Results 31 to 40 of about 47,261 (313)

Charge-guided masking of a membrane-destabilizing peptide enables efficient endosomal escape for targeted intracellular delivery of proteins [PDF]

Acta Pharmaceutica Sinica B
Intracellular delivery of biologicals such as peptides, proteins, and nucleic acids presents a great opportunity for innovative therapeutics. However, the endosome entrapment remains a major bottleneck in the intracellular delivery of biomacromolecules ...
Yan Zhao, Haolin Jiang, Hang Chen, Jiazhen Yu, Luyao Wang, Wen Zhou, Juanjuan Du   +6 more
doaj   +2 more sources

Distinct effects of endosomal escape and inhibition of endosomal trafficking on gene delivery via electrotransfection.

PLoS ONE, 2017
A recent theory suggests that endocytosis is involved in uptake and intracellular transport of electrotransfected plasmid DNA (pDNA). The goal of the current study was to understand if approaches used previously to improve endocytosis of gene delivery ...
Lisa D Cervia, Chun-Chi Chang, Liangli Wang, Fan Yuan   +3 more
doaj   +3 more sources

Design and screening of novel endosomal escape compounds that enhance functional delivery of oligonucleotides <i>in vitro</i>. [PDF]

Mol Ther Nucleic Acids
Estupiñán HY, Baladi T, Roudi S, Munson MJ, Bost J, Gustafsson O, Velásquez-Ramírez D, Bhatt DK, Hagey D, Hekman D, Andersson S, Andaloussi SE, Dahlén A.   +12 more
europepmc   +2 more sources

Globoside is an essential intracellular factor required for parvovirus B19 endosomal escape in erythroid progenitor cells [PDF]

Bieri J, Suter C, Caliaro O, Bartetzko S, Bircher C, Ros C.   +5 more
europepmc   +2 more sources

Endosomal Escape of Lipid Nanoparticles: A Perspective on the Literature Data. [PDF]

ACS Nano
Endosomal escape remains a critical bottleneck for the intracellular delivery of nucleic acids by lipid nanoparticles (LNPs), largely due to its low efficiency and poorly understood mechanism.
Pei D.
europepmc   +2 more sources

Engineering Gypsophila elegans hairy root cultures to produce endosomal escape-enhancing saponins. [PDF]

Plant Biotechnol J
Lacchini E, Qu T, Moses T, Volkov AN, Goossens A.   +4 more
europepmc   +3 more sources

Mechanism of pH-sensitive Amphiphilic Endosomal Escape of Ionizable Lipid Nanoparticles for Cytosolic Nucleic Acid Delivery. [PDF]

Pharm Res
Lipid nanoparticles (LNPs) are among the most successful classes of nonviral delivery systems for nucleic acid-based therapeutics in treating human diseases.
Lu ZR, Sun D.
europepmc   +2 more sources

Vapor nanobubble is the more reliable photothermal mechanism for inducing endosomal escape of siRNA without disturbing cell homeostasis [PDF]

, 2020
Strategies for controlled delivery of therapeutic siRNA into living cells are in high demand as endosomal escape remains the most prominent bottleneck at the intracellular level.
Barriga, Gerardo Garcia-Diaz, Braeckmans, Kevin, Brans, Toon, De Keulenaer, Sarah, De Rycke, Riet, De Smedt, Stefaan, De Vos, Winnok H., Fraire, Juan, Houthaeve, Gaëlle, Liu, Jing, Mestdagh, Pieter, Raemdonck, Koen, Raes, Laurens, Stremersch, Stephan, Van Nieuwerburgh, Filip, Vandesompele, Jo, Vermeulen, Lotte   +16 more
core   +3 more sources

Tannic Acid Lipid Nanoparticles can Deliver Messenger RNA Payloads and Improve their Endosomal Escape [PDF]

Advances in Therapy, 2023
Even though lipid nanoparticles (LNPs) can deliver messenger RNA (mRNA) payloads into cells, their efficiency is often limited by endosomal trapping which prevents RNA payloads from acting therapeutically.
Yutian Ma, Owen S. Fenton
openalex   +2 more sources

Breaking free: endocytosis and endosomal escape of extracellular vesicles. [PDF]

Extracell Vesicles Circ Nucl Acids, 2023
Extracellular vesicles (EVs) are natural micro-/nanoparticles that play an important role in intercellular communication. They are secreted by producer/donor cells and subsequent uptake by recipient/acceptor cells may result in phenotypic changes in ...
Ribovski L, Joshi B, Gao J, Zuhorn I.
europepmc   +2 more sources