Results 1 to 10 of about 143,231 (141)

A novel live-cell imaging assay reveals regulation of endosome maturation

eLife, 2021
Cell-cell communication is an essential process in life, with endosomes acting as key organelles for regulating uptake and secretion of signaling molecules.
Maria Podinovskaia, Cristina Prescianotto-Baschong, Dominik P Buser, Anne Spang   +3 more
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Interaction between PI3K and the VDAC2 channel tethers Ras-PI3K-positive endosomes to mitochondria and promotes endosome maturation

Cell Reports, 2023
Summary: Intracellular organelles of mammalian cells communicate with one another during various cellular processes. The functions and molecular mechanisms of such interorganelle association remain largely unclear, however.
Aya O. Satoh, Yoichiro Fujioka, Sayaka Kashiwagi, Aiko Yoshida, Mari Fujioka, Hitoshi Sasajima, Asuka Nanbo, Maho Amano, Yusuke Ohba   +8 more
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Acid-labile chemical bonds-based nanoparticles for endosome escape and intracellular delivery

Biomedical Technology, 2023
In the last years there has been a booming in the development of biological pharmaceuticals, and various nanoparticle delivery systems have been developed to overcome biological barriers to maximize the therapeutic potentials. Especially, when these drug-
Ruoyu Cheng, Shiqi Wang, Hélder A. Santos   +2 more
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Fission of tubular endosomes triggers endosomal acidification and movement. [PDF]

PLoS ONE, 2011
The early endosome acts as a sorting station for internalized molecules destined for recycling or degradation. While recycled molecules are sorted and delivered to tubular endosomes, residual compartments containing molecules to be degraded undergo ...
Kumi Mesaki, Kenji Tanabe, Masanori Obayashi, Natsuko Oe, Kohji Takei   +4 more
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Lipid Transfer–Dependent Endosome Maturation Mediated by Protrudin and PDZD8 in Neurons

Frontiers in Cell and Developmental Biology, 2020
Endosome maturation refers to the conversion of early endosomes (EEs) to late endosomes (LEs) for subsequent fusion with lysosomes. It is an incremental process that involves a combination of endosome fusion and fission and which occurs at contact sites ...
Michiko Shirane
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Regulation of Endosomal Sorting and Maturation by ER-Endosome Contact Sites

Contact, 2022
Endosomes are a heterogeneous population of intracellular organelles responsible for sorting, recycling, or transporting internalized materials for degradation.
Steve Jean, Sonya Nassari
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Synaptic Vesicle Recycling and the Endolysosomal System: A Reappraisal of Form and Function

Frontiers in Synaptic Neuroscience, 2022
The endolysosomal system is present in all cell types. Within these cells, it performs a series of essential roles, such as trafficking and sorting of membrane cargo, intracellular signaling, control of metabolism and degradation.
Daniela Ivanova, Daniela Ivanova, Daniela Ivanova, Michael A. Cousin, Michael A. Cousin, Michael A. Cousin   +5 more
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p120 catenin recruits HPV to γ-secretase to promote virus infection.

PLoS Pathogens, 2020
During internalization and trafficking, human papillomavirus (HPV) moves from the cell surface to the endosome where the transmembrane protease γ-secretase promotes insertion of the viral L2 capsid protein into the endosome membrane.
Mara Calypso Harwood, Allison Jade Dupzyk, Takamasa Inoue, Daniel DiMaio, Billy Tsai   +4 more
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Hepatitis B virus promotes its own replication by enhancing RAB5A-mediated dual activation of endosomal and autophagic vesicle pathways

Emerging Microbes and Infections, 2023
Chronic hepatitis B virus (HBV) infection remains one of the major global public health concerns, and it develop into liver fibrosis, cirrhosis, and hepatocellular carcinoma.
Zhenyu Zhao, Zhen Wei, Jiaxin Zheng, Zhihong Li, Hecun Zou, Xiang Wen, Fahong Li, Xueyu Wang, Qian Huang, Huaqing Zeng, Hui Fan, Xuefei Cai, Jiming Zhang, Bei Jia, Ailong Huang, Mengji Lu, Yong Lin   +16 more
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An appressorium membrane protein, Pams1, controls infection structure maturation and virulence via maintaining endosomal stability in the rice blast fungus

Frontiers in Plant Science, 2022
The rice blast fungus Magnaporthe oryzae spores differentiate and mature into functional appressoria by sensing the host surface signals. Environmental stimuli are transduced into cells through internalization during appressorium formation, such as in ...
Jing Wang, Qing Wang, Pengyun Huang, Yingmin Qu, Zhicheng Huang, Huan Wang, Xiao-Hong Liu, Fu-Cheng Lin, Fu-Cheng Lin, Jianping Lu   +9 more
doaj   +1 more source