Results 11 to 20 of about 519,199 (308)

iEnhancer-EBLSTM: Identifying Enhancers and Strengths by Ensembles of Bidirectional Long Short-Term Memory

Frontiers in Genetics, 2021
Enhancers are regulatory DNA sequences that could be bound by specific proteins named transcription factors (TFs). The interactions between enhancers and TFs regulate specific genes by increasing the target gene expression.
Kun Niu, Ximei Luo, Shumei Zhang, Zhixia Teng, Tianjiao Zhang, Yuming Zhao   +5 more
doaj   +1 more source

Comprehensive landscape of epigenetic-dysregulated lncRNAs reveals a profound role of enhancers in carcinogenesis in BC subtypes

Molecular Therapy: Nucleic Acids, 2021
Aberrant expression of long non-coding RNAs (lncRNA) is associated with altered DNA methylation and histone modifications during carcinogenesis. However, identifying epigenetically dysregulated lncRNAs and characterizing their functional mechanisms in ...
Hongying Zhao, Xiaoqin Liu, Lei Yu, Shihua Lin, Caiyu Zhang, Haotian Xu, Zhijun Leng, Waidong Huang, Junjie Lei, Tengyue Li, Jing Li, Fan Yang, Li Wang   +12 more
doaj   +1 more source

Establishment of regions of genomic activity during the Drosophila maternal to zygotic transition

eLife, 2014
We describe the genome-wide distributions and temporal dynamics of nucleosomes and post-translational histone modifications throughout the maternal-to-zygotic transition in embryos of Drosophila melanogaster.
Xiao-Yong Li, Melissa M Harrison, Jacqueline E Villalta, Tommy Kaplan, Michael B Eisen   +4 more
doaj   +1 more source

Switch Tandem Repeats Influence the Choice of the Alternative End-Joining Pathway in Immunoglobulin Class Switch Recombination

Frontiers in Immunology, 2022
Immunoglobulin class switch recombination (CSR) plays an important role in humoral imm\une responses by changing the effector functions of antibodies. CSR occurs between highly repetitive switch (S) sequences located upstream of immunoglobulin constant ...
Chloé Oudinet, Xuefei Zhang, Nadine Puget, Nia Kyritsis, Claire Leduc, Fatima-Zohra Braikia, Audrey Dauba, Frederick W. Alt, Ahmed Amine Khamlichi   +8 more
doaj   +1 more source

The strong enhancer element in the immediate early region of the human cytomegalovirus genome [PDF]

, 1985
The human cytomegalovirus (HCMV), a member of the herpesvirus group, was found to possess a strong transcription enhancer in the immediate early gene region. Co-transfection of enhancerless SV40 DNA with randomly fragmented HCMV DNA yielded two SV40-
Boshart, Michael, Calendar, R., Dorsch-Häsler, Karoline, Fleckenstein, Bernhard, Gold, L., Jahn, Gerhard, Rüger, Rüdiger, Schaffner, Walter, Stoerker, Jay, Weber, Frank   +9 more
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LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development. [PDF]

, 2020
Developmental progression depends on temporally defined changes in gene expression mediated by transient exposure of lineage intermediates to signals in the progenitor niche.
Benner, Christopher W, Geusz, Ryan J, Harrington, Austin R, Jhala, Ulupi S, Matta, Ileana, Patel, Nisha A, Rosenfeld, Michael G, Sander, Maike, Shih, Hung-Ping, Vinckier, Nicholas K, Wang, Allen, Wang, Jianxun, Wang, Jinzhao, Wetton, Nichole, Wortham, Matthew   +14 more
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Enhancers [PDF]

WIREs Developmental Biology, 2012
AbstractTranscription of eukaryotic genes is an exceedingly sophisticated and complicated process, orchestrated by layers of control mechanisms involving a myriad of transcription factors and DNA control sequences, with both groups subject to multiple modifications.
openaire   +2 more sources

Discovery and validation of sub-threshold genome-wide association study loci using epigenomic signatures

eLife, 2016
Genetic variants identified by genome-wide association studies explain only a modest proportion of heritability, suggesting that meaningful associations lie 'hidden' below current thresholds.
Xinchen Wang, Nathan R Tucker, Gizem Rizki, Robert Mills, Peter HL Krijger, Elzo de Wit, Vidya Subramanian, Eric Bartell, Xinh-Xinh Nguyen, Jiangchuan Ye, Jordan Leyton-Mange, Elena V Dolmatova, Pim van der Harst, Wouter de Laat, Patrick T Ellinor, Christopher Newton-Cheh, David J Milan, Manolis Kellis, Laurie A Boyer   +18 more
doaj   +1 more source

Tumour suppressor TET2 safeguards enhancers from aberrant DNA methylation and epigenetic reprogramming in ERα-positive breast cancer cells

Epigenetics, 2022
Aberrant DNA methylation is an epigenetic hallmark of malignant tumours. The DNA methylation level is regulated by not only DNA methyltransferases (DNMTs) but also Ten-Eleven Translocation (TET) family proteins.
Ruitu Lyu, Xuguo Zhu, Yinghui Shen, Lijun Xiong, Lu Liu, Hang Liu, Feizhen Wu, Christian Argueta, Li Tan   +8 more
doaj   +1 more source

HoxA9 binds and represses the Cebpa +8 kb enhancer [PDF]

, 2019
C/EBPα plays a key role in specifying myeloid lineage development. HoxA9 is expressed in myeloid progenitors, with its level diminishing during myeloid maturation, and HOXA9 is over-expressed in a majority of acute myeloid leukemia cases, including those
Aplan, Peter D., Dennison, Lauren, Friedman, Alan D., Guo, Hong, Hess, Jay L., Ma, Peilin, Peng, Lei, Sun, Yuqing   +7 more
core   +2 more sources