Results 61 to 70 of about 187,332 (400)

Regulation of the formation and water permeability of endosomes from toad bladder granular cells. [PDF]

, 1990
Osmotic water permeability (Pf) in toad bladder is regulated by the vasopressin (VP)-dependent movement of vesicles containing water channels between the cytoplasm and apical membrane of granular cells.
Shi, LB, Verkman, AS, Wang, YX
core  

Ubiquitin-dependent endocytosis of NKG2D-DAP10 receptor complexes activates signaling and functions in human NK cells [PDF]

, 2015
Cytotoxic lymphocytes share the presence of the activating receptor NK receptor group 2, member D (NKG2D) and the signaling-competent adaptor DNAX-activating protein 10 (DAP10), which together play an important role in antitumor immune surveillance ...
CAPUANO, CRISTINA, CIPPITELLI, Marco, FIONDA, Cinzia, GALANDRINI, Ricciarda, MOLFETTA, Rosa, PAOLINI, Rossella, PERUZZI, Giovanna, QUATRINI, LINDA, SANTONI, Angela, ZITTI, BEATRICE   +9 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Distribution and trafficking of MPR300 is normal in cells with cholesterol accumulated in late endocytic compartments

Journal of Lipid Research, 2003
It has been reported that an accumulation of cholesterol within late endosomes/lysosomes in Niemann-Pick type C (NPC) fibroblasts and U18666A-treated cells causes impairment of retrograde trafficking of the cation-independent mannose 6-phosphate/IGF-II ...
Atsushi Umeda, Hideaki Fujita, Toshio Kuronita, Kaori Hirosako, Masaru Himeno, Yoshitaka Tanaka   +5 more
doaj   +1 more source

Nbr1 Is a Novel Inhibitor of Ligand-Mediated Receptor Tyrosine Kinase Degradation [PDF]

, 2010
endocytic trafficking and selective autophagy. However, the exact function of Nbr1 in these contexts has not been studied in detail. Here we investigated the role of Nbr1 in the trafficking of receptor tyrosine kinases (RTKs).
Auciello, Giulio, Dafforn, Tim R., Heath, John K, Mardakheh, Faraz K., Rappoport, Joshua Z.   +4 more
core   +2 more sources

Selective Enrichment of Tetraspan Proteins on the Internal Vesicles of Multivesicular Endosomes and on Exosomes Secreted by Human B-lymphocytes*

Journal of Biological Chemistry, 1998
Association of major histocompatibility complex (MHC) class II molecules with peptides occurs in a series of endocytic vacuoles, termed MHC class II-enriched compartments (MIICs).
J. Escola, M. Kleijmeer, W. Stoorvogel, Janice M. Griffith, O. Yoshie, H. Geuze   +5 more
semanticscholar   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

The deleted in brachydactyly B domain of ROR2 is required for receptor activation by recruitment of Src [PDF]

, 2007
The transmembrane receptor 'ROR2' resembles members of the receptor tyrosine kinase family of signalling receptors in sequence but its' signal transduction mechanisms remain enigmatic.
A Schambony, AJ Mikels, AR Afzal, Faraz Khosravi Mardakheh, GC Schwabe, H Hikasa, H van Bokhoven, I Oishi, I Oishi, J Billiard, J Liu, John K. Heath, JP Gorvel, K Alexandropoulos, Lee M. Wheldon, M Miaczynska, M Nishita, M Oldridge, M Sammar, MR Larsen, P Masiakowski, R Ishizawar, Richard Steinhardt, S Stricker, S Takeuchi, SA Beausoleil, Shiva Akbarzadeh, Sonia Talma, Steve M. M. Sweet, TM DeChiara, WC Forrester, Y Liu, Z Songyang   +32 more
core   +5 more sources

The phospholipid flippase ATP9A is required for the recycling pathway from the endosomes to the plasma membrane

Molecular Biology of the Cell, 2016
ATP9A is localized to phosphatidylserine-positive early and recycling endosomes, but not late endosomes, in HeLa cells. ATP9A plays a crucial role in recycling of transferrin and glucose transporter 1 from endosomes to the plasma membrane.
Yoshiki Tanaka, Natsuki Ono, Takahiro Shima, Gaku Tanaka, Yohei Katoh, K. Nakayama, H. Takatsu, Hye-Won Shin   +7 more
semanticscholar   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source