, 2007 Background: The endocannabinoid 2-arachidonoyl glycerol (2-AG) undergoes spontaneous isomerization to biologically inactive 1-AG. This effect has not been adequately addressed in previous studies that reported 2-AG concentrations in biological samples ...
Schelling, Gustav, Vogeser, Michael
core +1 more source
Gene expression of the endocannabinoid system in endometrium through menstrual cycle
Scientific Reports, 2022 Endocannabinoids mediate cellular functions and their activity is controlled by a complex system of enzymes, membrane receptors and transport molecules.
Keisuke Tanaka +8 more
doaj +1 more source
CB1 Receptor Antagonism Blocks Stress-Potentiated Reinstatement of Cocaine Seeking in Rats [PDF]
, 2015 Rationale Under some conditions, stress, rather than directly triggering cocaine seeking, potentiates reinstatement to other stimuli, including a subthreshold cocaine dose.
Baker, David A. +6 more
core +2 more sources