Balance of Mechanical Forces Drives Endothelial Gap Formation and May Facilitate Cancer and Immune-Cell Extravasation [PDF]
, 2018 The formation of gaps in the endothelium is a crucial process underlying both cancer and immune cell extravasation, contributing to the functioning of the immune system during infection, the unfavorable development of chronic inflammation and tumor metastasis.
arxiv +1 more source
Global existence and weak-strong uniqueness for chemotaxis compressible Navier-Stokes equations modeling vascular network formation [PDF]
arXiv, 2023 A model of vascular network formation is analyzed in a bounded domain, consisting of the compressible Navier-Stokes equations for the density of the endothelial cells and their velocity, coupled to a reaction-diffusion equation for the concentration of the chemoattractant, which triggers the migration of the endothelial cells and the blood vessel ...
arxiv
Computational Screening of Tip and Stalk Cell Behavior Proposes a Role for Apelin Signaling in Sprout Progression [PDF]
PLoS ONE 11(11): e0159478 (2016), 2014 Angiogenesis involves the formation of new blood vessels by sprouting or splitting of existing blood vessels. During sprouting, a highly motile type of endothelial cell, called the tip cell, migrates from the blood vessels followed by stalk cells, an endothelial cell type that forms the body of the sprout.
arxiv +1 more source
Enhanced Integrin α4β1-Mediated Adhesion Contributes to a Mobilization Defect of Endothelial Progenitor Cells in Diabetes. [PDF]
, 2016 Diabetes is associated with a deficit of circulating endothelial progenitor cells (EPCs), which has been attributed to their defective mobilization from the bone marrow.
Abplanalp, Wesley T +6 more
core +2 more sources
Advanced Functional Materials, EarlyView.In this work, melt electrowriting is used to fabricate a 3D printed scaffold design that generates engineered cardiac tissues with in‐plane contraction, mimicking natural myocardium. It is shown that these tissues display advanced maturation and functionality.
Olalla Iglesias‐García +23 more
wiley +1 more source
Unjamming and nematic flocks in endothelial monolayers during angiogenesis : theoretical and experimental analysis [PDF]
, 2018 Angiogenesis is the complex process by which new blood vessels develop from an existing vasculature in order to supply nutrients and/or metabolites to tissues, playing a fundamental role in many physiological and pathological conditions such as embryogenesis and tissue repair or tumour growth.
arxiv +1 more source
Molecular Dynamics Simulation of Vascular Network Formation [PDF]
Journal of Statistical Mechanics: Theory and Experiments (2009)
P05013, 10 pages, 2007 Endothelial cells are responsible for the formation of the capillary blood vessel network. We describe a system of endothelial cells by means of two-dimensional molecular dynamics simulations of point-like particles. Cells' motion is governed by the gradient of the concentration of a chemical substance that they produce (chemotaxis).
arxiv +1 more source
Milieu-adopted in vitro and in vivo differentiation of mesenchymal tissues derived from different adult human CD34-negative progenitor cell clones [PDF]
, 2005 Adult mesenchymal stem cells with multilineage differentiation potentially exist in the bone marrow, but have also been isolated from the peripheral blood.
Huss, R. +4 more
core +1 more source
Electric Pulse Regulated MXene Based Nanozymes for Integrative Bioelectricity Immuno‐Cancer Therapy
Advanced Functional Materials, EarlyView.MXenzyme‐mediated bioelectricity cancer therapy (MXenzyme‐BECT) enhances cancer cell death through irreversible depolarization, ion channel disruption, ROS generation, and immunogenic cell death. Computational simulations reveal the electrical mechanisms by which MXenzyme acts on single cells and support to predict treatment parameters. Next‐generation
Sanghee Lee +6 more
wiley +1 more source
The effect of shear stress reduction on endothelial cells: a microfluidic study of the actin cytoskeleton [PDF]
arXiv, 2020 Reduced blood flow, as occurring in ischemia or resulting from exposure to microgravity such as encountered in space flights, induces a decrease in the level of shear stress sensed by the endothelial cells forming the inner part of blood vessels. In the present study, we use a microvasculature-on-a-chip device in order to investigate in vitro the ...
arxiv