eLife, 2023 Although budding yeast has been extensively used as a model organism for studying organelle functions and intracellular vesicle trafficking, whether it possesses an independent endocytic early/sorting compartment that sorts endocytic cargos to the endo ...
Junko Y Toshima +6 more
doaj +1 more source
Real-time visualization of clustering and intracellular transport of gold nanoparticles by correlative imaging. [PDF]
, 2017 Mechanistic understanding of the endocytosis and intracellular trafficking of nanoparticles is essential for designing smart theranostic carriers. Physico-chemical properties, including size, clustering and surface chemistry of nanoparticles regulate ...
Chen, Nan +13 more
core +2 more sources
Early endosomes and endosomal coatomer are required for autophagy [PDF]
Journal of Cell Biology, 2009 Autophagy, an intracellular degradative pathway, maintains cell homeostasis under normal and stress conditions. Nascent double-membrane autophagosomes sequester and enclose cytosolic components and organelles, and subsequently fuse with the endosomal pathway allowing content degradation.
Razi, M. +2 more
openaire +4 more sources
Gene transfer into hepatocytes using asialoglycoprotein receptor mediated endocytosis of DNA complexed with an artificial tetra-antennary galactose ligand [PDF]
, 1992 We have constructed an artificial ligand for the hepatocyte-specific asialoglycoprotein receptor for the purpose of generating a synthetic delivery system for DNA.
Ashwell G. +36 more
core +1 more source
Canine respiratory coronavirus employs caveolin-1-mediated pathway for internalization to HRT-18G cells [PDF]
, 2018 Canine respiratory coronavirus (CRCoV), identified in 2003, is a member of the Coronaviridae family. The virus is a betacoronavirus and a close relative of human coronavirus OC43 and bovine coronavirus.
A Milewska +75 more
core +8 more sources
Many Keys Unlock the Doors for Virus Entry
mBio, 2022 To successfully infect, viruses must respond to cues that promote their genome delivery into host cells. These keys to virus entry frequently reside inside endocytic vesicles. In a recent mBio article, Poston et al. (D. Poston, Y. Weisblum, A. Hobbs, and
Tom Gallagher
doaj +1 more source
Delivery of ligands from sorting endosomes to late endosomes occurs by maturation of sorting endosomes [PDF]
The Journal of cell biology, 1992 After endocytosis, lysosomally targeted ligands pass through a series of endosomal compartments. The endocytic apparatus that accomplishes this passage may be considered to take one of two forms: (a) a system in which lysosomally targeted ligands pass through preexisting, long-lived early sorting endosomes and are then selectively transported to long ...
K W, Dunn, F R, Maxfield
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Neurobiology of Disease, 2014 Dementia with Lewy bodies (DLB), Parkinson’s disease (PD) and multiple system atrophy are characterized by the deposition of disease-associated α-synuclein.
Gabor G. Kovacs +14 more
doaj +1 more source
A conserved and regulated mechanism drives endosomal Rab transition
eLife, 2020 Endosomes and lysosomes harbor Rab5 and Rab7 on their surface as key proteins involved in their identity, biogenesis, and fusion. Rab activation requires a guanine nucleotide exchange factor (GEF), which is Mon1-Ccz1 for Rab7. During endosome maturation,
Lars Langemeyer +8 more
doaj +1 more source
Quantification of Protein Uptake by Endocytosis in Carnivorous Nepenthales
Plants, 2023 Carnivorous plants adsorb prey-derived nutrients partly by endocytosis. This study quantifies endocytosis in Drosophyllum lusitanicum, Drosera capensis, Drosera roseana, Dionaea muscipula and Nepenthes × ventrata.
Caroline Ivesic +7 more
doaj +1 more source