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Endothelial Dysfunction in Hypertension
Journal of Cardiovascular Pharmacology, 2001Endothelium can deeply influence vascular tone and structure. The main endothelium derived factor is nitric oxide, which is not only a potent vasodilator but also inhibits platelet aggregation, smooth muscle cell migration and proliferation, monocyte adhesion and adhesion molecule expression, thus protecting the vessel wall against the development of ...
TADDEI, STEFANO +4 more
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Endothelial Cell Signaling and Endothelial Dysfunction
American Journal of Hypertension, 1995Endothelial cells have an important protective role in maintaining the normal physiologic function of the vascular wall. When these cells become dysfunctional, they lose this protective influence and they actively promote pathophysiological changes within the blood vessel. This review will discuss some of the extracellular signaling mechanisms employed
Flavahan, NA, Vanhoutte, PM
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Endothelial dysfunction in hypertension.
Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 1997link_to_subscribed_fulltext
TADDEI, STEFANO, SALVETTI, ANTONIO
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Endothelial dysfunction in glaucoma
Acta Ophthalmologica, 2009Abstract.Glaucoma is a group of ocular diseases characterized by optic neuropathy associated with loss of the retinal nerve fibre layer and re‐modelling of the optic nerve head, and a subsequent particular pattern of visual field loss. Increased intraocular pressure is the most important risk factor for the disease, but the pathogenesis of glaucoma is ...
Hemma, Resch +4 more
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Endothelial Dysfunction and Stroke
Journal of Cardiovascular Pharmacology, 2001Endothelial dysfunction, intended as the complex multifaced pathological product of different vasculotoxic agents or injuries, is viewed today as an attractant intermediate phenotype of cardiovascular diseases with usually long and unpredictable natural history.
COSENTINO, Francesco +5 more
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Hypercholesterolemia and endothelial dysfunction
Current Opinion in Lipidology, 1995Endothelial cells respond to hemodynamic forces with the expression of different phenotypes with disparate functional properties. At arterial bends and flow dividers, cells are relatively deprived of fluid-shear-stress-induced cell differentiation and exhibit phenotypes with increased mitotic rate, decreased intercellular contact, increased ...
P D, Henry, O A, Cabello, C H, Chen
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Assessment of endothelial dysfunction
Expert Review of Cardiovascular Therapy, 2010The pathophysiology underlying the initiation and progression of cardiovascular disorders is highly complex and multifactorial. The endothelium also plays a crucial role in the pathogenesis of thrombogenesis and atherogenesis, and a continuum of endothelial activation, dysfunction or damage is evident in many cardiovascular disorders both at the macro ...
Bethan, Freestone +2 more
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Vascular endothelial dysfunction
Progress in Cardiovascular Diseases, 1997Injury or activation of the endothelium changes its regulatory functions and results in abnormal endothelial cell function. Dysfunction of the endothelium has been defined as an imbalance between relaxing and contracting factors, between procoagulant and anticoagulant mediators or between growth-inhibiting and growth-promoting substances.
De Meyer, Guido, Herman, Arnold
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2015
The hypothesis that preeclampsia phenotypes result from endothelial cell dysfunction has been followed by decades of evidence demonstrating vascular dysfunction and augmented vascular reactivity in preeclampsia. Multiple studies have detected biomarkers of endothelial activation prior to overt disease.
Davidge, Sandra T. +2 more
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The hypothesis that preeclampsia phenotypes result from endothelial cell dysfunction has been followed by decades of evidence demonstrating vascular dysfunction and augmented vascular reactivity in preeclampsia. Multiple studies have detected biomarkers of endothelial activation prior to overt disease.
Davidge, Sandra T. +2 more
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Endothelial dysfunction in hypertension
Acta Cardiologica, 2000Endothelial cells release both relaxing and contracting factors that modulate vascular smooth muscle tone and also participate in the pathophysiology of essential hypertension. Endothelium-dependent vasodilation is regulated primarily by nitric oxide but also by an unidentified endothelium-derived hyperpolarizing factor and by prostacyclin. Endothelium-
P, Puddu +3 more
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