Results 31 to 40 of about 356,983 (328)

TorsinA participates in endoplasmic reticulum-associated degradation [PDF]

, 2013
TorsinA is an \(AAA^+\) ATPase located within the lumen of the endoplasmic reticulum and nuclear envelope, with a mutant form causing early onset torsion dystonia (DYT1).
Armata, Ioanna A., Breakefield, Xandra Owens, Caldwell, Guy A., Caldwell, Kim A., Chen, Pan, Cho, JinAh, da Hora, Cintia Carla, Farley, Jonathan E., Klein, Christine, Lencer, Wayne I., Nery, Flávia C., Tagaya, Mitsuo, Tannous, Bakhos A., Wang, Qiuyan, Yaqub, Uzma, Ye, Yihong   +15 more
core   +1 more source

β-cell dysfunctional ERAD/ubiquitin/proteasome system in type 2 diabetes mediated by islet amyloid polypeptide-induced UCH-L1 deficiency. [PDF]

, 2010
ObjectiveThe islet in type 2 diabetes is characterized by β-cell apoptosis, β-cell endoplasmic reticulum stress, and islet amyloid deposits derived from islet amyloid polypeptide (IAPP).
Butler, Alexandra E, Butler, Peter C, Costes, Safia, Daval, Marie, Gurlo, Tatyana, Huang, Chang-jiang, Matveyenko, Aleksey V, Rizza, Robert A   +7 more
core   +2 more sources

Endoplasmic reticulum stress activates telomerase [PDF]

Aging Cell, 2013
SummaryTelomerase contributes to cell proliferation and survival through both telomere‐dependent and telomere‐independent mechanisms. In this report, we discovered that endoplasmic reticulum (ER) stress transiently activates the catalytic components of telomerase (TERT) expression in human cancer cell lines and murine primary neural cells. Importantly,
Zhou, Junzhi, Mao, Beibei, Zhou, Qi, Ding, Deqiang, Wang, Miao, Guo, Peng, Gao, Yuhao, Shay, Jerry W, Yuan, Zengqiang, Cong, Yu-Sheng   +9 more
openaire   +2 more sources

Endoplasmic reticulum stress and organoids [PDF]

Organoid, 2021
Organoids represent an advanced tool in cell biology and have redefined biomedical research. Organoids are ideal for studies of biological processes, pharmacological studies, and therapeutic research to imitate pathological processes and preserve genetic
Rashedul Alam, Mohammad Mamun Ur Rashid, Mohammad Fazlul Kabir, Hyung-Ryong Kim   +3 more
doaj   +1 more source

Regulation of podocyte survival and endoplasmic reticulum stress by fatty acids and its modification by Stearoyl-CoA desaturases and cyclic AMP [PDF]

, 2011
Podocyte apoptosis is a hallmark in the development and progression of diabetic nephropathy (DN). Several factors of the diabetic milieu are known to induce podocyte apoptosis. Currently, the role of free fatty acids (FFAs) for podocytopathy and podocyte
Sieber, Jonas
core   +1 more source

The endoplasmic reticulum in plant immunity and cell death [PDF]

, 2012
The endoplasmic reticulum (ER) is a highly dynamic organelle in eukaryotic cells and a major production site of proteins destined for vacuoles, the plasma membrane, or apoplast in plants.
Eichmann, Ruth, Schäfer, P. (Patrick)
core   +2 more sources

Endoplasmic Reticulum Stress Triggers Autophagy [PDF]

Journal of Biological Chemistry, 2006
Eukaryotic cells have evolved strategies to respond to stress conditions. For example, autophagy in yeast is primarily a response to the stress of nutrient limitation. Autophagy is a catabolic process for the degradation and recycling of cytosolic, long lived, or aggregated proteins and excess or defective organelles.
Tomohiro, Yorimitsu, Usha, Nair, Zhifen, Yang, Daniel J, Klionsky   +3 more
openaire   +2 more sources

Membrane-associated RING ubiquitin ligase RNF-121 and advancement of cancer [PDF]

Cellular, Molecular and Biomedical Reports
Exploration of E3 ubiquitin ligases as potential therapeutic targets has been ongoing for two to three decades. Various chemicals and drugs have been developed to either upregulate or inhibit the activity of E3 ligases, aiming to mitigate several ...
Somesh Roy
doaj   +1 more source

Identification and immunological characterization of endoplasmic reticulum stress-related molecular subtypes in bronchopulmonary dysplasia based on machine learning

Frontiers in Physiology, 2023
Introduction: Bronchopulmonary dysplasia (BPD) is a life-threatening lung illness that affects premature infants and has a high incidence and mortality.
Ziyu Tao, Yan Mao, Yifang Hu, Xinfang Tang, Jimei Wang, Ni Zeng, Yunlei Bao, Fei Luo, Chuyan Wu, Feng Jiang   +9 more
doaj   +1 more source

Russell-like bodies in plant seeds share common features with prolamin bodies and occur upon recombinant protein production [PDF]

, 2019
Although many recombinant proteins have been produced in seeds at high yields without adverse effects on the plant, endoplasmic reticulum (ER) stress and aberrant localization of endogenous or recombinant proteins have also been reported.
Arcalis, Elsa, Avesani, Linda, Bortesi, Luisa, De Meyer, Thomas, de meyer, thomas, Depicker, Anna, Hilscher, Julia, Ibl, Verena, Morandini, Francesca, Pezzotti, Mario, Pum, Dietmar, Rademacher, Thomas, Stoger, Eva, Vitale, Alessandro   +13 more
core   +2 more sources