Mechanistic insights into endosomal escape by sodium oleate-modified liposomes [PDF]
Beilstein Journal of NanotechnologyEndosomal entrapment significantly limits the efficacy of drug delivery systems. This study investigates sodium oleate-modified liposomes (SO-Lipo) as an innovative strategy to enhance endosomal escape and improve cytosolic delivery in 4T1 triple ...
Ebrahim Sadaqa +3 more
doaj +3 more sources
Endosomal escape: A bottleneck for LNP-mediated therapeutics. [PDF]
Proc Natl Acad Sci U S ALipid nanoparticles (LNPs) have recently emerged as a powerful and versatile clinically approved platform for nucleic acid delivery, specifically for mRNA vaccines. A major bottleneck in the field is the release of mRNA-LNPs from the endosomal pathways into the cytosol of cells where they can execute their encoded functions.
Chatterjee S, Kon E, Sharma P, Peer D.
europepmc +4 more sources
Endosomal Escape and Nuclear Localization: Critical Barriers for Therapeutic Nucleic Acids [PDF]
MoleculesTherapeutic nucleic acids (TNAs) including antisense oligonucleotides (ASOs) and small interfering RNA (siRNA) have emerged as promising treatment strategies for a wide variety of diseases, offering the potential to modulate gene expression with a high ...
Randall Allen, Toshifumi Yokota
doaj +3 more sources
Enhancing Targeted Drug Delivery through Cell‐Specific Endosomal Escape [PDF]
ChemMedChemAbstractEndosome is a major barrier in the intracellular delivery of drugs, especially for biologics, such as proteins, peptides, and nucleic acids. After being endocytosed, these cargos will be trapped inside the endosomal compartments and finally degraded in the lysosomes.
Pengwen Chen, Horacio Cabral
semanticscholar +4 more sources
Delivery of RNA Therapeutics: The Great Endosomal Escape! [PDF]
Nucleic Acid Ther, 2022 RNA therapeutics, including siRNAs, antisense oligonucleotides, and other oligonucleotides, have great potential to selectively treat a multitude of human diseases, from cancer to COVID to Parkinson's disease. RNA therapeutic activity is mechanistically driven by Watson-Crick base pairing to the target gene RNA without the requirement of prior ...
Dowdy SF, Setten RL, Cui XS, Jadhav SG.
europepmc +4 more sources
Elucidating the Impact of Payload Conjugation on the Cell-Penetrating Efficiency of the Endosomal Escape Peptide dfTAT: Implications for Future Designs for CPP-Based Delivery Systems. [PDF]
Bioconjug Chem, 2023 Cell-penetrating peptides (CPPs) are promising tools for the intracellular delivery of various biological payloads. However, the impact of payload conjugation on the cell-penetrating activity of CPPs is poorly understood.
Diaz J +5 more
europepmc +3 more sources
DNA-inspired nanomaterials for enhanced endosomal escape. [PDF]
Proc Natl Acad Sci U S A, 2021 To realize RNA interference (RNAi) therapeutics, it is necessary to deliver therapeutic RNAs (such as small interfering RNA or siRNA) into cell cytoplasm. A major challenge of RNAi therapeutics is the endosomal entrapment of the delivered siRNA. In this study, we developed a family of delivery vehicles called Janus base nanopieces (NPs).
Lee J, Sands I, Zhang W, Zhou L, Chen Y.
europepmc +4 more sources
Sodium oleate functionalized simvastatin liposomes: boosting endosomal escape and anticancer efficacy in triple negative breast cancer [PDF]
Research in Pharmaceutical SciencesBackground and purpose: Due to delivery obstacles, Simvastatin, a potential anticancer agent, faces clinical limitations. This study aimed to enhance simvastatin delivery and efficacy against triple-negative breast cancer (TNBC) by developing liposomes ...
Ebrahim Sadaqa +3 more
doaj +2 more sources
Globoside Is an Essential Intracellular Factor Required for Parvovirus B19 Endosomal Escape [PDF]
CellsHuman parvovirus B19 (B19V), like most parvoviruses, possesses phospholipase A2 (PLA2) activity, which is thought to mediate endosomal escape by membrane disruption.
Jan Bieri +5 more
doaj +2 more sources
Chloroquine and cytosolic galectins affect endosomal escape of antisense oligonucleotides after Stabilin-mediated endocytosis [PDF]
Molecular Therapy: Nucleic Acids, 2023 Non-DNA-binding Stabilin-2/HARE receptors expressed on liver sinusoidal endothelial cells specifically bind to and internalize several classes of phosphorothioate antisense oligonucleotides (PS-ASOs).
Ekta Pandey, Edward N. Harris
doaj +2 more sources