Results 1 to 10 of about 144,395 (141)

A novel live-cell imaging assay reveals regulation of endosome maturation

eLife, 2021
Cell-cell communication is an essential process in life, with endosomes acting as key organelles for regulating uptake and secretion of signaling molecules.
Maria Podinovskaia, Cristina Prescianotto-Baschong, Dominik P Buser, Anne Spang   +3 more
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Interaction between PI3K and the VDAC2 channel tethers Ras-PI3K-positive endosomes to mitochondria and promotes endosome maturation

Cell Reports, 2023
Summary: Intracellular organelles of mammalian cells communicate with one another during various cellular processes. The functions and molecular mechanisms of such interorganelle association remain largely unclear, however.
Aya O. Satoh, Yoichiro Fujioka, Sayaka Kashiwagi, Aiko Yoshida, Mari Fujioka, Hitoshi Sasajima, Asuka Nanbo, Maho Amano, Yusuke Ohba   +8 more
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Acid-labile chemical bonds-based nanoparticles for endosome escape and intracellular delivery

Biomedical Technology, 2023
In the last years there has been a booming in the development of biological pharmaceuticals, and various nanoparticle delivery systems have been developed to overcome biological barriers to maximize the therapeutic potentials. Especially, when these drug-
Ruoyu Cheng, Shiqi Wang, Hélder A. Santos   +2 more
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Fission of tubular endosomes triggers endosomal acidification and movement. [PDF]

PLoS ONE, 2011
The early endosome acts as a sorting station for internalized molecules destined for recycling or degradation. While recycled molecules are sorted and delivered to tubular endosomes, residual compartments containing molecules to be degraded undergo ...
Kumi Mesaki, Kenji Tanabe, Masanori Obayashi, Natsuko Oe, Kohji Takei   +4 more
doaj   +1 more source

Therapeutic Targeting of Endosome and Mitochondrial Reactive Oxygen Species Protects Mice From Influenza Virus Morbidity

Frontiers in Pharmacology, 2022
There is an urgent need to develop effective therapeutic strategies including immunomodulators to combat influenza A virus (IAV) infection. Influenza A viruses increase ROS production, which suppress anti-viral responses and contribute to pathological ...
Eunice E. To, Eunice E. To, Jonathan R. Erlich, Felicia Liong, Stella Liong, Raymond Luong, Osezua Oseghale, Mark A. Miles, Paris C. Papagianis, Kylie M. Quinn, Steven Bozinovski, Ross Vlahos, Robert D. Brooks, John J. O’Leary, John J. O’Leary, Doug A. Brooks, Doug A. Brooks, Stavros Selemidis   +17 more
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Capping protein regulates endosomal trafficking by controlling F-actin density around endocytic vesicles and recruiting RAB5 effectors

eLife, 2021
Actin filaments (F-actin) have been implicated in various steps of endosomal trafficking, and the length of F-actin is controlled by actin capping proteins, such as CapZ, which is a stable heterodimeric protein complex consisting of α and β subunits ...
Dawei Wang, Zuodong Ye, Wenjie Wei, Jingting Yu, Lihong Huang, Hongmin Zhang, Jianbo Yue   +6 more
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Lipid Transfer–Dependent Endosome Maturation Mediated by Protrudin and PDZD8 in Neurons

Frontiers in Cell and Developmental Biology, 2020
Endosome maturation refers to the conversion of early endosomes (EEs) to late endosomes (LEs) for subsequent fusion with lysosomes. It is an incremental process that involves a combination of endosome fusion and fission and which occurs at contact sites ...
Michiko Shirane
doaj   +1 more source

Regulation of Endosomal Sorting and Maturation by ER-Endosome Contact Sites

Contact, 2022
Endosomes are a heterogeneous population of intracellular organelles responsible for sorting, recycling, or transporting internalized materials for degradation.
Steve Jean, Sonya Nassari
doaj   +1 more source

Compartmentalization of Melanin Biosynthetic Enzymes Contributes to Self-Defense against Intermediate Compound Scytalone in Botrytis cinerea

mBio, 2021
In filamentous fungi, 1,8-dihydroxynaphthalene (DHN) melanin is a major component of the extracellular matrix, endowing fungi with environmental tolerance and some pathogenic species with pathogenicity.
Xue Chen, Chuanxi Zhu, Yantao Na, Dandan Ren, Chenghua Zhang, Yifan He, Yiwen Wang, Sheng Xiang, Weiheng Ren, Yina Jiang, Ling Xu, Pinkuan Zhu   +11 more
doaj   +1 more source

A PX-BAR protein Mvp1/SNX8 and a dynamin-like GTPase Vps1 drive endosomal recycling

eLife, 2021
Membrane protein recycling systems are essential for maintenance of the endosome-lysosome system. In yeast, retromer and Snx4 coat complexes are recruited to the endosomal surface, where they recognize cargos. They sort cargo and deform the membrane into
Sho W Suzuki, Akihiko Oishi, Nadia Nikulin, Jeff R Jorgensen, Matthew G Baile, Scott D Emr   +5 more
doaj   +1 more source