Results 71 to 80 of about 45,559 (245)

BMP signaling induces visceral endoderm differentiation of XEN cells and parietal endoderm [PDF]

Developmental Biology, 2012
The extraembryonic endoderm of mammals is essential for nutritive support of the fetus and patterning of the early embryo. Visceral and parietal endoderm are major subtypes of this lineage with the former exhibiting most, if not all, of the embryonic patterning properties.
Paca, Agnieszka, Séguin, Cheryle A., Clements, Melanie, Ryczko, Michael, Rossant, Janet, Rodriguez, Tristan A., Kunath, Tilo   +6 more
openaire   +3 more sources

Establishment of Interspecies Somatic Cell Nuclear Transfer and Transgene‐Free Inducible Pluripotent Stem Cells for Versatile Conservation of the Germplasm Resource of Wild Boar

Animal Research and One Health, EarlyView.
Conserving genetic material and even increasing genetic diversity is critical. To conduct the conservation of wild boar germplasm resources, we have successfully obtained healthy cloned wild boars for the first time using interspecies somatic cell nuclear transfer and established transgene‐free iPSCs that can be used to conduct iterative rounds of gene
Chen Gao, Xinyi Zhou, Shigang Gu, Jianbo Li, Jing Wang, Yurong Zhang, Wenxuan Zhao, Xinhua Wei, Liting Lu, Quanmin Zhao, Yongye Huang, Dawei Yu   +11 more
wiley   +1 more source

Induced Pluripotent Stem Cells as a Tool to Decipher the Normal and Abnormal Development of the Esophagus and Trachea from Normal Morphogenesis to Esophageal Atresia, Tracheomalacia, and Laryngo–Tracheal Clefts

Cells
The development of the esophagus and trachea following the septation of the anterior foregut is a highly regulated process involving bidirectional communication between the endoderm and mesoderm.
Yuxuan Zhang, Anu David, Alireza Nemati, Christophe Faure   +3 more
doaj   +1 more source

Effect of Hepatic Differentiation on Fatty Acid Composition of Induced Pluripotent Stem Cells Derived from Human Dermal Fibroblasts

İstanbul Medical Journal, 2018
Introduction: Human induced pluripotent stem cells (hiPSCs) have been recognized as key progenitor cells for liver regeneration, which could potentially be used in the repair of liver injury.
Nasim Parsafam, Yagoub Rahimi, Amir Mehdizadeh, Hojjatollah Nozad Charoudeh, Mohammad Nouri, Maghsod Shaaker, Masoud Darabi   +6 more
doaj   +1 more source

Differential sensitivity of midline development to mitosis during and after primitive streak extension

Developmental Dynamics, EarlyView.
Abstract Background Midline establishment is a fundamental process during early embryogenesis for Bilaterians. Midline morphogenesis in non‐amniotes can occur without mitosis, through Planar Cell Polarity (PCP) signaling. By contrast, amniotes utilize both cellular processes for developing the early midline landmark, the primitive streak (PS).
Zhiling Zhao, Rieko Asai, Takashi Mikawa
wiley   +1 more source

Spatiotemporal cellular dynamics of the notochord shape intervertebral disc morphogenesis in the mouse embryo through apoptosis and proliferation

Developmental Dynamics, EarlyView.
Abstract Background The notochord is a midline structure essential for vertebrate embryogenesis, contributing to the development of the nervous system, digestive tract, and vertebral column. In particular, notochord signaling is indispensable for proper patterning and coordinated development of alternating vertebrae and intervertebral discs (IVDs ...
Julie Warin, Estelle Balissat, Pauline Colombier, Lily Paillat, Maeva Dutilleul, Anne Camus   +5 more
wiley   +1 more source

Formation of a polarised primitive endoderm layer in embryoid bodies requires fgfr/erk signalling.

PLoS ONE, 2014
The primitive endoderm arises from the inner cell mass during mammalian pre-implantation development. It faces the blastocoel cavity and later gives rise to the extraembryonic parietal and visceral endoderm.
Gail Doughton, Jun Wei, Nicolas Tapon, Melanie J Welham, Andrew D Chalmers   +4 more
doaj   +1 more source

Micro Pattern‐Based 3D Cell Culture Platform: An Overview of Technologies and Applications

Exploration, EarlyView.
Micro patterns are characterized as a coating of specific adhesion matrices on substrates to support cell growth. An overview of micropattern technology to regulate single cell morphology and fates, further focusing on the micro pattern‐based 3D cell culture platform used in the non‐tumor and tumor researches.
Xinglong Zhu, Yi Li, Hulin Long, Yijia Wu, Ningwei Sun, Shun Li, Yiyao Liu, Huiqi Xie, Ji Bao   +8 more
wiley   +1 more source

Microengineering the Liver: Strategies for Constructing Functional Liver‐on‐a‐Chip Devices

Exploration, EarlyView.
This review summarizes recent advances in liver‐on‐a‐chip (LOC) technologies, including fabrication strategies and functional integration approaches, and discusses their promising applications in drug screening and related biomedical fields. ABSTRACT Reliable in vitro liver models are indispensable for researching liver diseases and developing ...
Jie Wang, Ziwei Liang, Jiapu Wang, Zongyi Li, Shaojie Wang, Yan Wei, Xin Xie, Di Huang   +7 more
wiley   +1 more source

NF2 is Essential for Human Endoderm Development

Advanced Science
Vertebrate embryogenesis requires the precisely timed specification of 3 germ cell layers— ectoderm, mesoderm, and endoderm— which give rise to tissues and organs in the developing organism.
Minjin Jeong, Dongjun Han, Preetida Bhetariya, D. Bradley Welling, Miodrag Stojkovic, Konstantina M. Stankovic   +5 more
doaj   +1 more source