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THE ENDOPLASMIC RETICULUM [PDF]
The Journal of Cell Biology, 1956 and (b) the vesicular character of its component elements, were already clearly noted in its first description. In subsequent papers, Porter and his collaborators described the preferential concentration of the vesicular elements of the reticulum in the endoplasm, and their scarcity or absence in the supposedly exoplasmic periphery of the cytoplasm (2,
George E. Palade
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Research progress on the role of endoplasmic reticulum stress in osteoarthritis [PDF]
Jichu yixue yu linchuang, 2023 Osteoarthritis is a common degenerative disease in which endoplasmic reticulum stress(ER stress) plays an important role in the pathogenesis of chondrocyte apoptosis.
JIN Tao, YANG Qingshan, WU Shujin, ZHU Xiaoyan, SHI Yucong, NIU Jianxiong, LIU Lin
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Endoplasmic reticulum stress: molecular mechanism and therapeutic targets
Signal Transduction and Targeted Therapy, 2023 The endoplasmic reticulum (ER) functions as a quality-control organelle for protein homeostasis, or “proteostasis”. The protein quality control systems involve ER-associated degradation, protein chaperons, and autophagy.
Xingyi Chen +4 more
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Protein quality control and aggregation in the endoplasmic reticulum: From basic to bedside
Frontiers in Cell and Developmental Biology, 2023 Endoplasmic reticulum (ER) is the largest membrane-bound compartment in all cells and functions as a key regulator in protein biosynthesis, lipid metabolism, and calcium balance.
Guofang Chen +5 more
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Endoplasmic Reticulum Stress in Liver Diseases.
Hepatology, 2022 The endoplasmic reticulum (ER) is an intracellular organelle that fosters the correct folding of linear polypeptides and proteins, a process tightly governed by the ER-resident enzymes and chaperones.
Amir Ajoolabady +6 more
semanticscholar +1 more source
Endoplasmic reticulum stress-mediated cell death in liver injury
Cell Death and Disease, 2022 The endoplasmic reticulum is an important intracellular organelle that plays an important role in maintaining cellular homeostasis. Endoplasmic reticulum stress (ERS) and unfolded protein response (UPR) are induced when the body is exposed to adverse ...
Jian Zhang +5 more
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Antioxidants, 2023 The endoplasmic reticulum is a subcellular organelle key in the control of synthesis, folding, and sorting of proteins. Under endoplasmic reticulum stress, an adaptative unfolded protein response is activated; however, if this activation is prolonged ...
Alexis Martinez +16 more
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Prediction of endoplasmic reticulum resident proteins using fragmented amino acid composition and support vector machine [PDF]
PeerJ, 2017 Background The endoplasmic reticulum plays an important role in many cellular processes, which includes protein synthesis, folding and post-translational processing of newly synthesized proteins.
Ravindra Kumar +2 more
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Mitochondrial-Endoplasmic Reticulum Communication-Mediated Oxidative Stress and Autophagy
BioMed Research International, 2022 Oxidative stress is an imbalance between free radicals and the antioxidant system causing overgeneration of free radicals (oxygen-containing molecules) ultimately leading to oxidative damage in terms of lipid peroxidation, protein denaturation, and DNA ...
Xiao-qing Liu +5 more
semanticscholar +1 more source
Modeling calcium dynamics in neurons with endoplasmic reticulum: existence, uniqueness and an implicit-explicit finite element scheme [PDF]
, 2021 Like many other biological processes, calcium dynamics in neurons containing an endoplasmic reticulum are governed by diffusion-reaction equations on interface-separated domains. Interface conditions are typically described by systems of ordinary differential equations that provide fluxes across the interfaces.
arxiv +1 more source