Results 101 to 110 of about 18,120 (213)

Progress in bone tissue engineering biomaterials: Development, challenges, and prospects

VIEW, EarlyView.
Scheme 1 Application of biomaterials in immunomodulation during bone tissue engineering. Abstract Bone defect repair remains a major clinical challenge in orthopedics. Over 2 million cases caused by trauma, tumors, and other factors occur annually, with large‐scale defects posing a particular bottleneck due to limited self‐healing capacity.
Yuanbin Zhang, Junlei Chai, Quanwei Ding, Luping Liu, Kejie Zhang, Jie Lin, Jianhua Zhang, Youju Huang   +7 more
wiley   +1 more source

Soluble Epoxide Hydrolase Inhibition Regulates Septoclast Activity to Promote Long Bone Growth and Fracture Healing by Enhancing Endothelial‐to‐Mesenchymal Notch Signalling

Cell Proliferation, EarlyView.
The sEH inhibitor TPPU upregulates endothelial HIF‐1α, activating the NOTCH signalling pathway between endothelial cells and mesenchymal stem cells. This promotes the differentiation and formation of FABP5+ septoclasts, enhances their participation in endochondral ossification, and ultimately improves longitudinal bone growth and fracture healing ...
Weixian Chen, Liangliang Liu, Xumeng Wang, Juanjuan Li, Jingyi Zhang, Xiaoli Shi, Qing Sun, Xu Chang, Jing Zhang, Jie Zhao, Fu Wang   +10 more
wiley   +1 more source

Indomethacin induces differential effects on in vitro endochondral ossification depending on the chondrocyte's differentiation stage [PDF]

, 2017
Heterotopic ossification (HO) is the abnormal formation of bone in soft tissues and is a frequent complication of hip replacement surgery. Heterotopic ossifications are described to develop via endochondral ossification and standard treatment is ...
Tim J. M. Welting, Caron, Marjolein M. J., Lodewijk W. van Rhijn, Welting, Tim J. M., Don A. M. Surtel, Marjolein M. J. Caron, Cremers, Andy, van Rhijn, Lodewijk W., Emans, Pieter J., Pieter J. Emans, Andy Cremers, Surtel, Don A. M.   +11 more
core   +1 more source

ADAM17 and its proteolytic targets in disease pathogenesis

The FEBS Journal, EarlyView.
ADAM17 as a multifunctional sheddase with contrasting roles across inflammatory, metabolic, cardiovascular, and neoplastic diseases. Through regulated activation by iRhom, iTAP/FRMD8, and tetraspanins, ADAM17 cleaves diverse membrane ligands and receptors, thereby promoting inflammation, fibrosis, obesity, insulin resistance, and tumor progression ...
Abdulbasit Amin, Marina Badenes
wiley   +1 more source

Secondary cartilage in the murine medial pterygoid plate has a critical role in the pathfinding of the tensor veli palatini

Journal of Anatomy, EarlyView.
The development of the medial pterygoid plate (MPP) is followed in mouse embryos, highlighting its neural crest origin and complex development via both endochondral and membranous ossification. Using transgenic mice, the secondary cartilage of the MPP is shown to direct the path of the tensor veli palatini.
Luke A. Barlow, Emi Nomura, Abigail S. Tucker   +2 more
wiley   +1 more source

Nanocrystalline Hydroxyapatite–Poly(thioketal urethane) Nanocomposites Stimulate a Combined Intramembranous and Endochondral Ossification Response in Rabbits [PDF]

, 2019
Resorbable bone cements are replaced by bone through osteoclastic resorption and osteoblastic new bone formation near the periphery. However, the ideal bone cement would be replaced by new bone through processes similar to fracture repair, which occurs ...
Jeffry S. Nyman (8179527), Scott A. Guelcher (359831), Joseph C. Wenke (8179530), Cheyenne Rhodes (8179533), Dustin M. Groff (8179521), Jonathan G. Schoenecker (8179524), Dan Shimko (8179536), Madison A. P. McGough (8179515), Lauren A. Boller (8179518), Craig L. Duvall (1326867)   +9 more
core   +1 more source

How do forelimb long bones adapt in rhinoceroses? An in‐depth examination of their microanatomy

Journal of Anatomy, EarlyView.
Here, we study the bone structure in the forelimb long bones of the five extant species of rhinoceroses. By combining traditional description of virtual sections made on the bones (A) with in‐depth cartographies of the variation of bone compactness and anisotropy (B), we show how bone tissue can adapt to extreme forces and constraints in the second ...
Cyril Etienne, Axel de Jesus, Vincent Fernandez, Alexandra Houssaye   +3 more
wiley   +1 more source

Bone Grafts: Everything You Need to Know

Journal of Periodontal Research, EarlyView.
This review classifies bone grafts (autograft, allograft, xenograft, synthetic) by source and osteogenic/inductive/conductive potential, linking material properties and mechanisms to clinical indications in periodontal and dental regeneration. Key challenges—limited osteoinduction, poor vascularisation, unbalanced resorption, handling difficulties, and
Håvard Jostein Haugen, Javier Sanz, Giuseppe Perale, Augustine Mark Saiz, Mario Romandini, Maryam Rahmati   +5 more
wiley   +1 more source

Retained endochondral ossification of the distal ulnar growth plate in dogs [PDF]

, 2006
The aim of the study was an early diagnosis of bones with retained endochondral ossification through clinical and radiological examinations, in order to determine the factors causing the etiology of disease and to indicate necessary precautions to be ...
Guzel, O, Altunatmaz, Kemal, Saroglu, Murat   +2 more
core  

Modulating Endochondral Ossification of Multipotent Stromal Cells for Bone Regeneration [PDF]

, 2010
For years it has been recognized that engineering of large bone constructs will be feasible only if the hurdle of vascularization is overcome. Attempts to engineer bone tissue have predominantly focused on intramembranous (direct) bone formation.
Alblas, Jacqueline, Creemers, LB, Farrell, Eric, Dhert, WJA, Creemers, Laura, Wouter J.A. Dhert, Malda, Jos, Malda, J, Gawlitta, Debbie, Laura B. Creemers, Dhert, Wouter, Gawlitta, D, Alblas, J, Eric Farrell, Jacqueline Alblas, Debby Gawlitta, Jos Malda   +16 more
core   +1 more source