Results 1 to 10 of about 145,884 (93)

Endoplasmic reticulum stress in lung disease [PDF]

European Respiratory Review, 2017
Exposure to inhaled pollutants, including fine particulates and cigarette smoke is a major cause of lung disease in Europe. While it is established that inhaled pollutants have devastating effects on the genome, it is now recognised that additional ...
Stefan J. Marciniak
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Research progress on the role of endoplasmic reticulum stress in osteoarthritis [PDF]

Jichu yixue yu linchuang, 2023
Osteoarthritis is a common degenerative disease in which endoplasmic reticulum stress(ER stress) plays an important role in the pathogenesis of chondrocyte apoptosis.
JIN Tao, YANG Qingshan, WU Shujin, ZHU Xiaoyan, SHI Yucong, NIU Jianxiong, LIU Lin
doaj   +1 more source

c-Abl Phosphorylates MFN2 to Regulate Mitochondrial Morphology in Cells under Endoplasmic Reticulum and Oxidative Stress, Impacting Cell Survival and Neurodegeneration

Antioxidants, 2023
The endoplasmic reticulum is a subcellular organelle key in the control of synthesis, folding, and sorting of proteins. Under endoplasmic reticulum stress, an adaptative unfolded protein response is activated; however, if this activation is prolonged ...
Alexis Martinez, Cristian M. Lamaizon, Cristian Valls, Fabien Llambi, Nancy Leal, Patrick Fitzgerald, Cliff Guy, Marcin M. Kamiński, Nibaldo C. Inestrosa, Brigitte van Zundert, Gonzalo I. Cancino, Andrés E. Dulcey, Silvana Zanlungo, Juan J. Marugan, Claudio Hetz, Douglas R. Green, Alejandra R. Alvarez   +16 more
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Epithelial-mesenchymal transition induces endoplasmic-reticulum-stress response in human colorectal tumor cells. [PDF]

PLoS ONE, 2014
Tumor cells are stressed by unfavorable environmental conditions like hypoxia or starvation. Driven by the resulting cellular stress tumor cells undergo epithelial-mesenchymal transition.
Evelyn Zeindl-Eberhart, Lydia Brandl, Sibylle Liebmann, Steffen Ormanns, Silvio K Scheel, Thomas Brabletz, Thomas Kirchner, Andreas Jung   +7 more
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Uterine Endoplasmic Reticulum Stress and Its Unfolded Protein Response May Regulate Caspase 3 Activation in the Pregnant Mouse Uterus [PDF]

, 2013
We have previously proposed that uterine caspase-3 may modulate uterine contractility in a gestationally regulated fashion. The objective of this study was to determine the mechanism by which uterine caspase-3 is activated and consequently controlled in ...
Condon, Jennifer C., Jeyasuria, Pancharatnam, Kyathanahalli, Chandrashekara, Lydon, John P., Subedi, Kalpana, Suresh, Arvind   +5 more
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Soluble epoxide hydrolase deficiency attenuates airway inflammation in COPD via IRE1α/JNK/AP-1 signaling pathway

Journal of Inflammation, 2023
Background Soluble Epoxide Hydrolase (sEH) metabolizes anti-inflammatory epoxyeicosatrienoic acids and critically affects airway inflammation in chronic obstructive pulmonary disease (COPD).
Yue Yu, Ailin Yang, Xin He, Bo Wu, Yanjun Wu, Yunxiao Li, Shan Nie, Bo Xu, Haoyan Wang, Ganggang Yu   +9 more
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Endoplasmic reticulum stress and pulmonary hypertension

Pulmonary Circulation, 2020
Pulmonary hypertension is a fatal disease of which pulmonary vasculopathy is the main pathological feature resulting in the mean pulmonary arterial pressure higher than 25 mmHg.
Yanan Hu, Wenhao Yang, Liang Xie, Tao Liu, Hanmin Liu, Bin Liu   +5 more
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Cigarette smoke toxin hydroquinone and misfolding pancreatic lipase variant cooperatively promote endoplasmic reticulum stress and cell death.

PLoS ONE, 2022
Mutation-induced protein misfolding of pancreatic secretory enzymes and consequent endoplasmic reticulum stress can cause chronic pancreatitis. A recent study revealed that cigarette smoke also increases the risk of the disease through endoplasmic ...
Norbert Kassay, Vanda Toldi, József Tőzsér, András Szabó   +3 more
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Endoplasmic reticulum as a target in cardiovascular diseases: Is there a role for flavonoids?

Frontiers in Pharmacology, 2023
Flavonoids are found in natural health products and plant-based foods. The flavonoid molecules contain a 15-carbon skeleton with the particular structural construction of subclasses.
Kimia Keylani, Fariba Arbab Mojeni, Amirmohammad Khalaji, Asma Rasouli, Dlnya Aminzade, Mohammad Amin Karimi, Pantea Majma Sanaye, Nazanin Khajevand, Nasrin Nemayandeh, Mohadeseh Poudineh, Mehdi Azizabadi Farahani, Mohammad Ali Esfandiari, Sepehr Haghshoar, Ali Kheirandish, Erfan Amouei, Amir Abdi, Arash Azizinezhad, Afshin Khani, Niloofar Deravi   +18 more
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Stress-induced neuroprotective effects of epiregulin and amphiregulin. [PDF]

PLoS ONE, 2015
Members of the epidermal growth factor family play important roles in the regulation of cell growth, proliferation, and survival. However, the specific roles of each epidermal growth factor family member with respect to brain injury are not well ...
Libin Zhan, Luping Zheng, Toru Hosoi, Yasunobu Okuma, Yasuyuki Nomura   +4 more
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