Endoplasmic Reticulum Stress in Malignancy [PDF]
Cancer Cell, 2014 The combination of relative nutrient deprivation and dysregulation of protein synthesis make malignant cells especially prone to protein misfolding. Endoplasmic reticulum stress, which results from protein misfolding within the secretory pathway, has a profound effect on cancer cell proliferation and survival.
Clarke, Hanna J +3 more
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Research Progress on Endoplasmic Reticulum Stress-Mediated Apoptosis and Its Regulatory Mechanism on Muscle Tenderization [PDF]
Shipin KexueThe endoplasmic reticulum is a key site for calcium storage, lipid synthesis, protein synthesis, transport and folding, and it performs several critical biological functions.
LI Chenlong, LUO Yulong, DONG Yushan, DU Xuerong, YAO Lili, HOU Yanru, WANG Jiayu, XU Shengyun
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Regulated Inositol‐Requiring Protein 1‐Dependent Decay as a Mechanism of Corin RNA and Protein Deficiency in Advanced Human Systolic Heart Failure [PDF]
, 2014 BACKGROUND: The compensatory actions of the endogenous natriuretic peptide system require adequate processing of natriuretic peptide pro‐hormones into biologically active, carboxyl‐terminal fragments.
Barton, P +5 more
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KRE5 Suppression Induces Cell Wall Stress and Alternative ER Stress Response Required for Maintaining Cell Wall Integrity in Candida glabrata. [PDF]
PLoS ONE, 2016 The maintenance of cell wall integrity in fungi is required for normal cell growth, division, hyphae formation, and antifungal tolerance. We observed that endoplasmic reticulum stress regulated cell wall integrity in Candida glabrata, which possesses ...
Yutaka Tanaka +7 more
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RBM10 Regulates Embryonic Trophoblast Injury via Endoplasmic Reticulum Stress
Clinical and Experimental Obstetrics & Gynecology, 2022 Background: Previous studies shown that RNA binding motif proteins (RBM) participate in regulating various physiological processes such as cell autophagy, proliferation, and apoptosis, and are abnormally highly expressed in placental trophoblast cells ...
Xiao Chen +4 more
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Endoplasmic reticulum stress and angiogenesis [PDF]
Fiziolohichnyĭ zhurnal, 2013 The endoplasmic reticulum is a dynamic intracellular organelle with exquisite sensitivity to alterations in homeostasis, and provides stringent quality control systems to ensure that the only correctly folded proteins transit to the Golgi and unfolded or misfolded proteins are retained and ultimately degraded.
D O, Minchenko +8 more
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Frontiers in Endocrinology, 2022 Background and PurposeCalcific Aortic Valve Disease (CAVD) is a crucial component of degenerative valvular disease in old age and with the increasing prevalence of the aging population.
Yiming Tao +13 more
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Research progress of endoplasmic reticulum stress of hypoxic pulmonary hypertension [PDF]
Jichu yixue yu linchuang, 2023 Hypoxic pulmonary hypertension (HPH) is a serious complication caused by long-term hypoxia,which is characterized by persistent vasoconstriction and irreversible vascular remodeling.
LIU Xingxing, WANG Weiwei, YUAN Haoxin
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ENDOPLASMIC RETICULUM STRESS IN SEPSIS [PDF]
Shock, 2015 Sepsis is an enormous public health issue and the leading cause of death in critically ill patients in intensive care units. Overwhelming inflammation, characterized by cytokine storm, oxidative threats, and neutrophil sequestration, is an underlying component of sepsis-associated organ failure.
Mohammad Moshahid, Khan +2 more
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Atherosusceptible Shear Stress Activates Endoplasmic Reticulum Stress to Promote Endothelial Inflammation. [PDF]
, 2017 Atherosclerosis impacts arteries where disturbed blood flow renders the endothelium susceptible to inflammation. Cytokine activation of endothelial cells (EC) upregulates VCAM-1 receptors that target monocyte recruitment to atherosusceptible regions ...
Bailey, Keith A +3 more
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