Assessing cellular internalization and endosomal escape abilities of novel BUFII-Graphene oxide nanobioconjugates [PDF]
Frontiers in Chemistry, 2022 Cell-penetrating agents based on functionalized nanoplatforms have emerged as a promising approach for developing more efficient and multifunctional delivery vehicles for treating various complex diseases that require reaching different intracellular ...
Julian Daniel Torres-Vanegas +6 more
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Glycosylated Triterpenoids as Endosomal Escape Enhancers in Targeted Tumor Therapies [PDF]
Biomedicines, 2017 Protein-based targeted toxins play an increasingly important role in targeted tumor therapies. In spite of their high intrinsic toxicity, their efficacy in animal models is low. A major reason for this is the limited entry of the toxin into the cytosol of the target cell, which is required to mediate the fatal effect.
Hendrik Fuchs +6 more
openalex +5 more sources
Design rules for efficient endosomal escape
bioRxiv, 2023 AbstractThe inefficient translocation of proteins across biological membranes limits their application as therapeutic compounds and research tools. In most cases, translocation involves two steps: uptake into the endocytic pathway and endosomal escape.
Madeline Zoltek +5 more
openaire +3 more sources
International Journal of Nanomedicine, 2018 Xi Yang,1,2,* Bo Fan,3,* Wei Gao,4,5,* Liping Li,2 Tingting Li,3 Jinghua Sun,2 Xiaoyang Peng,2 Xiaoyan Li,2 Zhenjun Wang,2 Binquan Wang,4,5 Ruiping Zhang,2 Jun Xie1 1Department of Biochemistry and Molecular Biology, Shanxi Medical University, Taiyuan ...
Yang X +11 more
doaj +1 more source
Enhancing endosomal escape of transduced proteins by photochemical internalisation. [PDF]
PLoS ONE, 2012 Induced internalisation of functional proteins into cultured cells has become an important aspect in a rising number of in vitro and in vivo assays. The endo-lysosomal entrapment of the transduced proteins remains the major problem in all transduction ...
Kevin Mellert +4 more
doaj +4 more sources
Endosomal escape in magnetic nanostructures: Recent advances and future perspectives
Materials Today AdvancesSeveral evolving therapies depend on the delivery of therapeutic cargo into the cytoplasm. Engineered magnetic nanoparticles (MNPs) have played a pivotal role in advancing and modernizing cancer theranostics, vaccination and gene therapies.
Shubhangi D. Shirsat +8 more
doaj +2 more sources
Development of a Cationic Polymeric Micellar Structure with Endosomal Escape Capability Enables Enhanced Intramuscular Transfection of mRNA-LNPs [PDF]
VaccinesBackground/Objectives: The endosomal escape of lipid nanoparticles (LNPs) is crucial for efficient mRNA-based therapeutics. Here, we present a cationic polymeric micelle (cPM) as a safe and potent co-delivery system with enhanced endosomal escape ...
Siyuan Deng +7 more
doaj +2 more sources
Lipid nanoparticle topology regulates endosomal escape and delivery of RNA to the cytoplasm. [PDF]
Proc Natl Acad Sci U S A, 2023 Zheng L, Bandara SR, Tan Z, Leal C.
europepmc +3 more sources
A Serum Resistant Polymer with Exceptional Endosomal Escape and mRNA Delivery Efficacy for CRISPR Gene Therapy. [PDF]
Adv Sci (Weinh)Lv J +8 more
europepmc +3 more sources
A cleavable peptide adapter augments the activity of targeted toxins in combination with the glycosidic endosomal escape enhancer SO1861 [PDF]
BMC BiotechnologyBackground Treatment with tumor-targeted toxins attempts to overcome the disadvantages of conventional cancer therapies by directing a drug’s cytotoxic effect specifically towards cancer cells.
Finn J. Schulze +5 more
doaj +2 more sources