Results 61 to 70 of about 34,911 (258)
Characterization and Analysis of PHEX Variants in Patients With Hypophosphatemia in Argentina
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Confirming the underlying molecular etiology of hereditary hypophosphatemia (HH) to provide recurrence risk counseling is highly important. Our aims were to describe the detected variants and their distribution across Argentina and to contrast them with published data.
Silvia Ávila +3 more
wiley +1 more source
, 2020 Cell division in most bacteria is orchestrated by a complex of proteins organized in a ring-shaped structure at midcell known as the divisome or septal ring. In Gram-negative bacteria such as Escherichia coli, this fundamental biological process involves
Truong, Thao
core +4 more sources
Involvement of Arabidopsis thaliana endoplasmic reticulum KDEL-tailed cysteine endopeptidase 1 (AtCEP1) in powdery mildew-induced and AtCPR5-controlled cell death. [PDF]
PLoS ONE, 2017 Programmed cell death (PCD) is a prerequisite for successful development and it limits the spread of biotrophic pathogens in a rapid hypersensitive response at the site of infection.
Timo Höwing +4 more
doaj +1 more source
Current Research in Microbial Sciences, 2021 Pro-Pro-endopeptidases (PPEP, EC 3.4.24.89) are secreted, zinc metalloproteases that have the unusual capacity to cleave a peptide bond between two prolines, a bond that is generally less sensitive to proteolytic cleavage. Two well studied members of the
Hans C van Leeuwen +3 more
doaj +1 more source
Identification of the active site of legumain links it to caspases, clostripain and gingipains in a new clan of cysteine endopeptidases [PDF]
, 1998 We show by site-directed mutagenesis that the catalytic residues of mammalian legumain, a recently discovered lysosomal asparaginycysteine endopeptidase, form a catalytic dyad in the motif His-Gly-spacer-Ala-Cys. We note that the same motif is present in
Stevens, Richard A.E. +7 more
core +1 more source
Current and emerging therapy for celiac disease
Frontiers in Medicine, 2014 At present, strict and lifelong gluten free diet is the only effective treatment for celiac disease. Even small amounts of gluten (50mg/day) can be immunogenic; therefore all food and food items and drugs that contain gluten and its derivatives must be ...
Govind K Makharia
doaj +1 more source
PLoS ONE, 2021 Pseudomonas aeruginosa secretes several endopeptidases, including elastase, alkaline proteinase (Apr), a lysine-specific endopeptidase (LysC), and an aminopeptidase (PaAP), all of which are important virulence factors.
Itschak Axelrad +5 more
doaj +1 more source
Specificity of prolyl endopeptidase [PDF]
FEBS Letters, 1986 A series of tetrapeptides, Cbz(Bz)‐Gly‐X‐Leu‐Gly, were synthesized and the kinetic parameters, k cat and , determined for their hydrolyses by prolyl endopeptidase from Flavobacterium. The peptides with X = N‐Me‐Ala, Sar and Ala as well as the standard substrate (X = Pro) were found to be good substrates, while those with X = α‐aminobutyryl, Hyp, Ser ...
openaire +2 more sources
Endopeptidases and prohormone processing
Bioscience Reports, 1990 Peptide hormones and peptide transmitters are generated from polypeptide precursors by specific cleavage reactions which take place principally at sites formed by single or paired basic residues. Not all the possible cleavage sites are utilised, however, and the degree of processing of many propeptides has been found to vary according to the tissue of ...
N J, Darby, D G, Smyth
openaire +2 more sources
Pathogens, 2013 Matrix metalloproteinases (MMPs) represent a large family of over twenty different secreted or membrane-bound endopeptidases, involved in many physiological (embryogenesis, precursor or stem cell mobilization, tissue remodeling during wound healing, etc.)
Fabrizio Bruschi, Barbara Pinto
doaj +1 more source