Results 41 to 50 of about 47,261 (313)

Endosomal escape of RNA therapeutics: How do we solve this rate-limiting problem? [PDF]

RNA, 2023
With over 15 FDA approved drugs on the market and numerous ongoing clinical trials, RNA therapeutics, such as small interfering RNAs (siRNAs) and antisense oligonucleotides (ASOs), have shown great potential to treat human disease.
Dowdy SF.
europepmc   +2 more sources

Probing Endosomal Escape Using pHlexi Nanoparticles [PDF]

Macromolecular Bioscience, 2016
The effective escape of nanocarriers from endosomal compartments of the cell remains a major hurdle in nanomedicine. The endosomal escape of pH‐responsive, self‐assembled, dual component particles based on poly[2‐(diethylamino)ethyl methacrylate)(PDEAEMA) and poly(ethylene glycol)‐b‐poly[2‐(diethylamino)ethyl methacrylate) (PEG‐b‐PDEAEMA) has been ...
Kongkatigumjorn, N, Cortez-Jugo, C, Czuba, E, Wong, ASM, Hodgetts, RY, Johnston, APR, Such, GK   +6 more
openaire   +3 more sources

A high-throughput Galectin-9 imaging assay for quantifying nanoparticle uptake, endosomal escape and functional RNA delivery

Communications Biology, 2021
Munson et al. develop a high-throughput Galectin-9 reporter based endosomal escape imaging assay to probe correlations between nanoparticle-mediated uptake, endosomal escape frequency, and mRNA translation.
Michael J. Munson, Gwen O’Driscoll, Andreia M. Silva, Elisa Lázaro-Ibáñez, Audrey Gallud, John T. Wilson, Anna Collén, Elin K. Esbjörner, Alan Sabirsh   +8 more
doaj   +1 more source

Endosomal escape mechanisms of extracellular vesicle-based drug carriers: lessons for lipid nanoparticle design. [PDF]

Extracell Vesicles Circ Nucl Acids
The rise of biologics and RNA-based therapies challenges the limitations of traditional drug treatments. However, these potent new classes of therapeutics require effective delivery systems to reach their full potential.
Hagedorn L, Jürgens DC, Merkel OM, Winkeljann B.   +3 more
europepmc   +2 more sources

Accelerated Endosomal Escape of Splice-Switching Oligonucleotides Enables Efficient Hepatic Splice Correction. [PDF]

ACS Appl Mater Interfaces
Weiss S, Decker S, Kugler C, Gómez LB, Fasching H, Benisch D, Alioglu F, Ferencz L, Birkfeld T, Ilievski F, Baumann V, Duran A, Dusinovic E, Follrich N, Milenkovic S, Mihalicokova D, Paunov D, Singeorzan K, Zehetmayer N, Zivanonvic D, Lächelt U, Boersma A, Rülicke T, Sami H, Ogris M.   +24 more
europepmc   +2 more sources

The targeted delivery of multicomponent cargos to cancer cells by nanoporous particle-supported lipid bilayers. [PDF]

, 2011
Encapsulation of drugs within nanocarriers that selectively target malignant cells promises to mitigate side effects of conventional chemotherapy and to enable delivery of the unique drug combinations needed for personalized medicine.
Ashley, Carlee E, Brinker, C Jeffrey, Brown, Page A, Carnes, Eric C, Carroll, Nick J, Carter, Mark B, Chackerian, Bryce, Dunphy, Darren R, Durfee, Paul N, Evans, Deborah G, Hanna, Tracey N, Jiang, Xingmao, Liu, Juewen, Padilla, David, Parikh, Atul N, Peabody, David S, Petsev, Dimiter N, Phillips, Brandy, Phillips, Genevieve K, Wharton, Walker, Willman, Cheryl L   +20 more
core   +10 more sources

Photoinduced Endosomal Escape Mechanism: A View from Photochemical Internalization Mediated by CPP-Photosensitizer Conjugates

Molecules, 2020
Endosomal escape in cell-penetrating peptide (CPP)-based drug/macromolecule delivery systems is frequently insufficient. The CPP-fused molecules tend to remain trapped inside endosomes and end up being degraded rather than delivered into the cytosol. One
Tet Htut Soe, Kazunori Watanabe, Takashi Ohtsuki   +2 more
doaj   +1 more source

Novel endosomolytic compounds enable highly potent delivery of antisense oligonucleotides

Communications Biology, 2022
Two new endosomolytic small compounds increase delivery of splice-switching oligonucleotides by interfering with their trafficking to the LAMP1-positive endosomal compartments, inducing endosomal membrane rupture and concurrent oligonucleotide escape ...
Jeremy P. Bost, Miina Ojansivu, Michael J. Munson, Emelie Wesén, Audrey Gallud, Dhanu Gupta, Oskar Gustafsson, Osama Saher, Julia Rädler, Stuart G. Higgins, Taavi Lehto, Margaret N. Holme, Anders Dahlén, Ola Engkvist, Per-Erik Strömstedt, Shalini Andersson, C. I. Edvard Smith, Molly M. Stevens, Elin K. Esbjörner, Anna Collén, Samir El Andaloussi   +20 more
doaj   +1 more source

Listeria InlB Expedites Vacuole Escape and Intracellular Proliferation by Promoting Rab7 Recruitment via Vps34

mBio, 2023
Rapid phagosomal escape mediated by listeriolysin O (LLO) is a prerequisite for Listeria monocytogenes intracellular replication and pathogenesis. Escape takes place within minutes after internalization from vacuoles that are negative to the early ...
Robert J. Cain, Mariela Scortti, Héctor J. Monzó, José A. Vázquez-Boland   +3 more
doaj   +1 more source

An Endosomal Escape Trojan Horse Platform to Improve Cytosolic Delivery of Nucleic Acids. [PDF]

ACS Nano
Endocytosis is a major bottleneck toward cytosolic delivery of nucleic acids, as the vast majority of nucleic acid drugs remain trapped within endosomes.
Narum S, Deal B, Ogasawara H, Mancuso JN, Zhang J, Salaita K.   +5 more
europepmc   +2 more sources