Results 1 to 10 of about 349,870 (296)
THE ENDOPLASMIC RETICULUM [PDF]
The Journal of Cell Biology, 1956 and (b) the vesicular character of its component elements, were already clearly noted in its first description. In subsequent papers, Porter and his collaborators described the preferential concentration of the vesicular elements of the reticulum in the endoplasm, and their scarcity or absence in the supposedly exoplasmic periphery of the cytoplasm (2,
George E. Palade
openalex +4 more sources
Endoplasmic reticulum stress in lung cancer [PDF]
Frontiers in OncologyEndoplasmic reticulum is the primary site of eukaryotic cells involved in biosynthesis, lipid metabolism, glucose metabolism, protein folding and secretion.
Donghuan Zhang +6 more
doaj +2 more sources
Research progress on the role of endoplasmic reticulum stress in osteoarthritis [PDF]
Jichu yixue yu linchuang, 2023 Osteoarthritis is a common degenerative disease in which endoplasmic reticulum stress(ER stress) plays an important role in the pathogenesis of chondrocyte apoptosis.
JIN Tao, YANG Qingshan, WU Shujin, ZHU Xiaoyan, SHI Yucong, NIU Jianxiong, LIU Lin
doaj +1 more source
Protein quality control and aggregation in the endoplasmic reticulum: From basic to bedside
Frontiers in Cell and Developmental Biology, 2023 Endoplasmic reticulum (ER) is the largest membrane-bound compartment in all cells and functions as a key regulator in protein biosynthesis, lipid metabolism, and calcium balance.
Guofang Chen +5 more
doaj +1 more source
Prediction of endoplasmic reticulum resident proteins using fragmented amino acid composition and support vector machine [PDF]
PeerJ, 2017 Background The endoplasmic reticulum plays an important role in many cellular processes, which includes protein synthesis, folding and post-translational processing of newly synthesized proteins.
Ravindra Kumar +2 more
doaj +2 more sources
Antioxidants, 2023 The endoplasmic reticulum is a subcellular organelle key in the control of synthesis, folding, and sorting of proteins. Under endoplasmic reticulum stress, an adaptative unfolded protein response is activated; however, if this activation is prolonged ...
Alexis Martinez +16 more
doaj +1 more source
Endoplasmic Reticulum Stress in Malignancy [PDF]
Cancer Cell, 2014 The combination of relative nutrient deprivation and dysregulation of protein synthesis make malignant cells especially prone to protein misfolding. Endoplasmic reticulum stress, which results from protein misfolding within the secretory pathway, has a profound effect on cancer cell proliferation and survival.
Clarke, Hanna J +3 more
openaire +3 more sources
Endoplasmic reticulum stress and pulmonary hypertension
Pulmonary Circulation, 2020 Pulmonary hypertension is a fatal disease of which pulmonary vasculopathy is the main pathological feature resulting in the mean pulmonary arterial pressure higher than 25 mmHg.
Yanan Hu +5 more
doaj +1 more source
Journal of Inflammation, 2023 Background Soluble Epoxide Hydrolase (sEH) metabolizes anti-inflammatory epoxyeicosatrienoic acids and critically affects airway inflammation in chronic obstructive pulmonary disease (COPD).
Yue Yu +9 more
doaj +1 more source
Construction of the endoplasmic reticulum. [PDF]
The Journal of cell biology, 1989 To study the construction of the ER, we used the microtubule-disrupting drug nocodazole to induce the complete breakdown of ER structure in living cells followed by recovery in drug-free medium, which regenerates the ER network within 15 min. Using the fluorescent dye 3,3'-dihexyloxacarbocyanine iodide to visualize the ER, we have directly observed the
Michael A. J. Ferguson +2 more
openaire +2 more sources