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The aging endothelium [PDF]

open access: yesVascular Biology, 2021
Cellular senescence is now recognized as one of the hallmarks of aging. Herein, we examine current findings on senescence of the vascular endothelium and its impacts on age-related vascular diseases.
Ka Ka Ting   +4 more
doaj   +3 more sources

The Endothelium in Sepsis [PDF]

open access: yesShock, 2016
Sepsis affects practically all aspects of endothelial cell (EC) function and is thought to be the key factor in the progression from sepsis to organ failure. Endothelial functions affected by sepsis include vasoregulation, barrier function, inflammation, and hemostasis.
Ince, Can   +8 more
openaire   +8 more sources

Transient heart rate reduction improves acute decompensated heart failure‐induced left ventricular and coronary dysfunction

open access: yesESC Heart Failure, 2021
Aims Acute decompensated heart failure (ADHF), a live‐threatening complication of heart failure (HF), associates a further decrease of the already by HF‐impaired cardiac function with an increase in heart rate.
Nicolas Peschanski   +15 more
doaj   +1 more source

Comparative study of the effects of cigarette smoke versus next generation tobacco and nicotine product extracts on endothelial function

open access: yesRedox Biology, 2021
Tobacco smoking and hemodynamic forces are key stimuli for the development of endothelial dysfunction. As an alternative to smoking, next generation tobacco and nicotine products (NGP) are now widely used.
Sindy Giebe   +6 more
doaj   +1 more source

The Endothelium in Acromegaly [PDF]

open access: yesFrontiers in Endocrinology, 2019
Growth hormone (GH) and insulin like growth factor-1 (IGF-1) excess induce well-known deleterious effects on the cardiovascular system, especially after long-term exposition. Acromegaly, a condition of chronic GH and IGF-1 hypersecretion, is frequently associated to cardiovascular complications, although recent studies have shown a reduction in the ...
Maffei, Pietro   +4 more
openaire   +4 more sources

Effects of PCSK9 Targeting: Alleviating Oxidation, Inflammation, and Atherosclerosis

open access: yesJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Characterized as a chronic inflammatory disease of the large arteries, atherosclerosis is the primary cause of cardiovascular disease, the leading contributor of morbidity and mortality worldwide.
Emily Punch   +4 more
doaj   +1 more source

Differentiating Arteriolosclerotic Ulcers of Martorell from Other Types of Leg Ulcers Based on Vascular Histomorphology

open access: yesActa Dermato-Venereologica, 2021
Clinical differential diagnosis of arteriolosclerotic ulcers of Martorell is challenging due to the lack of clearly affirmative instrument-based diagnostic criteria.
Julia Deinsberger   +11 more
doaj   +1 more source

The artificial endothelium [PDF]

open access: yesOrganogenesis, 2011
As the world of critical care medicine advances, extracorporeal therapies (ECC) have become commonplace in the management of the high risk intensive care patient. ECC encompasses a wide variety of technologies from hemodialysis, continuous renal replacement therapy (CRRT) and plasmapheresis, to cardiopulmonary bypass (CPB), extracorporeal life support (
Melissa M. Reynolds, Gail M. Annich
openaire   +3 more sources

YAP and the RhoC regulator ARHGAP18, are required to mediate flow-dependent endothelial cell alignment

open access: yesCell Communication and Signaling, 2020
Background Vascular endothelial cell alignment in the direction of flow is an adaptive response that protects against aortic diseases such as atherosclerosis. The RhoGTPases are known to regulate this alignment.
Paul R. Coleman   +7 more
doaj   +1 more source

Reproducibility and research integrity: the role of scientists and institutions

open access: yesBMC Research Notes, 2021
Reproducibility and research integrity are essential tenets of every scientific study and discovery. They serve as proof that an established and documented work can be verified, repeated, and reproduced.
Patrick Diaba-Nuhoho   +1 more
doaj   +1 more source

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