Effects of Cholinergic and Opioid Antagonists on In Vitro Release of Met-Enkephalin, Somatostatin and Insulin-like Growth Factor-1 by and PENK Expression in Crop, Proventriculus and Duodenum of Newly Hatched Chickens [PDF]
AnimalsThe gastrointestinal (GI) tract is under neural, endocrine and paracrine control. The release (basal and in the presence of either cholinergic and opioid antagonists) of Met-enkephalin, insulin-like growth factor 1 (IGF-1) and somatostatin (SRIF) was ...
Colin G. Scanes +3 more
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Research note: Peripheral administration of Met-enkephalin: Novel attenuation of the adrenal medullary and thyroidal stress responses in young female chickens [PDF]
Poultry ScienceAdrenal hormones play a critical response to stresses in poultry, livestock and other vertebrates. Moreover, there are stress effects on thyroid hormones. Plasma concentrations of epinephrine (EP), norepinephrine (NE), thyroxine (T4) and triiodothyronine
Colin G. Scanes +1 more
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Highly sensitive in vivo detection of dynamic changes in enkephalins following acute stress in mice [PDF]
eLifeEnkephalins are opioid peptides that modulate analgesia, reward, and stress. In vivo detection of enkephalins remains difficult due to transient and low endogenous concentrations and inherent sequence similarity.
Marwa O Mikati +8 more
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Disparate Effects of Stressors on Met-Enkephalin System Parameters and on Plasma Concentrations of Corticosterone in Young Female Chickens [PDF]
AnimalsThe effects of stressors were examined on Met-enkephalin-related parameters and plasma concentrations of corticosterone in 14-week-old female chickens.
Colin Guy Scanes +1 more
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Co‐Expression of Tardive Dyskinesia and Drug‐Induced Parkinsonism in Rats Chronically Treated With Haloperidol [PDF]
Neuropsychopharmacology ReportsAim We aimed to create a rat model of drug‐induced parkinsonism and tardive dyskinesia by chronic administration of haloperidol and examine the expression of direct and indirect pathway markers in the striatum of the model rats.
Iku Kinoshita +7 more
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Role of enkephalin derivative in promoting wound healing and scar remodeling via increased epidermal growth factor in a mouse model [PDF]
Archives of Aesthetic Plastic Surgery, 2023 Background Enkephalin, an endogenous neuropeptide, binds to the delta (δ) opioid receptor and exerts an antinociceptive effect. Recent studies have suggested that neuropeptides might effectuate cutaneous wound healing.
Sun Eung Kim +2 more
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The role of enkephalinergic systems in substance use disorders
Frontiers in Systems Neuroscience, 2022 Enkephalin, an endogenous opioid peptide, is highly expressed in the reward pathway and may modulate neurotransmission to regulate reward-related behaviors, such as drug-taking and drug-seeking behaviors.
Lauren G. Rysztak +2 more
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A drug delivery strategy: binding enkephalin to asialoglycoprotein receptor by enzymatic galactosylation. [PDF]
PLoS ONE, 2014 Glycosylation of biopharmaceuticals can mediate cell specific delivery by targeting carbohydrate receptors. Additionally, glycosylation can improve the physico-chemical (drug-like) properties of peptide based drug candidates.
Michelle P Christie +8 more
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Increased Serum Met-enkephalin Level in Patients with Intrahepatic Cholestasis of Pregnancy
Bagcilar Medical Bulletin, 2022 Objective:To evaluate met-enkephalin levels in women with intrahepatic cholestasis of pregnancy (ICP) by comparison to healthy controls and to compare the pregnancy outcomes.Method:This cross-sectional study was conducted in 43 pregnant women with ICP ...
Sema Süzen Çaypınar, Murat Ekin
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Metropolis simulations of Met-Enkephalin with solvent-accessible area parameterizations [PDF]
, 2003 We investigate the solvent-accessible area method by means of Metropolis simulations of the brain peptide Met-Enkephalin at 300$ K$. For the energy function ECEPP/2 nine atomic solvation parameter (ASP) sets are studied. The simulations are compared with
A.H. Juffer +34 more
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