Results 21 to 30 of about 187,332 (400)

The Coordination of Local Translation, Membranous Organelle Trafficking, and Synaptic Plasticity in Neurons

Frontiers in Cell and Developmental Biology, 2021
Neurons are highly complex polarized cells, displaying an extraordinary degree of spatial compartmentalization. At presynaptic and postsynaptic sites, far from the cell body, local protein synthesis is utilized to continually modify the synaptic proteome,
Dipen Rajgor, Theresa M. Welle, Katharine R. Smith   +2 more
doaj   +1 more source

Fibronectin rescues estrogen receptor α from lysosomal degradation in breast cancer cells [PDF]

, 2018
Estrogen receptor α (ERα) is expressed in tissues as diverse as brains and mammary glands. In breast cancer, ERα is a key regulator of tumor progression.
Acconcia, Acconcia, Acerbi, Adlanmerini, Alfredo Cáceres, Ambrose, Andrés M. Toscani, Arjonen, Arnal, Axelrod, Axelrod, Bacia, Bae, Barabas, Bates, Bermudez-Hernandez, Bonifacino, Bradford, Cancer Genome Atlas Network, Caswell, Cerami, Chaumet, Chung, Ciriello, Ciriello, Correia, Cosker, Cosker, Couse, Cox, Dante R. Chialvo, De Franceschi, Debnath, Degasperi, Delcroix, Dozynkiewicz, Dunn, Eirew, Federico Coluccio Leskow, Fernando D. Stefani, Gao, Gao, Ghajar, Gillespie, Gould, Graham, Grant, Han, Han, Hartley, He, Heery, Helleman, Hernández, Hines, Honerkamp-Smith, Ianina L. Violi, Jeselsohn, Johnson, Jonathon N. Lakins, Kate Thi, Kisler, La Rosa, Letoha, Levin, Li, Long, Lu, Lu, Luciano A. Masullo, Luzio, Mak, Marina Simian, Marino, Matthew G. Rubashkin, Mayor, Mayor, Małecki, McDonough, Mina J. Bissell, Moreno-Layseca, Nam, Nardone, Nicovich, Ovesný, Pedram, Pereira, Pietras, Pontiggia, Razandi, Reid, Rocío G. Sampayo, Rust, Savkur, Schindelin, Schlegel, Skliris, Solowska, Su, Sung, Takahashi, Tiwari, Totta, Totta, Upla, Valerie M. Weaver, van de Linde, Vanlandingham, Wang, Waxmonsky, William C. Hines, Yao   +111 more
core   +2 more sources

Guiding Endosomal Maturation [PDF]

Cell, 2010
In the endocytic pathway, early endosomes are converted into late endosomes by exchange of their associated Rab GTPases. In this issue, Poteryaev et al. (2010) identify the SAND-1/Mon1 protein as a switch that shuts off the recruitment of one Rab (Rab5) and facilitates the activation of the next (Rab7).
Cabrera, Margarita, Ungermann, Christian
openaire   +2 more sources

Ongoing activation of sphingosine 1-phosphate receptors mediates maturation of exosomal multivesicular endosomes

Nature Communications, 2013
Taketoshi Kajimoto, Taro Okada, Shun-Ichi Nakamura   +2 more
exaly   +2 more sources

Participation of Endosomes in Toll-Like Receptor 3 Transportation Pathway in Murine Astrocytes

Frontiers in Cellular Neuroscience, 2020
TLR3 provides immediate type I IFN response following entry of stimulatory PAMPs into the CNS, as it is in HSV infection. The receptor plays a vital role in astrocytes, contributing to rapid infection sensing and suppression of viral replication ...
Matylda B. Mielcarska, Karolina P. Gregorczyk-Zboroch, Lidia Szulc-Dąbrowska, Magdalena Bossowska-Nowicka, Zbigniew Wyżewski, Joanna Cymerys, Marcin Chodkowski, Paula Kiełbik, Michał M. Godlewski, Małgorzata Gieryńska, Felix N. Toka, Felix N. Toka   +11 more
doaj   +1 more source

