Results 41 to 50 of about 356,983 (328)
Inhibition of IRE1α-mediated XBP1 mRNA cleavage by XBP1 reveals a novel regulatory process during the unfolded protein response [PDF]
, 2017 Background: The mammalian endoplasmic reticulum (ER) continuously adapts to the cellular secretory load by the activation of an unfolded protein response (UPR).
Bulleid, Neil J. +4 more
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Obesity and endoplasmic reticulum (ER) stresses [PDF]
Frontiers in Immunology, 2012 In obesity, the adipose cells behave as inflammatory source and result to low grade inflammation. This systemic inflammation along with oxidative stress is a silent killer and damages other vital organs also. High metabolic process, induced due to high nutritional intake, results to endoplasmic reticulum (ER) stress and mitochondrial stress.
Tripathi, Yamini B., Pandey, Vivek
openaire +3 more sources
Obesity Induces Hypothalamic Endoplasmic Reticulum Stress and Impairs Proopiomelanocortin (POMC) Post-translational Processing [PDF]
, 2013 It was shown previously that abnormal prohormone processing or inactive proconverting enzymes that are responsible for this processing cause profound obesity.
Cakir, Isin +6 more
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BMC Musculoskeletal Disorders, 2023 Background We aimed to establish an osteosarcoma prognosis prediction model based on a signature of endoplasmic reticulum stress-related genes. Methods Differentially expressed genes (DEGs) between osteosarcoma with and without metastasis from The Cancer
Yong Zhao +5 more
doaj +1 more source
Endoplasmic reticulum involvement in yeast cell death [PDF]
, 2012 Yeast cells undergo programed cell death (PCD) with characteristic markers associated with apoptosis in mammalian cells including chromatin breakage, nuclear fragmentation, reactive oxygen species generation, and metacaspase activation.
Austriaco, Nicanor
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Endoplasmic Reticulum Stress in Bone Metastases [PDF]
Frontiers in Oncology, 2020 Metastases-the spreading of cancer cells from primary tumors to distant organs, including bone-is often incurable and is the major cause of morbidity in cancer patients. Understanding how cancer cells acquire the ability to colonize to bone and become overt metastases is critical to identify new therapeutic targets and develop new therapies against ...
Longyong Xu +11 more
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Neural Regeneration Research, 2015 Cerebral ischemia triggers secondary ischemia/reperfusion injury and endoplasmic reticulum stress initiates cell apoptosis. However, the regulatory mechanism of the signaling pathway remains unclear.
Jian-wen Yang, Zhi-ping Hu
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Ferroptosis and endoplasmic reticulum stress in ischemic stroke
Neural Regeneration ResearchFerroptosis is a form of non-apoptotic programmed cell death, and its mechanisms mainly involve the accumulation of lipid peroxides, imbalance in the amino acid antioxidant system, and disordered iron metabolism.
Yina Li +6 more
doaj +1 more source
Neural Regeneration Research, 2016 Neuronal apoptosis is mediated by intrinsic and extrinsic signaling pathways such as the membrane-mediated, mitochondrial, and endoplasmic reticulum stress pathways.
Guo-zhu Sun +6 more
doaj +1 more source
Frontiers in Pharmacology, 2021 Thyroid hormone is essential for hippocampal redox environment and neuronal viability in adulthood, where its deficiency causes hypothyroidism related to oxidative and endoplasmic reticulum stresses in the hippocampus, resulting in neuronal death.
Vanessa Blas-Valdivia +5 more
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