Results 31 to 40 of about 35,058 (249)
Amyloid beta and Alzheimer’s Disease: The role of neprilysin-2 in amyloid-beta clearance
Frontiers in Aging Neuroscience, 2014 Accumulation of the amyloid-beta (Ab) peptide is a central factor in Alzheimer’s disease (AD) pathogenesis as supported by continuing evidence. This review concisely summarizes this evidence supporting a critical role for Ab in AD before discussing the ...
Robert eMarr, Daniel eHafez
doaj +1 more source
Site‐Specific Protein Bioconjugation Through Cellular Incorporation of Noncanonical Amino Acids
Angewandte Chemie, EarlyView.Genetic code expansion (GCE) enables site‐specific installation of noncanonical amino acids containing bioorthogonal conjugation handles, allowing precise, homogeneous protein modification. This review examines the principles of orthogonal translation, surveys the chemistries available for chemoselective labeling, and highlights emerging multi‐site ...
Rahul Sarkar +2 more
wiley +2 more sources
Genetic Evidence for Distinct Functions of Peptidoglycan Endopeptidases in Escherichia coli
Frontiers in Microbiology, 2020 Peptidoglycan (PG) is an essential component of the bacterial exoskeleton that plays a pivotal role in the maintenance of cell shape and resistance to cell lysis under high turgor pressures.
Si Hyoung Park +4 more
doaj +1 more source
An IscS Persulfide Donates the Sulfur for Ribosomal Protein uL16 Thioamidation
Angewandte Chemie, EarlyView.YcaO‐catalyzed thioamidation of the ribosomal subunit protein uL16 is widespread in Pseudomonadota bacteria. We identify the iron–sulfur cluster cysteine desulfurase IscS as the sulfur donor via an IscS persulfide and observe direct IscS–uL16 interactions.
Yanqing Xue +2 more
wiley +2 more sources
Vìsnik Dnìpropetrovsʹkogo Unìversitetu: Serìâ Bìologìâ, Ekologìâ, 2005 Influence of heavy metals on growth, biosynthesis, lytic action and growthstimulating activity enzymes complex of Streptomyces recifensis var. lyticus was studied.
Т. P. Kilochok +4 more
doaj +1 more source
Endopeptidase 24.16B. A new variant of endopeptidase 24.16.
The Journal of biological chemistry, 1995 A peptidase, isolated from rat testes, is inhibited by 1 mM o-phenanthroline, 1 microM N-(1-(R,S)-carboxyl-3-phenylpropyl)-Ala-Ala-Phe-p-aminobenzoate, and 6 mM Pro-Ile, properties similar to those ascribed to endopeptidase 24.16. The enzyme hydrolyzes dynorphin A-8, neurotensin 1-13, angiotensin I, and substance P.
D, Rodd, L B, Hersh
openaire +2 more sources
Structure and Function of a Multi‐Megadalton Virus‐Like Proteolytic Dodecahedron
Angewandte Chemie, EarlyView.Zuzalysin, a virulence metallopeptidase of the periodontal pathogen Porphyromonas gingivalis, is secreted as a latent, flexible ≈95‐kDa monomer. Calcium triggers cysteine‐switch activation and hierarchical assembly into pentamers, bipentamers, tripentamers, and a ≈5.6‐MDa, ≈355‐Å dodecahedron. Structures at 1.8–3.6 Å reveal a virus‐sized catalytic cage
Mariusz Madej +20 more
wiley +2 more sources
Food Production, Processing and Nutrition, 2021 Protein hydrolysates were prepared from North Atlantic sea cucumber (Cucumaria frondosa) body wall (BW), and processing by-product flower (FL) and internal organs (IN).
Tharindu R. L. Senadheera +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Fertilized egg cells secrete endopeptidases to avoid polytubey
, 2021 Upon gamete fusion, animal egg cells secrete proteases from cortical granules to establish a fertilization envelope as a block to polyspermy(1-4). Fertilization in flowering plants is more complex and involves the delivery of two non-motile sperm cells ...
Peng, Xiongbo +19 more
core +1 more source