Results 121 to 130 of about 18,120 (213)

Mechanical Regulation of Progenitor Cell Differentiation During Endochondral Ossification [PDF]

, 2019
Endochondral ossification is an indirect path of bone formation involving the condensation of progenitor cells into a cartilaginous anlage that grows in size, matures, and releases growth factors to promote blood vessel invasion and cartilage remodeling,
McDermott, Anna M.
core  

Engineering of a functional bone organ through endochondral ossification [PDF]

, 2013
Embryonic development, lengthening, and repair of most bones proceed by endochondral ossification, namely through formation of a cartilage intermediate.
Martin, I, Barbero, A, Scotti, C., Manz, M. G., Piccinini, E, Papadimitropoulos, A, Takizawa, H., Todorov, A., Barbero, A., Todorov, A, Takizawa, H, Bourgine, P., Scotti, C, Martin, I., Piccinini, E., Papadimitropoulos, A., Bourgine, P, Manz, M G   +17 more
core   +1 more source

Numerical and Experimental Assessment of Oxygen Distribution in a Perfusion Bioreactor to Mimic the Osteochondral Niche

Biotechnology and Bioengineering, Volume 123, Issue 8, Page 2139-2152, August 2026.
ABSTRACT Oxygen supply is a critical parameter in 3D cell cultivation using bioreactors. Since bioreactor designs often prioritise practical constraints, understanding the oxygen supply dynamics of the media is crucial for achieving either uniform or spatially controlled oxygen delivery.
Franziska Alt, Eric Langner, Hans‐Peter Wiesmann, Thomas Wallmersperger, Benjamin Kruppke   +4 more
wiley   +1 more source

Suspected multipartite patella in a Pomeranian dog successfully treated with osteochondral debridement, cerclage suture and transarticular external skeletal fixation

Veterinary Record Case Reports, Volume 14, Issue 3, August 2026.
Abstract A 4‐year‐old, male, neutered Pomeranian presented with a 3‐week history of an acute‐onset Grade 3/5 left pelvic limb lameness, with no reported history of trauma. Radiographic and computed tomographic studies revealed separation of the left patella into multiple small variably sized, minimally displaced, bony fragments, with rounded margins. A
Charlotte Nix, Robert Dudley
wiley   +1 more source

An unusual presentation of osteochondrosis in the elbows and tarsi of a Friesian colt

Equine Veterinary Education, Volume 38, Issue 8, Page e464-e471, August 2026.
Summary This case report describes the clinical, diagnostic imaging results and post‐mortem findings in a foal that underwent reassessment following surgical management of angular limb deformities (ALD) and acute onset of gait abnormalities. Upon presentation, the foal showed an abnormal stiff gait characterised by bilateral medial limb collapse during
A. Torrent‐Crosa, A. Merchán‐Muñoz, C. Co, E. Borkowski   +3 more
wiley   +1 more source

Repurposed Drugs for Heterotopic Ossification Management: Revitalizing Therapeutic Strategies

Pharmaceuticals
Background and Objectives: Heterotopic ossification (HO) involves abnormal bone growth in soft tissues. Current treatments are ineffective and prone to adverse effects, suggesting the need for new HO therapies.
Ana Alonso-Pérez, Eloi Franco-Trepat, María Guillán-Fresco, Miriam López-Fagúndez, Andrés Pazos-Pérez, Verónica López, Antonio Salas, Federico Martinón-Torres, Alberto A. Jorge-Mora, Rodolfo Gómez   +9 more
doaj   +1 more source

ECM signaling in cartilage development and endochondral ossification

, 2019
During cartilage development chondrocytes undergo a multi-step process characterized by consecutive changes in cell morphology and gene expression. Cell proliferation, polarity, differentiation, and migration are influenced by chemical and mechanical signaling between the extracellular matrix (ECM) and the cell.
Prein, Carina, Beier, Frank
openaire   +4 more sources

Donor-dependent regulation of type II and X collagen deposition by early modulation of miR-335-5p and miR-1246 during chondrogenic commitment

Stem Cell Research & Therapy
Background Identification of biomarkers to predict the risk of healing delays are of huge clinical interest since 10% of fracture patients progress to delayed or non-union.
Franziska L. Breulmann, Silvia A. Berger, Elena Della Bella, Martin J. Stoddart   +3 more
doaj   +1 more source

FGF7 as an essential mediator for the onset of ankylosing enthesitis related to psoriatic dermatitis

Life Science Alliance
This study sheds light on the pathogenic association between the skin and joints in psoriatic arthritis. The authors indicated that IL-17A, which is produced in the skin, induces joint manifestations via FGF7 signaling in the pathology of psoriatic ...
Shin Ebihara, Yuji Owada, Masao Ono
doaj   +1 more source

Endochondral ossification in Achilles and patella tendinopathy [PDF]

Rheumatology, 2002
S, Fenwick, R, Harrall, R, Hackney, S, Bord, A, Horner, B, Hazleman, G, Riley   +6 more
openaire   +2 more sources