Results 11 to 20 of about 146,033 (236)

Endoplasmic reticulum stress and organoids [PDF]

Organoid, 2021
Organoids represent an advanced tool in cell biology and have redefined biomedical research. Organoids are ideal for studies of biological processes, pharmacological studies, and therapeutic research to imitate pathological processes and preserve genetic
Rashedul Alam, Mohammad Mamun Ur Rashid, Mohammad Fazlul Kabir, Hyung-Ryong Kim   +3 more
doaj   +4 more sources

Endoplasmic reticulum stress in diseases

MedComm
The endoplasmic reticulum (ER) is a key organelle in eukaryotic cells, responsible for a wide range of vital functions, including the modification, folding, and trafficking of proteins, as well as the biosynthesis of lipids and the maintenance of ...
Yingying Liu, Chunling Xu, Renjun Gu, Ruiqin Han, Ziyun Li, Xianrong Xu   +5 more
doaj   +3 more sources

Endoplasmic Reticulum Stress in Malignancy [PDF]

Cancer Cell, 2014
The combination of relative nutrient deprivation and dysregulation of protein synthesis make malignant cells especially prone to protein misfolding. Endoplasmic reticulum stress, which results from protein misfolding within the secretory pathway, has a profound effect on cancer cell proliferation and survival.
Clarke, Hanna J, Chambers, Joseph E, Liniker, Elizabeth, Marciniak, Stefan J   +3 more
openaire   +3 more sources

Endoplasmic Reticulum Stress and Inflammation [PDF]

Digestive Diseases, 2012
Endoplasmic reticulum (ER) stress due to the presence of misfolded or unfolded proteins in the ER invokes a fundamental biological response, termed the unfolded protein response (UPR). The UPR is orchestrated by three main proximal effectors, of which the IRE1/XBP1 pathway represents the evolutionarily most conserved one.
Adolph TE, Niederreiter L, Blumberg RS, Kaser A   +3 more
openaire   +3 more sources

Endoplasmic Reticulum Stress and Cancer [PDF]

Journal of Cancer Prevention, 2014
The endoplasmic reticulum (ER) is the principal organelle responsible for multiple cellular functions including protein folding and maturation and the maintenance of cellular homeostasis. ER stress is activated by a variety of factors and triggers the unfolded protein response (UPR), which restores homeostasis or activates cell death.
Raj Kumar Yadav, Han-Jung Chae, Hyung-Ryong Kim, Soo-Wan Chae   +3 more
openaire   +3 more sources

Endoplasmic reticulum stress and apoptosis [PDF]

Cellular and Molecular Biology Letters, 2006
AbstractCell death is an essential event in normal life and development, as well as in the pathophysiological processes that lead to disease. It has become clear that each of the main cellular organelles can participate in cell death signalling pathways, and recent advances have highlighted the importance of the endoplasmic reticulum (ER) in cell death
Jitka Faitova, Roman Hrstka, Daniel Krekac, Borivoj Vojtesek   +3 more
openaire   +3 more sources

ENDOPLASMIC RETICULUM STRESS IN SEPSIS [PDF]

Shock, 2015
Sepsis is an enormous public health issue and the leading cause of death in critically ill patients in intensive care units. Overwhelming inflammation, characterized by cytokine storm, oxidative threats, and neutrophil sequestration, is an underlying component of sepsis-associated organ failure.
Weng Lang Yang, Weng Lang Yang, Ping Wang, Ping Wang, Mohammad Moshahid Khan   +4 more
openaire   +3 more sources

Inhibition of endoplasmic reticulum stress alleviates secondary injury after traumatic brain injury

Neural Regeneration Research, 2018
Apoptosis after traumatic brain injury has been shown to be a major factor influencing prognosis and outcome. Endoplasmic reticulum stress may be involved in mitochondrial mediated neuronal apoptosis. Therefore, endoplasmic reticulum stress has become an
Hong-Ping Tan, Qiang Guo, Gang Hua, Jun-Xi Chen, Jun-Chao Liang   +4 more
doaj   +1 more source

RBM10 Regulates Embryonic Trophoblast Injury via Endoplasmic Reticulum Stress

Clinical and Experimental Obstetrics & Gynecology, 2022
Background: Previous studies shown that RNA binding motif proteins (RBM) participate in regulating various physiological processes such as cell autophagy, proliferation, and apoptosis, and are abnormally highly expressed in placental trophoblast cells ...
Xiao Chen, Juan Du, Liyu Chen, Lanlan Wang, Gang Xin   +4 more
doaj   +1 more source

Estrogens promote misfolded proinsulin degradation to protect insulin production and delay diabetes [PDF]

, 2018
Summary: Conjugated estrogens (CE) delay the onset of type 2 diabetes (T2D) in postmenopausal women, but the mechanism is unclear. In T2D, the endoplasmic reticulum (ER) fails to promote proinsulin folding and, in failing to do so, promotes ER stress and
Allard, Camille, Alvarez-Mercado, Ana I, Arvan, Peter, Coons, Laurel A, Floyd, Z. Elizabeth, Fuselier, Taylor, Hewitt, Sylvia C, Kim, Jun Ho, Korach, Kenneth S, Levin, Ellis R, Mauvais-Jarvis, Franck, Urano, Fumihiko, Xu, Beibei   +12 more
core   +2 more sources