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Statins and Endothelial Dysfunction
Seminars in Vascular Medicine, 2004The endothelium integrates and modulates critical functions of the arterial wall. As well as regulating vasomotion, it controls inflammation, coagulation, and thrombosis. Many of these actions are mediated through the release of nitric oxide. Endothelial dysfunction is associated with atherosclerosis and its risk factors. It is independently correlated
Eric, Larose, Peter, Ganz
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Mitochondrial dysfunction in the pathogenesis of endothelial dysfunction
Molecular and Cellular Biochemistry, 2023Cardiovascular diseases (CVDs) are a matter of concern worldwide, and mitochondrial dysfunction is one of the major contributing factors. Vascular endothelial dysfunction has a major role in the development of atherosclerosis because of the abnormal chemokine secretion, inflammatory mediators, enhancement of LDL oxidation, cytokine elevation, and ...
Suresh Kumar, Prajapat +2 more
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Endothelial Dysfunction and Hypertension
2016In the past, endothelium was thought to be only a mechanical barrier. Today, endothelium is known to be a tissue regulating vascular tone, cell growth and the interaction between the leukocytes, thrombocytes and the vessel wall. It also synthesizes growth factors and thrombo-regulatory molecules and responds to physical and chemical signals.
Konukoglu, Dildar, Uzun, Hafize
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Endothelial Dysfunction in Atherosclerosis
Journal of Vascular Research, 1996Endothelial injury or dysfunction has been proposed to be one of the initiating events of atherosclerosis and is associated with an apparent decrease in the production of the vasodilator autacoid nitric oxide (NO). The nature of the endothelial dysfunction resulting in an attenuation of NO-mediated responses is unknown although possibilities include ...
R, Busse, I, Fleming
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Smoking and Endothelial Dysfunction
Current Vascular Pharmacology, 2019Cigarette smoking is one of the most important health concerns worldwide. Even though the rate of smoking is declining in developed countries, it is still experiencing growth in developing regions. Many studies have examined the relationship between smoking, as an established risk factor, and cardiovascular diseases. We provide an updated review of the
Golbidi, Saeid +2 more
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Endothelial Dysfunction in Sepsis
Current Vascular Pharmacology, 2013The endothelium takes part in the regulation of numerous physiological functions and lies at the interface of circulating blood and the vessel wall. Under physiological conditions, it is responsible for anticoagulant and anti-adhesive properties, and it regulates vasomotor tone and vascular homeostasis.
Julie, Boisramé-Helms +3 more
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Endothelial Dysfunction and Hypertension
Drugs, 1997Vascular endothelial cells play a key role in cardiovascular regulation by producing a number of potent vasoactive agents, including the vasodilator molecule nitric oxide (NO) and the vasoconstrictor peptide endothelin (ET)-1. A dysfunction of the vascular endothelium has been implicated in the pathophysiology of a number of cardiovascular diseases ...
C J, Ferro, D J, Webb
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Endothelial Dysfunction and Atherosclerosis
Journal of Cardiac Surgery, 1989There is increasing evidence that the vascular endothelium is an important functional component of the blood vessel wall, actively participating in normal vascular physiology as well as the pathogenesis of vascular diseases such as atherosclerosis.
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Markers of Endothelial Dysfunction
cclm, 2000AbstractThe endothelium is a functional barrier between vessel wall and blood stream. Assuming the total human vascular and capillary system occupies a surface area of more than 1,000 m2which is covered by 1013endothelial cells, the complex role of the endothelium for hemostasis and immunological and metabolic processes becomes obvious.
M M, Müller, A, Griesmacher
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Obesity and Endothelial Dysfunction
Seminars in Vascular Medicine, 2005Obesity is becoming more prevalent in the developed world because of the abundance of food and the decrease of physical activity. Obesity is a risk factor for a host of diseases from arthritis to cardiovascular disease. The precise mechanisms by which obesity promotes cardiovascular disease are not well understood but are likely to include metabolic ...
Sudha S, Shankar, Helmut O, Steinberg
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