Results 91 to 100 of about 27,105 (199)

Endothelial glycocalyx damage as a systemic inflammatory microvascular endotheliopathy in COVID-19

open access: yesBiomedical Journal, 2020
In atherosclerosis patients, vascular endothelial dysfunction is commonly observed alongside damage of the vascular endothelial glycocalyx, an extracellular matrix bound to and encapsulating the endothelial cells lining the blood vessel wall.
Minako Yamaoka-Tojo
doaj   +1 more source

Fasting as Medicine: Mitochondrial and Endothelial Rejuvenation in Vascular Aging

open access: yesAging Cell, Volume 25, Issue 2, February 2026.
Aging impairs cerebrovascular health by driving mitochondrial dysfunction, oxidative stress, endothelial failure, and neurovascular uncoupling, leading to BBB breakdown and cognitive decline. In contrast, time‐restricted feeding/eating counteracts these mechanisms by restoring mitochondrial function, activating adaptive nutrient‐sensing pathways ...
Madison Milan   +13 more
wiley   +1 more source

Near wall hemodynamics: Modelling the glycocalyx and the endothelial surface [PDF]

open access: yes, 2011
This paper was presented at the 3rd Micro and Nano Flows Conference (MNF2011), which was held at the Makedonia Palace Hotel, Thessaloniki in Greece.
3rd Micro and Nano Flows Conference (MNF2011)   +6 more
core  

Concurrent coupling of atomistic simulation and mesoscopic hydrodynamics for flows over soft multi-functional surfaces

open access: yes, 2018
We develop an efficient parallel multiscale method that bridges the atomistic and mesoscale regimes, from nanometer to micron and beyond, via concurrent coupling of atomistic simulation and mesoscopic dynamics.
Karniadakis, George Em   +4 more
core   +1 more source

Charge effects on the hindered transport of macromolecules across the endothelial surface glycocalyx layer [PDF]

open access: yes, 2012
A fluid mechanical and electrostatic model for the transport of solute molecules across the vascular endothelial surface glycocalyx layer (EGL) was developed to study the charge effect on the diffusive and convective transport of the solutes.
Akinaga Takeshi   +5 more
core   +2 more sources

Diagnostic Performance of Prothrombin Time and Activated Partial Thromboplastin Time in Children: A Service Evaluation

open access: yesInternational Journal of Laboratory Hematology, Volume 48, Issue 1, Page 188-193, February 2026.
ABSTRACT Background Coagulation screening, consisting of prothrombin time (PT) and activated partial prothrombin time (aPTT), is routinely performed in paediatrics to identify bleeding disorders or guide peri‐procedural management. We evaluated the trends in utilisation and diagnostic yield of PT and aPTT testing as part of coagulation screening in a ...
Gerard Gurumurthy   +4 more
wiley   +1 more source

Macromolecular approaches to prevent thrombosis and intimal hyperplasia following percutaneous coronary intervention. [PDF]

open access: yes, 2014
Cardiovascular disease remains one of the largest contributors to death worldwide. Improvements in cardiovascular technology leading to the current generation of drug-eluting stents, bioresorbable stents, and drug-eluting balloons, coupled with advances ...
Panitch, Alyssa, Scott, Rebecca A
core   +2 more sources

Engineering Complexity: Advances in 3D Breast Cancer Models for Precision Oncology

open access: yesAdvanced Healthcare Materials, Volume 15, Issue 1, 9 January 2026.
In vitro breast cancer models that closely mimic the complex biological and cellular interactions within the tumor microenvironment hold strong promise for enhancing our understanding of tumor progression, immune system behavior, and resistance to therapies, which are essential for developing personalized cancer treatments. Abstract Engineered in vitro
Wonwoo Jeong, Sang Jin Lee
wiley   +1 more source

Endothelial CXCR2 deficiency attenuates renal inflammation and glycocalyx shedding through NF-κB signaling in diabetic kidney disease

open access: yesCell Communication and Signaling
Background The incidence of diabetic kidney disease (DKD) continues to rapidly increase, with limited available treatment options. One of the hallmarks of DKD is persistent inflammation, but the underlying molecular mechanisms of early diabetic kidney ...
Siyuan Cui   +6 more
doaj   +1 more source

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