Results 1 to 10 of about 605,400 (330)

c-Abl Phosphorylates MFN2 to Regulate Mitochondrial Morphology in Cells under Endoplasmic Reticulum and Oxidative Stress, Impacting Cell Survival and Neurodegeneration [PDF]

Antioxidants, 2023
The endoplasmic reticulum is a subcellular organelle key in the control of synthesis, folding, and sorting of proteins. Under endoplasmic reticulum stress, an adaptative unfolded protein response is activated; however, if this activation is prolonged ...
Alexis Martinez, Cristian M. Lamaizon, Cristian Valls, Fabien Llambi, Nancy Leal, Patrick Fitzgerald, Cliff Guy, Marcin M. Kamiński, Nibaldo C. Inestrosa, Brigitte van Zundert, Gonzalo I. Cancino, Andrés E. Dulcey, Silvana Zanlungo, Juan J. Marugan, Claudio Hetz, Douglas R. Green, Alejandra R. Alvarez   +16 more
doaj   +2 more sources

Endoplasmic reticulum stress in lung cancer [PDF]

Frontiers in Oncology
Endoplasmic reticulum is the primary site of eukaryotic cells involved in biosynthesis, lipid metabolism, glucose metabolism, protein folding and secretion.
Donghuan Zhang, Lanlan Lin, Hui Jin, Huajun Mao, Luying Wang, Wenwen Ma, Zhenghong Lao   +6 more
doaj   +2 more sources

Modulation of endoplasmic reticulum stress–induced insulin resistance by the low-carbohydrate high-fat ketogenic diet [PDF]

Frontiers in Nutrition
This review aimed to investigate the relationship between endoplasmic reticulum (ER) stress, insulin resistance, and the potential mitigating effects of a low-carbohydrate, high-fat diet, Ketogenic diet (LCHF-KD).
Basmah M. Eldakhakhny, Basmah M. Eldakhakhny, Fatma M. Ghoneim, Yousef M. Almoghrabi, Yousef M. Almoghrabi, Ghada Ajabnoor, Ghada Ajabnoor, Faisal Alandejani, Faisal Alandejani, Salwa M. Abo El-Khair, Salma A. Elsamanoudy, Taghreed Shamrani, Moaaz A. Siddiqui, Ayman Z. Elsamanoudy, Ayman Z. Elsamanoudy, Ayman Z. Elsamanoudy   +15 more
doaj   +2 more sources

Research progress on the role of endoplasmic reticulum stress in osteoarthritis [PDF]

Jichu yixue yu linchuang, 2023
Osteoarthritis is a common degenerative disease in which endoplasmic reticulum stress(ER stress) plays an important role in the pathogenesis of chondrocyte apoptosis.
JIN Tao, YANG Qingshan, WU Shujin, ZHU Xiaoyan, SHI Yucong, NIU Jianxiong, LIU Lin
doaj   +1 more source

Protein quality control and aggregation in the endoplasmic reticulum: From basic to bedside

Frontiers in Cell and Developmental Biology, 2023
Endoplasmic reticulum (ER) is the largest membrane-bound compartment in all cells and functions as a key regulator in protein biosynthesis, lipid metabolism, and calcium balance.
Guofang Chen, Tingyi Wei, Tingyi Wei, Furong Ju, Haisen Li, Haisen Li   +5 more
doaj   +1 more source

Uterine Endoplasmic Reticulum Stress and Its Unfolded Protein Response May Regulate Caspase 3 Activation in the Pregnant Mouse Uterus [PDF]

, 2013
We have previously proposed that uterine caspase-3 may modulate uterine contractility in a gestationally regulated fashion. The objective of this study was to determine the mechanism by which uterine caspase-3 is activated and consequently controlled in ...
Condon, Jennifer C., Jeyasuria, Pancharatnam, Kyathanahalli, Chandrashekara, Lydon, John P., Subedi, Kalpana, Suresh, Arvind   +5 more
core   +10 more sources

Prediction of endoplasmic reticulum resident proteins using fragmented amino acid composition and support vector machine [PDF]

PeerJ, 2017
Background The endoplasmic reticulum plays an important role in many cellular processes, which includes protein synthesis, folding and post-translational processing of newly synthesized proteins.
Ravindra Kumar, Bandana Kumari, Manish Kumar   +2 more
doaj   +2 more sources

Cytosolic chaperones influence the fate of a toxin dislocated from the endoplasmic reticulum [PDF]

, 2008
The plant cytotoxin ricin enters target mammalian cells by receptor-mediated endocytosis and undergoes retrograde transport to the endoplasmic reticulum (ER).
Argent, Argent, Arndt, Brodsky, Brodsky, C. Rogon, Chaddock, Chen, Hudson, Hundley, H  hfeld, J. Hohfeld, J. M. Lord, J. P. Cook, L. M. Roberts, Lawson, Luders, Meacham, Meusser, Nakatsukasa, Nakatsukasa, P. J. Hart, P. Pietroni, R. A. Spooner, Rapak, Roe, Savino, Spooner, Urushitani, van Deurs, Wales, Wesche, Younger   +32 more
core   +4 more sources

Endoplasmic reticulum stress and pulmonary hypertension

Pulmonary Circulation, 2020
Pulmonary hypertension is a fatal disease of which pulmonary vasculopathy is the main pathological feature resulting in the mean pulmonary arterial pressure higher than 25 mmHg.
Yanan Hu, Wenhao Yang, Liang Xie, Tao Liu, Hanmin Liu, Bin Liu   +5 more
doaj   +1 more source

Soluble epoxide hydrolase deficiency attenuates airway inflammation in COPD via IRE1α/JNK/AP-1 signaling pathway

Journal of Inflammation, 2023
Background Soluble Epoxide Hydrolase (sEH) metabolizes anti-inflammatory epoxyeicosatrienoic acids and critically affects airway inflammation in chronic obstructive pulmonary disease (COPD).
Yue Yu, Ailin Yang, Xin He, Bo Wu, Yanjun Wu, Yunxiao Li, Shan Nie, Bo Xu, Haoyan Wang, Ganggang Yu   +9 more
doaj   +1 more source