Results 11 to 20 of about 356,983 (328)

Soluble epoxide hydrolase deficiency attenuates airway inflammation in COPD via IRE1α/JNK/AP-1 signaling pathway

Journal of Inflammation, 2023
Background Soluble Epoxide Hydrolase (sEH) metabolizes anti-inflammatory epoxyeicosatrienoic acids and critically affects airway inflammation in chronic obstructive pulmonary disease (COPD).
Yue Yu, Ailin Yang, Xin He, Bo Wu, Yanjun Wu, Yunxiao Li, Shan Nie, Bo Xu, Haoyan Wang, Ganggang Yu   +9 more
doaj   +1 more source

Endoplasmic reticulum stress and pulmonary hypertension

Pulmonary Circulation, 2020
Pulmonary hypertension is a fatal disease of which pulmonary vasculopathy is the main pathological feature resulting in the mean pulmonary arterial pressure higher than 25 mmHg.
Yanan Hu, Wenhao Yang, Liang Xie, Tao Liu, Hanmin Liu, Bin Liu   +5 more
doaj   +1 more source

Endoplasmic reticulum as a target in cardiovascular diseases: Is there a role for flavonoids?

Frontiers in Pharmacology, 2023
Flavonoids are found in natural health products and plant-based foods. The flavonoid molecules contain a 15-carbon skeleton with the particular structural construction of subclasses.
Kimia Keylani, Fariba Arbab Mojeni, Amirmohammad Khalaji, Asma Rasouli, Dlnya Aminzade, Mohammad Amin Karimi, Pantea Majma Sanaye, Nazanin Khajevand, Nasrin Nemayandeh, Mohadeseh Poudineh, Mehdi Azizabadi Farahani, Mohammad Ali Esfandiari, Sepehr Haghshoar, Ali Kheirandish, Erfan Amouei, Amir Abdi, Arash Azizinezhad, Afshin Khani, Niloofar Deravi   +18 more
doaj   +1 more source

Endoplasmic reticulum stress and apoptosis [PDF]

Cellular and Molecular Biology Letters, 2006
AbstractCell death is an essential event in normal life and development, as well as in the pathophysiological processes that lead to disease. It has become clear that each of the main cellular organelles can participate in cell death signalling pathways, and recent advances have highlighted the importance of the endoplasmic reticulum (ER) in cell death
Faitova, Jitka, Krekac, Daniel, Hrstka, Roman, Vojtesek, Borivoj   +3 more
openaire   +2 more sources

Endoplasmic Reticulum Stress Response [PDF]

, 2011
The endoplasmic reticulum (ER) is a key organelle that serves as the gateway for newly synthesized proteins into the secretory pathway. Following synthesis, secretory proteins are exported from the ER to various cellular compartments where they fulfill their inherent biological roles. The correct trafficking of proteins through the secretory pathway is
Reis, Pedro Augusto B., Soares-Ramos, Juliana R.L., Fontes, Elizabeth P.B.   +2 more
  +8 more sources

Cigarette smoke toxin hydroquinone and misfolding pancreatic lipase variant cooperatively promote endoplasmic reticulum stress and cell death.

PLoS ONE, 2022
Mutation-induced protein misfolding of pancreatic secretory enzymes and consequent endoplasmic reticulum stress can cause chronic pancreatitis. A recent study revealed that cigarette smoke also increases the risk of the disease through endoplasmic ...
Norbert Kassay, Vanda Toldi, József Tőzsér, András Szabó   +3 more
doaj   +2 more sources

Endoplasmic Reticulum Stress and Cancer [PDF]

Journal of Cancer Prevention, 2014
The endoplasmic reticulum (ER) is the principal organelle responsible for multiple cellular functions including protein folding and maturation and the maintenance of cellular homeostasis. ER stress is activated by a variety of factors and triggers the unfolded protein response (UPR), which restores homeostasis or activates cell death.
Yadav, Raj Kumar, Chae, Soo-Wan, Kim, Hyung-Ryong, Chae, Han Jung   +3 more
openaire   +2 more sources

Stress-induced neuroprotective effects of epiregulin and amphiregulin. [PDF]

PLoS ONE, 2015
Members of the epidermal growth factor family play important roles in the regulation of cell growth, proliferation, and survival. However, the specific roles of each epidermal growth factor family member with respect to brain injury are not well ...
Libin Zhan, Luping Zheng, Toru Hosoi, Yasunobu Okuma, Yasuyuki Nomura   +4 more
doaj   +1 more source

Estrogens promote misfolded proinsulin degradation to protect insulin production and delay diabetes [PDF]

, 2018
Summary: Conjugated estrogens (CE) delay the onset of type 2 diabetes (T2D) in postmenopausal women, but the mechanism is unclear. In T2D, the endoplasmic reticulum (ER) fails to promote proinsulin folding and, in failing to do so, promotes ER stress and
Allard, Camille, Alvarez-Mercado, Ana I, Arvan, Peter, Coons, Laurel A, Floyd, Z. Elizabeth, Fuselier, Taylor, Hewitt, Sylvia C, Kim, Jun Ho, Korach, Kenneth S, Levin, Ellis R, Mauvais-Jarvis, Franck, Urano, Fumihiko, Xu, Beibei   +12 more
core   +2 more sources

Inhibition of endoplasmic reticulum stress alleviates secondary injury after traumatic brain injury

Neural Regeneration Research, 2018
Apoptosis after traumatic brain injury has been shown to be a major factor influencing prognosis and outcome. Endoplasmic reticulum stress may be involved in mitochondrial mediated neuronal apoptosis. Therefore, endoplasmic reticulum stress has become an
Hong-Ping Tan, Qiang Guo, Gang Hua, Jun-Xi Chen, Jun-Chao Liang   +4 more
doaj   +1 more source