Results 31 to 40 of about 62,083 (343)

Plant Viral Proteases: Beyond the Role of Peptide Cutters

Frontiers in Plant Science, 2018
Almost half of known plant viral species rely on proteolytic cleavages as key co- and post-translational modifications throughout their infection cycle. Most of these viruses encode their own endopeptidases, proteases with high substrate specificity that
Bernardo Rodamilans, Hongying Shan, Fabio Pasin, Juan Antonio García   +3 more
doaj   +1 more source

Downregulation of MMP-2 and MMP-9 genes in obesity patients and their relation with obesity-related phenotypes

Türk Biyokimya Dergisi, 2022
Adipose tissue mediates various bioactive molecules and cytokine discharge. The anti-inflammatory cytokine, interleukin-10 (IL-10), has roles in systemic inflammation.
Aksoyer Sezgin Saadet Busra, Bayoglu Burcu, Ersoz Feyzullah, Sarici Murat, Niyazoglu Mutlu, Dirican Ahmet, Cengiz Müjgan   +6 more
doaj   +1 more source

Insights into the mechanism of cyanobacteria removal by the algicidal fungi Bjerkandera adusta and Trametes versicolor

MicrobiologyOpen, 2020
Fungal mycelia can eliminate almost all cocultured cyanobacterial cells within a short time. However, molecular mechanisms of algicidal fungi are poorly understood.
Guomin Han, Hui Ma, Shenrong Ren, Xueyan Gao, Xiaolong He, Suwen Zhu, Ruining Deng, Shihua Zhang   +7 more
doaj   +1 more source

Computational investigation of conformational variability and allostery in cathepsin K and other related peptidases.

PLoS ONE, 2017
Allosteric targeting is progressively gaining ground as a strategy in drug design. Its success, however, depends on our knowledge of the investigated system.
Marko Novinec
doaj   +1 more source

Frozen fresh blood plasma preserves the functionality of native human α2-macroglobulin

Scientific Reports, 2023
Human α2-macroglobulin (hα2M) is a large homotetrameric protein involved in the broad inhibition of endopeptidases. Following cleavage within a bait region, hα2M undergoes stepwise transitions from its native, expanded, highly flexible, active ...
Soraia R. Mendes, F. Xavier Gomis-Rüth, Theodoros Goulas   +2 more
doaj   +1 more source

Pharmaceutically modified subtilisins withstand acidic conditions and effectively degrade gluten in vivo [PDF]

, 2019
Detoxification of gluten immunogenic epitopes is a promising strategy for the treatment of celiac disease. Our previous studies have shown that these epitopes can be degraded in vitro by subtilisin enzymes derived from Rothia mucilaginosa, a natural ...
Darwish, Ghassan, Helmerhorst, Eva J., Oppenheim, Frank G., Schuppan, Detlef, Wei, Guoxian   +4 more
core   +1 more source

Glutamyl Endopeptidases: The Puzzle of Substrate Specificity

Acta Naturae, 2017
Glutamyl endopeptidases (GEPases) are chymotrypsin-like enzymes that preferentially cleave the peptide bonds of the α-carboxyl groups of glutamic acid.
I. Demidyuk, K. N. Chukhontseva, S. Kostrov   +2 more
semanticscholar   +1 more source

Filling the Gaps to Solve the Extensin Puzzle [PDF]

, 2018
Extensins (EXTs) are highly repetitive plant O-glycoproteins that require several post-translational modifications (PTMs) to become functional in plant cell walls.
Borassi, Cecilia, Bringas, Mauro, Capece, Luciana, Estevez, Jose Manuel, Marzol, Eliana, Rodríguez Garcia, Diana Rosa, Sede, Ana Rocío   +6 more
core   +1 more source

A Systematic Approach to the Comparison of Cost Efficiency of Endopeptidases for the Hydrolysis of Atlantic Salmon (Salmo salar) By-Products.

Food Technology and Biotechnology, 2016
The hydrolytic and cost efficiencies of five endopeptidases (Alcalase 2.4L, Corolase 7089, Neutrase 0.8L, Promod 671L and Protex 7L) to hydrolyze Atlantic salmon by-products were compared at standardized activity levels based on a casein assay.
T. Aspevik, Henning Egede-Nissen, Ĺge Oterhals   +2 more
semanticscholar   +1 more source

Amyloid beta and Alzheimer’s Disease: The role of neprilysin-2 in amyloid-beta clearance

Frontiers in Aging Neuroscience, 2014
Accumulation of the amyloid-beta (Ab) peptide is a central factor in Alzheimer’s disease (AD) pathogenesis as supported by continuing evidence. This review concisely summarizes this evidence supporting a critical role for Ab in AD before discussing the ...
Robert eMarr, Daniel eHafez
doaj   +1 more source