Results 1 to 10 of about 356,983 (328)

Endoplasmic reticulum stress in lung disease [PDF]

European Respiratory Review, 2017
Exposure to inhaled pollutants, including fine particulates and cigarette smoke is a major cause of lung disease in Europe. While it is established that inhaled pollutants have devastating effects on the genome, it is now recognised that additional ...
Stefan J. Marciniak
doaj   +7 more sources

Endoplasmic reticulum stress in lung cancer [PDF]

Frontiers in Oncology
Endoplasmic reticulum is the primary site of eukaryotic cells involved in biosynthesis, lipid metabolism, glucose metabolism, protein folding and secretion.
Donghuan Zhang, Lanlan Lin, Hui Jin, Huajun Mao, Luying Wang, Wenwen Ma, Zhenghong Lao   +6 more
doaj   +2 more sources

Modulation of endoplasmic reticulum stress–induced insulin resistance by the low-carbohydrate high-fat ketogenic diet [PDF]

Frontiers in Nutrition
This review aimed to investigate the relationship between endoplasmic reticulum (ER) stress, insulin resistance, and the potential mitigating effects of a low-carbohydrate, high-fat diet, Ketogenic diet (LCHF-KD).
Basmah M. Eldakhakhny, Basmah M. Eldakhakhny, Fatma M. Ghoneim, Yousef M. Almoghrabi, Yousef M. Almoghrabi, Ghada Ajabnoor, Ghada Ajabnoor, Faisal Alandejani, Faisal Alandejani, Salwa M. Abo El-Khair, Salma A. Elsamanoudy, Taghreed Shamrani, Moaaz A. Siddiqui, Ayman Z. Elsamanoudy, Ayman Z. Elsamanoudy, Ayman Z. Elsamanoudy   +15 more
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Endoplasmic Reticulum Stress in Cancer [PDF]

MedComm
Persistent and intense endoplasmic reticulum (ER) stress is widely acknowledged as a hallmark of tumorigenesis. To restore ER homeostasis, cells activate the unfolded protein response (UPR), which is aberrantly regulated in cancer cells.
Ruixin Zhou, Wenlong Wang, Baizhao Li, Zhu Li, Juan Huang, Xinying Li   +5 more
doaj   +2 more sources

Endoplasmic reticulum stress in diseases

MedComm
The endoplasmic reticulum (ER) is a key organelle in eukaryotic cells, responsible for a wide range of vital functions, including the modification, folding, and trafficking of proteins, as well as the biosynthesis of lipids and the maintenance of ...
Yingying Liu, Chunling Xu, Renjun Gu, Ruiqin Han, Ziyun Li, Xianrong Xu   +5 more
doaj   +3 more sources

Research progress on the role of endoplasmic reticulum stress in osteoarthritis [PDF]

Jichu yixue yu linchuang, 2023
Osteoarthritis is a common degenerative disease in which endoplasmic reticulum stress(ER stress) plays an important role in the pathogenesis of chondrocyte apoptosis.
JIN Tao, YANG Qingshan, WU Shujin, ZHU Xiaoyan, SHI Yucong, NIU Jianxiong, LIU Lin
doaj   +1 more source

Uterine Endoplasmic Reticulum Stress and Its Unfolded Protein Response May Regulate Caspase 3 Activation in the Pregnant Mouse Uterus [PDF]

, 2013
We have previously proposed that uterine caspase-3 may modulate uterine contractility in a gestationally regulated fashion. The objective of this study was to determine the mechanism by which uterine caspase-3 is activated and consequently controlled in ...
Condon, Jennifer C., Jeyasuria, Pancharatnam, Kyathanahalli, Chandrashekara, Lydon, John P., Subedi, Kalpana, Suresh, Arvind   +5 more
core   +13 more sources

c-Abl Phosphorylates MFN2 to Regulate Mitochondrial Morphology in Cells under Endoplasmic Reticulum and Oxidative Stress, Impacting Cell Survival and Neurodegeneration

Antioxidants, 2023
The endoplasmic reticulum is a subcellular organelle key in the control of synthesis, folding, and sorting of proteins. Under endoplasmic reticulum stress, an adaptative unfolded protein response is activated; however, if this activation is prolonged ...
Alexis Martinez, Cristian M. Lamaizon, Cristian Valls, Fabien Llambi, Nancy Leal, Patrick Fitzgerald, Cliff Guy, Marcin M. Kamiński, Nibaldo C. Inestrosa, Brigitte van Zundert, Gonzalo I. Cancino, Andrés E. Dulcey, Silvana Zanlungo, Juan J. Marugan, Claudio Hetz, Douglas R. Green, Alejandra R. Alvarez   +16 more
doaj   +1 more source

Endoplasmic Reticulum Stress and Inflammation [PDF]

Digestive Diseases, 2012
Endoplasmic reticulum (ER) stress due to the presence of misfolded or unfolded proteins in the ER invokes a fundamental biological response, termed the unfolded protein response (UPR). The UPR is orchestrated by three main proximal effectors, of which the IRE1/XBP1 pathway represents the evolutionarily most conserved one.
Adolph TE, Niederreiter L, Blumberg RS, Kaser A   +3 more
openaire   +2 more sources

Epithelial-mesenchymal transition induces endoplasmic-reticulum-stress response in human colorectal tumor cells. [PDF]

PLoS ONE, 2014
Tumor cells are stressed by unfavorable environmental conditions like hypoxia or starvation. Driven by the resulting cellular stress tumor cells undergo epithelial-mesenchymal transition.
Evelyn Zeindl-Eberhart, Lydia Brandl, Sibylle Liebmann, Steffen Ormanns, Silvio K Scheel, Thomas Brabletz, Thomas Kirchner, Andreas Jung   +7 more
doaj   +1 more source