From the cell membrane to the nucleus: unearthing transport mechanisms for Dynein [PDF]

, 2012
Mutations in the motor protein cytoplasmic dynein have been found to cause Charcot-Marie-Tooth disease, spinal muscular atrophy, and severe intellectual disabilities in humans. In mouse models, neurodegeneration is observed.
A. Friedman, A. G. Hendricks, A. G. Hendricks, A. J. Roberts, A. Kunwar, A. P. Carter, A. V. Kuznetsov, A. V. Kuznetsov, Anotida Madzvamuse, C. Korn, C. L. Brown, Caroline A. Garrett, D. A. Smith, D. Tsygankov, E. Bananis, J. L. Ross, J. Munárriz, J. W. Driver, J. W. Murray, J. W. Wojcieszyn, K. Imamula, K. M. Ori-McKenney, K. S. Zadeh, L. W. Duchen, Laurie Crossley, M. A. Gee, M. B. Harms, M. Bier, M. H. Willemsen, M. Hafezparast, M. N. Weedon, M. Schliwa, M. Schuster, M. Schuster, Majid Hafezparast, O. J. Driskell, P. Ashwin, R. D. Vale, S. A. Burgess, S. Ally, S. C. Schaffner, S. Hoepfner, S. Lubery, S. Mitragotri, S. Mukherji, T. D. Pollard, T. Kon, V. Soppina, W. Deng, X. J. Chen, Y. Gao, Y. Imafuku, Y. Zhang, Y. Zhang   +53 more
core   +1 more source

Contaminating transfection complexes can masquerade as small extracellular vesicles and impair their delivery of RNA

Journal of Extracellular Vesicles, 2022
One of the functions of small extracellular vesicles (sEVs) which has received the most attention is their capacity to deliver RNA into the cytoplasm of target cells.
Jenna McCann, Carmen Daniela Sosa‐Miranda, Huishan Guo, Ryan Reshke, Alexandre Savard, Adriana Zardini Buzatto, James A. Taylor, Liang Li, Derrick J. Gibbings   +8 more
doaj   +1 more source

Rab2 drives axonal transport of dense core vesicles and lysosomal organelles

Cell Reports, 2021
Summary: Fast axonal transport of neuropeptide-containing dense core vesicles (DCVs), endolysosomal organelles, and presynaptic components is critical for maintaining neuronal functionality.
Viktor Karlovich Lund, Matthew Domenic Lycas, Anders Schack, Rita Chan Andersen, Ulrik Gether, Ole Kjaerulff   +5 more
doaj   +1 more source

Clostridium perfringens epsilon toxin induces blood brain barrier permeability via caveolae-dependent transcytosis and requires expression of MAL. [PDF]

, 2019
Clostridium perfringens epsilon toxin (ETX) is responsible for causing the economically devastating disease, enterotoxaemia, in livestock. It is well accepted that ETX causes blood brain barrier (BBB) permeability, however the mechanisms involved in this
Dobrow, Sebastian, Flores, Claudia, Linden, Jennifer R, Michel, Adam O, Schmidt, Eric F, Uzal, Francisco A, Valenzuela, Marissa, Vartanian, Timothy   +7 more
core   +1 more source

WASH and Tsg101/ALIX-dependent diversion of stress-internalized EGFR from the canonical endocytic pathway [PDF]

, 2015
Stress exposure triggers ligand-independent EGF receptor (EGFR) endocytosis, but its post-endocytic fate and role in regulating signalling are unclear. We show that the p38 MAP kinase-dependent, EGFR tyrosine kinase (TK)-independent EGFR internalization ...
Burgoyne, T, Futter, CE, Hartley, JA, Hochhauser, D, Sorkin, A, Tomas, A, Vaughan, SO   +6 more
core   +1 more source