Auxin Signaling in Regulation of Plant Translation Reinitiation
Frontiers in Plant Science, 2017 The mRNA translation machinery directs protein production, and thus cell growth, according to prevailing cellular and environmental conditions. The target of rapamycin (TOR) signaling pathway—a major growth-related pathway—plays a pivotal role in ...
Mikhail Schepetilnikov +1 more
doaj +1 more source
Early endosomes and endosomal coatomer are required for autophagy [PDF]
Journal of Cell Biology, 2009 Autophagy, an intracellular degradative pathway, maintains cell homeostasis under normal and stress conditions. Nascent double-membrane autophagosomes sequester and enclose cytosolic components and organelles, and subsequently fuse with the endosomal pathway allowing content degradation.
Razi, M. +2 more
openaire +4 more sources
Dynamics of lysosomal cholesterol in Niemann-Pick type C and normal human fibroblasts
Journal of Lipid Research, 2002 The dynamics of endolysosomal cholesterol were investigated in Niemann-Pick type C (NPC) cells and in human fibroblasts treated with class 2 amphiphiles to mimic NPC cells.
Yvonne Lange +3 more
doaj +1 more source
Changes in membrane lipids drive increased endocytosis following Fas ligation [PDF]
, 2017 Once activated, some surface receptors promote membrane movements that open new portals of endocytosis, in part to facilitate the internalization of their activated complexes.
Degli Esposti, Mauro +9 more
core +1 more source
Mutation of SLC35D3 causes metabolic syndrome by impairing dopamine signaling in striatal D1 neurons [PDF]
, 2014 We thank Dr. Ya-Qin Feng from Shanxi Medical University, Dr. Tian-Yun Gao from Nanjing University and Dr. Yan-Hong Xue from Institute of Biophysics (CAS) for technical assistance in this study. We are very thankful to Drs. Richard T. Swank and Xiao-Jiang
Gao, Xiang +13 more
core +3 more sources
Fusion of Enveloped Viruses in Endosomes
Traffic : the International Journal of Intracellular Transport, 2016 Ari Helenius launched the field of enveloped virus fusion in endosomes with a seminal paper in the Journal of Cell Biology in 1980. In the intervening years, a great deal has been learned about the structures and mechanisms of viral membrane fusion ...
J. White, G. Whittaker
semanticscholar +1 more source
Targeting of early endosomes by autophagy facilitates EGFR recycling and signalling
EMBO Reports, 2019 Despite recently uncovered connections between autophagy and the endocytic pathway, the role of autophagy in regulating endosomal function remains incompletely understood.
Jane Fraser +5 more
semanticscholar +1 more source
Current Knowledge of Endolysosomal and Autophagy Defects in Hereditary Spastic Paraplegia
Cells, 2021 Hereditary spastic paraplegia (HSP) refers to a group of neurological disorders involving the degeneration of motor neurons. Due to their clinical and genetic heterogeneity, finding common effective therapeutics is difficult.
Liriopé Toupenet Marchesi +2 more
doaj +1 more source
Poly(2-propylacrylic acid)/poly(lactic-co-glycolic acid) blend microparticles as a targeted antigen delivery system to direct either CD4+ or CD8+ T cell activation. [PDF]
, 2017 Poly(lactic-co-glycolic acid) (PLGA) based microparticles (MPs) are widely investigated for their ability to load a range of molecules with high efficiency, including antigenic proteins, and release them in a controlled manner.
Bracho-Sanchez, Evelyn +6 more
core +1 more source
Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance Activated G protein-coupled receptors (GPCRs) internalize and can continue to signal from endosomes. The contribution of endosomal signaling to human disease is unknown.
N. Jimenez-Vargas +26 more
semanticscholar +1 more source