Results 31 to 40 of about 45,559 (245)
Vertebrate intestinal endoderm development [PDF]
Developmental Dynamics, 2011 AbstractThe endoderm gives rise to the lining of the esophagus, stomach and intestines, as well as associated organs. To generate a functional intestine, a series of highly orchestrated developmental processes must occur. In this review, we attempt to cover major events during intestinal development from gastrulation to birth, including endoderm ...
Jason R, Spence +2 more
openaire +2 more sources
Genome Biology, 2016 Human pluripotent stem cells offer the best available model to study the underlying cellular and molecular mechanisms of human embryonic lineage specification.
Li-Fang Chu +9 more
semanticscholar +1 more source
PI3K/Akt1 signalling specifies foregut precursors by generating regionalized extra-cellular matrix
eLife, 2013 During embryonic development signalling pathways act repeatedly in different contexts to pattern the emerging germ layers. Understanding how these different responses are regulated is a central question for developmental biology.
S Nahuel Villegas +7 more
doaj +1 more source
The endoderm: a divergent cell lineage with many commonalities
Development, 2019 The endoderm is a progenitor tissue that, in humans, gives rise to the majority of internal organs. Over the past few decades, genetic studies have identified many of the upstream signals specifying endoderm identity in different model systems, revealing
Sonja Nowotschin +2 more
semanticscholar +1 more source
Developmental Cell, 2019 Summary Epithelial tissues typically form lumina. In mammalian blastocysts, in which the first embryonic lumen forms, many studies have investigated how the cell lineages are specified through genetics and signaling, whereas potential roles of the fluid ...
A. Ryan +3 more
semanticscholar +1 more source
Visceral endoderm expression of Yin-Yang1 (YY1) is required for VEGFA maintenance and yolk sac development. [PDF]
PLoS ONE, 2013 Mouse embryos lacking the polycomb group gene member Yin-Yang1 (YY1) die during the peri-implantation stage. To assess the post-gastrulation role of YY1, a conditional knock-out (cKO) strategy was used to delete YY1 from the visceral endoderm of the yolk
Siyeon Rhee +5 more
doaj +1 more source
Vg1-Nodal heterodimers are the endogenous inducers of mesendoderm
eLife, 2017 Nodal is considered the key inducer of mesendoderm in vertebrate embryos and embryonic stem cells. Other TGF-beta-related signals, such as Vg1/Dvr1/Gdf3, have also been implicated in this process but their roles have been unclear or controversial.
Tessa G Montague, Alexander F Schier
doaj +1 more source
Cell Reports, 2020 Summary: Immune cells in the mucosal barriers of vertebrates are highly heterogeneous in their origin and function. This heterogeneity is further exemplified by the recent discovery of ectoderm-derived immune cells—metaphocytes in zebrafish epidermis ...
Xi Lin +4 more
doaj +1 more source
Genome Biology, 2023 Background Extensive studies have revealed the function and mechanism of lncRNAs in development and differentiation, but the majority have focused on those lncRNAs adjacent to protein-coding genes.
Pei Lu +9 more
doaj +1 more source
Retinoic acid signaling organizes endodermal organ specification along the entire antero-posterior axis. [PDF]
PLoS ONE, 2009 BACKGROUND: Endoderm organ primordia become specified between gastrulation and gut tube folding in Amniotes. Although the requirement for RA signaling for the development of a few individual endoderm organs has been established a systematic assessment of
Elke Bayha +3 more
doaj +1 more source