Results 81 to 90 of about 26,170 (225)

How copy number variations shape brain developmental disorders: Unraveling the synaptic puzzle

Psychiatry and Clinical Neurosciences, EarlyView.
Neurodevelopmental disorders (NDDs), such as schizophrenia (SCZ), Attention‐deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), learning disabilities, and intellectual disabilities (ID), are highly prevalent. One significant genetic factor associated with NDDs is copy number variations (CNVs), which are structural changes in the ...
Tianqi Wang, Kubra Trabzonlu, Emily Fullard Jones, Yasir Ahmed Syed   +3 more
wiley   +1 more source

Guessing at Ghosts in the Machine

Ratio, EarlyView.
ABSTRACT As AI grows ever more complex and ubiquitous, its moral status becomes increasingly pressing. But knowing whether an AI has moral status is only part of the ethical puzzle. To determine how we ought to treat such entities, we must know not only whether AIs have moral status, but also about the content of their interests—what contributes to ...
Helen Yetter‐Chappell
wiley   +1 more source

Role of cardiorespiratory fitness on the associations between endocannabinoid system and depressive symptoms in adults diagnosed with depression: the SONRIE study

, 2022
Manuel Ruiz Muñoz, Sonia Ortega‐Gómez, David Jiménez‐Pavón, Maria del Mar Espinosa-Nogales, Miguel Ángel Rosety, Vanesa España‐Romero   +5 more
openalex   +2 more sources

The effectiveness of aerobic exercise on pain and disability in individuals with neck pain: A systematic review and meta‐analysis

Experimental Physiology, EarlyView.
Abstract The present review aimed to investigate the effectiveness of aerobic exercise (AE) compared to other interventions in decreasing pain intensity and reducing disability in individuals with neck pain. A systematic review (SR) of randomized controlled trials was conducted. This SR was registered in PROSPERO (CRD42021231231).
Ana lzabela Sobral de Oliveira‐Souza, Marie Kempe, Sofia Grimmelsmann, Luiz Felipe Tavares, Ester Moreira De Castro‐Carletti, Angela Viegas Andrade, Liz Dennett, Harry Von Piekartz, Jorge Fuentes Contreras, Susan Armijo‐Olivo   +9 more
wiley   +1 more source

Cannabinoids: Well-Suited Candidates for the Treatment of Perinatal Brain Injury

Brain Sciences, 2013
Perinatal brain injury can be induced by a number of different damaging events occurring during or shortly after birth, including neonatal asphyxia, neonatal hypoxia-ischemia and stroke-induced focal ischemia.
José Martínez-Orgado, Maria Ángeles Moro, Ignacio Lizasoain, David Fernández-López   +3 more
doaj   +1 more source

Milk Fat Globule Membrane Supplementation Attenuates Cognitive Impairment in APP/PS1 Mice via Suppressing Neuroinflammation in a Gut Microbiota‐Mediated Serum Resolvin D1/Anandamide Manner

Food Frontiers, Volume 7, Issue 2, March 2026.
MFGM modulated gut microbiota accompanied by the increased serum RVD1 and AEA levels, which subsequently regulated the miRNA profile. This modulation alleviated neuroinflammation via suppressing the NLRP3 inflammasome signaling and microglial activation, thereby attenuating AD‐related cognitive impairment both in vivo and in vitro.
Han Gong, Qichen Yuan, Min Du, Xiaohan Liu, Xueying Mao   +4 more
wiley   +1 more source

Lactobacillus johnsonii Improves Intestinal Barrier Function and Reduces Post-Weaning Diarrhea in Piglets: Involvement of the Endocannabinoid System

Animals
Probiotic intervention is a well-established approach for replacing antibiotics in the management of weaning piglet diarrhea, which involves a large number of complex systems interacting with the gut microbiota, including the endocannabinoid system ...
Zhangzheng Yin, Kaijun Wang, Yun Liu, Yunxia Li, Fang He, Jie Yin, Wenjie Tang   +6 more
doaj   +1 more source

Adolescent exposure to THC in female rats disrupts developmental changes in the prefrontal cortex

Neurobiology of Disease, 2015
Current concepts suggest that exposure to THC during adolescence may act as a risk factor for the development of psychiatric disorders later in life. However, the molecular underpinnings of this vulnerability are still poorly understood. To analyze this,
Tiziana Rubino, Pamela Prini, Fabiana Piscitelli, Erica Zamberletti, Massimo Trusel, Miriam Melis, Claudia Sagheddu, Alessia Ligresti, Raffaella Tonini, Vincenzo Di Marzo, Daniela Parolaro   +10 more
doaj   +1 more source

Pan-phylum In Silico Analyses of Nematode Endocannabinoid Signalling Systems Highlight Novel Opportunities for Parasite Drug Target Discovery

, 2022
Bethany A. Crooks, Darrin Mckenzie, Luke C. Cadd, Ciaran J. McCoy, Paul McVeigh, Nikki J. Marks, Aaron G. Maule, Angela Mousley, Louise E. Atkinson   +8 more
openalex   +1 more source

Involvement of Adenosine A2A Receptors in Anxiety‐Like Behaviors in Tetrahydrocannabinol‐Treated Mice

Brain and Behavior, Volume 16, Issue 2, February 2026.
This study evaluated anxiety‐like behavior in mice across treatment and control groups using open field and elevated plus maze tests, followed by hippocampal receptor gene expression analysis. The combined behavioral and molecular data identify potential receptor‐level mechanisms underlying the observed treatment‐associated behavioral changes. ABSTRACT
Burçin Ün, Zeki Akarsakarya, Özlem Yorulmaz Özü, Nermin Seda Ilgaz, Mehmet Bertan Yılmaz, Deniz Seçilmiş, Mehmet Ata Seçilmiş   +6 more
wiley   +1 more source