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Focal Failures of Endochondral Ossification in the Broiler
Avian Diseases, 1982Two types of cartilaginous lesions were observed in a flock of 400 broilers separated into four groups and fed diets containing different energy and NH4Cl contents. The lesions appeared morphologically, histologically, and etiologically different.
P C, McCaskey +3 more
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Endochondral ossification and the evolution of limb proportions
WIREs Developmental Biology, 2020AbstractMammals have remarkably diverse limb proportions hypothesized to have evolved adaptively in the context of locomotion and other behaviors. Mechanistically, evolutionary diversity in limb proportions is the result of differential limb bone growth.
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Defective endochondral ossification in brachymorphic mice
Journal of Comparative Pathology, 1977Abstract In mice of a brachymorphic strain, endochondral ossification was characterized by the absence of hypertrophy and by disorientation of the cartilage closest to the metaphysis. The change is considered to be qualitative, and the abnormality in these mice should thus not be classified as achondroplasia.
R, Silberberg, P, Lesker
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Process Heterochronies in Endochondral Ossification
Journal of Theoretical Biology, 2000Heterochrony, evolutionary changes in developmental rates and timing, is a key concept in the construction of a synthesis of development and evolution. Heterochronic changes in vertebrate evolution have traditionally been identified through plesiomorphic-apomorphic comparisons of bone growth.
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Effect of therapeutic ultrasound on endochondral ossification
Ultrasound in Medicine & Biology, 1995The effect of therapeutic doses of ultrasound was tested on endochondral ossification of in vitro developing metatarsal long bone rudiments of 16- and 17-day-old fetal mice. Bone growth, calcification and resorption following exposure to several doses of pulse-wave (PW) or continuous-wave (CW) ultrasound were examined.
Wiltink, A. +4 more
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The emergence of mechanoregulated endochondral ossification in evolution
Journal of Biomechanics, 2013The differentiation of skeletal tissue phenotypes is partly regulated by mechanical forces. This mechanoregulatory aspect of tissue differentiation has been the subject of many experimental and computational investigations. However, little is known about what factors promoted the emergence of mechanoregulated tissue differentiation in evolution, even ...
Hanifeh, Khayyeri +1 more
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Role of proteoglycans in endochondral ossification: Inhibition of calcification
Calcified Tissue International, 1985Proteoglycans from bovine nasal septa and from the Swarm rat chondrosarcoma were isolated as aggregates (PGC) and as monomers (PGS). Portions of the PGC preparations were degraded with cathepsin D or chondroitinase AC. Chondroitin sulfates were isolated by differential precipitation from alkaline digests of the PGS from bovine nasal septa.
D D, Dziewiatkowski, L L, Majznerski
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Origin and development of septoclasts in endochondral ossification of mice
Histochemistry and Cell Biology, 2018Septoclasts are mononuclear spindle-shaped phagocytes with their long processes in uncalcified cartilage matrices and locate adjacent to the capillary endothelium at the chondro-osseous junction of the growth plate. We have previously revealed a selective expression of epidermal-type fatty acid-binding protein (E-FABP/FABP5) in septoclasts.
Yasuhiko, Bando +7 more
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Inhibitory effect of bFGF on endochondral heterotopic ossification
Biochemical and Biophysical Research Communications, 2002Basic fibroblast growth factor (bFGF) is reported to stimulate repair of fracture and bony defects in in vivo animal studies. However, most studies performed in vitro demonstrate inhibitory effect of bFGF on cartilage and bone differentiation. To understand the discrepancy observed in in vivo and in vitro studies, we evaluated the effect of bFGF on ...
Shinji, Sakano +7 more
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Evolutionary origin of endochondral ossification: the transdifferentiation hypothesis
Development Genes and Evolution, 2016The vertebrate endoskeleton results from the piecemeal assembly of bone and cartilage as well as additional types of calcified extracellular matrices produced by seemingly hybrid cell types of intermediate phenotypes between osteoblasts and chondrocytes.
Fret Cervantes-Diaz +2 more
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