Results 21 to 30 of about 32,233 (214)

Computational investigation of conformational variability and allostery in cathepsin K and other related peptidases.

PLoS ONE, 2017
Allosteric targeting is progressively gaining ground as a strategy in drug design. Its success, however, depends on our knowledge of the investigated system.
Marko Novinec
doaj   +1 more source

Insights into the mechanism of cyanobacteria removal by the algicidal fungi Bjerkandera adusta and Trametes versicolor

MicrobiologyOpen, 2020
Fungal mycelia can eliminate almost all cocultured cyanobacterial cells within a short time. However, molecular mechanisms of algicidal fungi are poorly understood.
Guomin Han, Hui Ma, Shenrong Ren, Xueyan Gao, Xiaolong He, Suwen Zhu, Ruining Deng, Shihua Zhang   +7 more
doaj   +1 more source

Endopeptidase 24.16B. A new variant of endopeptidase 24.16.

The Journal of biological chemistry, 1995
A peptidase, isolated from rat testes, is inhibited by 1 mM o-phenanthroline, 1 microM N-(1-(R,S)-carboxyl-3-phenylpropyl)-Ala-Ala-Phe-p-aminobenzoate, and 6 mM Pro-Ile, properties similar to those ascribed to endopeptidase 24.16. The enzyme hydrolyzes dynorphin A-8, neurotensin 1-13, angiotensin I, and substance P.
D, Rodd, L B, Hersh
openaire   +2 more sources

Amyloid beta and Alzheimer’s Disease: The role of neprilysin-2 in amyloid-beta clearance

Frontiers in Aging Neuroscience, 2014
Accumulation of the amyloid-beta (Ab) peptide is a central factor in Alzheimer’s disease (AD) pathogenesis as supported by continuing evidence. This review concisely summarizes this evidence supporting a critical role for Ab in AD before discussing the ...
Robert eMarr, Daniel eHafez
doaj   +1 more source

Genetic Evidence for Distinct Functions of Peptidoglycan Endopeptidases in Escherichia coli

Frontiers in Microbiology, 2020
Peptidoglycan (PG) is an essential component of the bacterial exoskeleton that plays a pivotal role in the maintenance of cell shape and resistance to cell lysis under high turgor pressures.
Si Hyoung Park, Yung Jae Kim, Han Byeol Lee, Yeong-Jae Seok, Chang-Ro Lee   +4 more
doaj   +1 more source

Influence of heavy metals on biosynthesis, activity of lytic enzymes and growthstimulating factor of Streptomyces recifensis var. lyticus P-29

Vìsnik Dnìpropetrovsʹkogo Unìversitetu: Serìâ Bìologìâ, Ekologìâ, 2005
Influence of heavy metals on growth, biosynthesis, lytic action and growthstimulating activity enzymes complex of Streptomyces recifensis var. lyticus was studied.
Т. P. Kilochok, I. E. Sokolova, N. P. Chernogor, А. А. Tymchuk, I. V. Zhernosekova   +4 more
doaj   +1 more source

Antioxidant potential and physicochemical properties of protein hydrolysates from body parts of North Atlantic sea cucumber (Cucumaria frondosa)

Food Production, Processing and Nutrition, 2021
Protein hydrolysates were prepared from North Atlantic sea cucumber (Cucumaria frondosa) body wall (BW), and processing by-product flower (FL) and internal organs (IN).
Tharindu R. L. Senadheera, Deepika Dave, Fereidoon Shahidi   +2 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Advancing botulism diagnostics: integrating molecularly specific in vitro platforms and high-sensitivity analytical technologies as alternatives to the mouse bioassay

Zaporožskij Medicinskij Žurnal
Accurate detection of botulinum neurotoxin (BoNT) requires assessing both its proteolytic SNARE-cleaving activity and its ability to inhibit synaptic transmission.
Ya. D. Bondarenko , O. V. Kochnieva
doaj   +1 more source

Molecular basis for the production of cyclic peptides by plant asparaginyl endopeptidases

Nature Communications, 2018
Asparaginyl endopeptidases (AEPs) are plant proteases that can also function as ligases, catalyzing the production of cyclic plant peptides. Here, the authors identify structural features that govern AEP ligase activity, providing insights to aid the ...
M. A. Jackson, E. K. Gilding, T. Shafee, K. S. Harris, Q. Kaas, S. Poon, K. Yap, H. Jia, R. Guarino, L. Y. Chan, T. Durek, M. A. Anderson, D. J. Craik   +12 more
doaj   +1 more source