Results 1 to 10 of about 187,332 (400)

Endocytosis of Extracellular Vesicles and Release of Their Cargo from Endosomes

ACS Nano, 2020
Extracellular vesicles (EVs), such as exosomes, can mediate long-distance communication between cells by delivering biomolecular cargo. It is speculated that EVs undergo back-fusion at multivesicular bodies (MVBs) in recipient cells to release their ...
Bhagyashree S Joshi, Marit A De Beer, Ben N G Giepmans   +2 more
exaly   +2 more sources

Recycling endosomes. [PDF]

Current Opinion in Cell Biology, 2015
The endosomal membrane recycling system represents a dynamic conduit for sorting and re-exporting internalized membrane constituents. The recycling system is composed of multiple tubulovesicular recycling pathways that likely confer distinct trafficking pathways for individual cargoes.
J. Goldenring
semanticscholar   +3 more sources

Super-resolution Imaging of Proton Sponge-Triggered Rupture of Endosomes and Cytosolic Release of Small Interfering RNA

ACS Nano, 2019
The intracellular delivery of nucleic acids and proteins remains a key challenge in the development of biological therapeutics. In gene therapy, the inefficient delivery of small interfering RNA (siRNA) to the cytosol by lipoplexes or polyplexes is often
Marcin Wojnilowicz, Agata Glab, Frank Caruso   +2 more
exaly   +2 more sources

Clathrin regenerates synaptic vesicles from endosomes

Nature, 2014
Ultrafast endocytosis can retrieve a single, large endocytic vesicle as fast as 50–100 ms after synaptic vesicle fusion. However, the fate of the large endocytic vesicles is not known.
Shigeki Watanabe, Thorsten Trimbuch, Benjamin R Rost   +2 more
exaly   +2 more sources

The neuropathy-linked protein TECPR2 is a Rab5 effector that regulates cargo recycling from early endosomes. [PDF]

Nat Commun
Paul S, Pant R, Sharma P, Walia K, Gupta S, Aseem A, Bajwa KK, George R, Varma Y, Bhatia T, Ramachandran R, Tuli A, Sharma M.   +12 more
europepmc   +2 more sources

A pH-responsive nanoparticle targets the neurokinin 1 receptor in endosomes to prevent chronic pain

Nature Nanotechnology, 2019
Paulina D Ramírez-García, Jeffri S Retamal, Priyank Shenoy   +2 more
exaly   +2 more sources

A phosphoinositide conversion mechanism for exit from endosomes

Nature, 2016
Anne-Sophie Nicot, Dmytro Puchkov, Carsten Schultz   +2 more
exaly   +2 more sources

Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief

Science Translational Medicine, 2017
Dane D Jensen, TinaMarie Lieu, Michelle L Halls   +2 more
exaly   +2 more sources

Conformational biosensors reveal GPCR signalling from endosomes

Nature, 2013
Roshanak Irannejad, Jan Steyaert, Roger K Sunahara   +2 more
exaly   +2 more sources

A promising RNA nanotechnology in clinical therapeutics: a future perspective narrative review

Future Science OA, 2023
Nanotechnology is the use of materials that have unique nanoscale properties. In recent years, nanotechnologies have shown promising results for human health, especially in cancer treatment. The self-assembly characteristic of RNA is a powerful bottom-up
Mahmoud M Tolba, Abdul Jabbar, Sadia Afzal, Mohammed Mahmoud, Farheen Zulfiqar, Ingy El-Soudany, Salma Samir, Al-Hassan Soliman Wadan, Takwa E Ellakwa, Doha El-Sayed Ellakwa   +9 more
doaj   +1 more source