Results 1 to 10 of about 45,559 (245)
Epithelial cell plasticity drives endoderm formation during gastrulation
Nature Cell Biology, 2021 It is generally accepted that epiblast cells ingress into the primitive streak by epithelial-to-mesenchymal transition (EMT) to give rise to the mesoderm; however, it is less clear how the endoderm acquires an epithelial fate.
Ingo Burtscher +2 more
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Nature Communications, 2020 Visceral organs, such as the lungs, stomach and liver, are derived from the fetal foregut through a series of inductive interactions between the definitive endoderm (DE) and the surrounding splanchnic mesoderm (SM).
Lu Han +2 more
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GATA6 is essential for endoderm formation from human pluripotent stem cells
Biology Open, 2017 Protocols have been established that direct differentiation of human pluripotent stem cells into a variety of cell types, including the endoderm and its derivatives. This model of differentiation has been useful for investigating the molecular mechanisms
J. B. Fisher +3 more
doaj +2 more sources
Nature Genetics, 2019 Human embryonic stem cells (ESCs) and human induced pluripotent stem cells hold great promise for cell-based therapies and drug discovery. However, homogeneous differentiation remains a major challenge, highlighting the need for understanding ...
Qing V Li, Gary Dixon, Nipun Verma
exaly +2 more sources
The lncRNA DEANR1 Facilitates Human Endoderm Differentiation by Activating FOXA2 Expression
Cell Reports, 2015 Long non-coding RNAs (lncRNAs) regulate diverse biological processes, including cell lineage specification. Here, we report transcriptome profiling of human endoderm and pancreatic cell lineages using purified cell populations.
Wei Jiang +4 more
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Cell Reports, 2016 Long noncoding RNAs (lncRNAs) exhibit diverse functions, including regulation of development. Here, we combine genome-wide mapping of SMAD3 occupancy with expression analysis to identify lncRNAs induced by activin signaling during endoderm ...
Kaveh Daneshvar +13 more
doaj +2 more sources
The emergent landscape of the mouse gut endoderm at single-cell resolution
Nature, 2019 Sonja Nowotschin +2 more
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Science, 2022 The mammalian blastocyst consists of three distinct cell types: epiblast, trophoblast (TB), and primitive endoderm (PrE). Although embryonic stem cells (ESCs) and trophoblast stem cells (TSCs) retain the functional properties of epiblast and TB ...
Y. Ohinata +11 more
semanticscholar +1 more source
Cells, 2021 The endoderm, differentiated from human induced pluripotent stem cells (iPSCs), can differentiate into the small intestine and liver, which are vital for drug absorption and metabolism.
Shimeng Qiu +6 more
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A novel method for generating induced pluripotent stem cell (iPSC)-derived alveolar organoids: a comparison of their ability depending on iPSC origin [PDF]
Organoid, 2023 Background Alveolar organoids may be useful tools in drug discovery for lung diseases, such as chronic obstructive pulmonary disease, and for studying the effects of respiratory viruses, such as severe acute respiratory syndrome coronavirus 2.
Min Jae Lim, Ayoung Jo, Sung-Won Kim
doaj +1 more source