Bio-integrated scaffold facilitates large bone regeneration dominated by endochondral ossification. [PDF]
Sun L +9 more
europepmc +1 more source
Biomarkers for hypertrophic chondrocyte differentiation are associated with spatial cellular organisation and suggest endochondral ossification-like processes in osteoarthritic cartilage: An exploratory study. [PDF]
Wolfgart JM +7 more
europepmc +1 more source
Enhanced bone regeneration via endochondral ossification using Exendin-4-modified mesenchymal stem cells. [PDF]
He Z +10 more
europepmc +1 more source
THE FATE OF CHONDROCYTES IN ENDOCHONDRAL OSSIFICATION IN THE RABBIT
1. The epiphyses of the metatarsal heads of 250-gramme rabbits were separated at the zone of cell columns, stripped of perichondrium, labelled with tritiated thymidine and transplanted into the back muscles of the same animals. 2. Endochondral ossification started in the grafts at four days, was well established by seven days and progressed until ...
G, Bentley, R B, Greer
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Endochondral ossification takes place with calcified cartilage cores providing a rigid scaffold for new bone formation. Intramembranous ossification begins in connective tissue and new bone formed by a process of static ossification (SO) followed by ...
Marzia Ferretti +2 more
exaly +2 more sources
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Endochondral Ossification in Achondroplastic Dwarfism
New England Journal of Medicine, 1970Abstract The literature concerning endochondral histopathology in the chondrodystrophies is misleading because the true heterogeneity of this group of disorders was not recognized until relatively ...
D L, Rimoin +5 more
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Endostatin inhibits endochondral ossification
The Journal of Gene Medicine, 2007AbstractBackgroundAngiogenesis is essential for the replacement of cartilage by bone during skeletal growth and regeneration. Vascular endothelial growth factor‐A (VEGF‐A) is a key regulator of angiogenesis whereas endostatin, a potent inhibitor of endothelial cell proliferation and migration, is a natural antagonist of VEGF‐A.
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The role of morphogens in endochondral ossification
Calcified Tissue International, 1992The formation of bone occurs normally by one of two developmental processes: intramembranous or endochondral ossification. Endochondral ossification occurs in the morphogenesis of the limb buds and growth plates, and in the regeneration of bone following injury (fracture callus).
J T, Campbell, F S, Kaplan
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Focal Failures of Endochondral Ossification in the Broiler
Avian Diseases, 1982Two types of cartilaginous lesions were observed in a flock of 400 broilers separated into four groups and fed diets containing different energy and NH4Cl contents. The lesions appeared morphologically, histologically, and etiologically different.
P C, McCaskey +3 more
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Mechanical stresses and endochondral ossification in the chondroepiphysis
Journal of Orthopaedic Research, 1988AbstractIn 1911, Gebhardt used a photoelastic model to relate mechanical stresses to the ossification pattern of the chondroepiphysis. Pauwels later conducted a photoelastic study using the same model geometry to develop a theory that the secondary ossific nucleus originates at a position of high‐magnitude hydrostatic pressure where the shear stresses ...
D R, Carter, M, Wong
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