Results 121 to 130 of about 18,079 (225)

Homozygous Achondroplasia With Long‐Term Survival: Growth Patterns, Medical Interventions, and Practice Implications

American Journal of Medical Genetics Part A, Volume 200, Issue 6, Page 1372-1377, June 2026.
ABSTRACT Homozygous achondroplasia is widely considered perinatal lethal by the medical community. In this case series, we report two children from a single family with longer‐term survival. One child lived for 17 months and the other was 60 months at the time of publication.
Hannah Singerline, Jason Laufman, Kimberly Wallis, Michelle Merrill   +3 more
wiley   +1 more source

Indomethacin induces differential effects on in vitro endochondral ossification depending on the chondrocyte's differentiation stage

, 2017
Heterotopic ossification (HO) is the abnormal formation of bone in soft tissues and is a frequent complication of hip replacement surgery. Heterotopic ossifications are described to develop via endochondral ossification and standard treatment is ...
Tim J. M. Welting, Caron, Marjolein M. J., Lodewijk W. van Rhijn, Welting, Tim J. M., Don A. M. Surtel, Marjolein M. J. Caron, Cremers, Andy, van Rhijn, Lodewijk W., Emans, Pieter J., Pieter J. Emans, Andy Cremers, Surtel, Don A. M.   +11 more
core   +1 more source

Repurposed Drugs for Heterotopic Ossification Management: Revitalizing Therapeutic Strategies

Pharmaceuticals
Background and Objectives: Heterotopic ossification (HO) involves abnormal bone growth in soft tissues. Current treatments are ineffective and prone to adverse effects, suggesting the need for new HO therapies.
Ana Alonso-Pérez, Eloi Franco-Trepat, María Guillán-Fresco, Miriam López-Fagúndez, Andrés Pazos-Pérez, Verónica López, Antonio Salas, Federico Martinón-Torres, Alberto A. Jorge-Mora, Rodolfo Gómez   +9 more
doaj   +1 more source

Unveiling a New Link: Cholesterol Deficiency in Smith–Lemli–Opitz and Niemann–Pick C as a Driver of Ciliopathies

American Journal of Medical Genetics Part A, Volume 200, Issue 6, Page 1179-1191, June 2026.
ABSTRACT The ciliopathies are a group of genetic disorders caused by defective function of either the primary cilia (a large number) or the motile cilia (a much smaller number). These have been defined as diseases with mutations in genes encoding individual ciliary or cilia‐associated proteins.
Robert P. Erickson, Maria Teresa Fiorenza   +1 more
wiley   +1 more source

New Insights Into Cranial Base Ontogeny in Modern Humans Through Morphometric Analysis

American Journal of Biological Anthropology, Volume 190, Issue 2, June 2026.
ABSTRACT Objectives The cranial base is located at the interface between the face, the brain, and the vertebral column. Understanding its growth is essential for elucidating key aspects of craniofacial development, neurodevelopment, and locomotor function.
Amaëlle Sourbé, Mathilde Savignat, Frédéric Santos, Thomas Colard   +3 more
wiley   +1 more source

Nanocrystalline Hydroxyapatite–Poly(thioketal urethane) Nanocomposites Stimulate a Combined Intramembranous and Endochondral Ossification Response in Rabbits

, 2019
Resorbable bone cements are replaced by bone through osteoclastic resorption and osteoblastic new bone formation near the periphery. However, the ideal bone cement would be replaced by new bone through processes similar to fracture repair, which occurs ...
Jeffry S. Nyman (8179527), Scott A. Guelcher (359831), Joseph C. Wenke (8179530), Cheyenne Rhodes (8179533), Dustin M. Groff (8179521), Jonathan G. Schoenecker (8179524), Dan Shimko (8179536), Madison A. P. McGough (8179515), Lauren A. Boller (8179518), Craig L. Duvall (1326867)   +9 more
core   +1 more source

Donor-dependent regulation of type II and X collagen deposition by early modulation of miR-335-5p and miR-1246 during chondrogenic commitment

Stem Cell Research & Therapy
Background Identification of biomarkers to predict the risk of healing delays are of huge clinical interest since 10% of fracture patients progress to delayed or non-union.
Franziska L. Breulmann, Silvia A. Berger, Elena Della Bella, Martin J. Stoddart   +3 more
doaj   +1 more source

ECM signaling in cartilage development and endochondral ossification

, 2019
During cartilage development chondrocytes undergo a multi-step process characterized by consecutive changes in cell morphology and gene expression. Cell proliferation, polarity, differentiation, and migration are influenced by chemical and mechanical signaling between the extracellular matrix (ECM) and the cell.
Prein, Carina, Beier, Frank
openaire   +4 more sources

Estimation and rapid identification of later stages during embryonic development of the oviparous lizard Sceloporus aeneus (Squamata: Phrynosomatidae)

The Anatomical Record, Volume 309, Issue 6, Page 1583-1598, June 2026.
Abstract Stages of embryonic development for reptiles have been presented in tables that may include all or part of embryonic development. When oviposition occurs in some lizards, embryos are already in the later stages of development; likewise, the size of the eggs increases as incubation time progresses.
Nivia Rocio Antonio‐Rubio, Maricela Villagrán‐SantaCruz, Martha Elena Díaz‐Hernández, Norma Moreno‐Mendoza   +3 more
wiley   +1 more source

FGF7 as an essential mediator for the onset of ankylosing enthesitis related to psoriatic dermatitis

Life Science Alliance
This study sheds light on the pathogenic association between the skin and joints in psoriatic arthritis. The authors indicated that IL-17A, which is produced in the skin, induces joint manifestations via FGF7 signaling in the pathology of psoriatic ...
Shin Ebihara, Yuji Owada, Masao Ono
doaj   +1 more source