Iraqi Journal of Pharmaceutical Sciences, 2017 A small number of researches were done in the design and synthesis of enkephalin analogues that are able to resist degradation effect of proteolytic enzymes with good bioavailability and half-lives.Through studying structure activity relationships we ...
Muthanna S. Al-Ttaee +2 more
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Photodissociation of protonated Leucine-Enkephalin peptide in the VUV range
Journal of Physics: Conference Series, 2015 We present results of VUV action spectroscopy of gas-phase protonated Leucin-Enkephalin peptide. The experiment has been performed by coupling a linear quadrupole ion trap with a synchrotron radiation VUV ...
Canon, Francis +5 more
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Gegen Qinlian decoction alleviates depression-like behavior by modulating the gut microenvironment in CUMS rats [PDF]
BMC Complementary Medicine and TherapiesBackground Gegen Qinlian Decoction (GQD) is a classical traditional Chinese medicine (TCM) formula primarily utilized for treating gut disorders. GQD showed therapeutic effects on several diseases in clinical and animal studies by targeting gut microbes.
Yaqin Peng +13 more
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Role of enkephalin derivative in promoting wound healing and scar remodeling via increased epidermal growth factor in a mouse model [PDF]
Archives of Aesthetic Plastic Surgery, 2023 Background Enkephalin, an endogenous neuropeptide, binds to the delta (δ) opioid receptor and exerts an antinociceptive effect. Recent studies have suggested that neuropeptides might effectuate cutaneous wound healing.
Sun Eung Kim +2 more
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Exposure to exogenous enkephalins disrupts reproductive development in the Eastern lubber grasshopper, Romalea microptera (Insecta: Orthoptera). [PDF]
PLoS ONE, 2012 Enkephalins play a major role in reproductive physiology in crustaceans; however their role in reproductive development in insects is largely unknown. We investigated the effect of exposure to exogenous leucine-enkephalin (Leu-Enk), methionine-enkephalin
Sandeep Kumar +4 more
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Active site mutations change the cleavage specificity of neprilysin. [PDF]
PLoS ONE, 2012 Neprilysin (NEP), a member of the M13 subgroup of the zinc-dependent endopeptidase family is a membrane bound peptidase capable of cleaving a variety of physiological peptides.
Travis Sexton +4 more
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THE DISTRIBUTION OF METHIONINE‐ENKEPHALIN AND LEUCINE‐ENKEPHALIN IN THE BRAIN AND PERIPHERAL TISSUES [PDF]
British Journal of Pharmacology, 1977 A method is described for the rapid extraction of opioid peptides from the brain and other tissues. The method is based on acid extraction of tissues followed by adsorption of the extract onto Amberlite XAD‐2 resin. Elution with methanol separates the enkephalins and α‐endorphin from β‐endorphin.Over 90% of the opioid peptide activity isolated from ...
Jeffery Hughes +2 more
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‘Acetaldehyde‐enkephalins’: elucidation of the structure of the acetaldehyde adducts of methionine‐enkephalin and leucine‐enkephalin [PDF]
FEBS Letters, 1980 The two major endogenous opioid pentapeptides, methionine-enkephalin and leucine-enkephalin [ 1,2] rapidly react with acetaldehyde, under very mild conditions, to give an ‘acetaldehyde-enkephalin’ adduct, referred to as ‘acetaldehyde-enkephalin [Met’] and ‘acetaldehyde-enkephalin [Leu”], respectively 231.
Summers, Michael C. +2 more
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Measurement of tissue azithromycin levels in self-collected vaginal swabs post treatment using liquid chromatography and tandem mass spectrometry (LC-MS/MS). [PDF]
PLoS ONE, 2017 Azithromycin is recommended for the treatment of uncomplicated urogenital chlamydia infection although the standard 1gram dose sometimes fails to eradicate the infection (treatment failure).
Lenka A Vodstrcil +12 more
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Frontiers in Medical Technology, 2021 Tyrosine-arginine (kyotorphin), an opioid analgesic dipeptide, was discovered more than 40 years ago in 1979. The evidence accumulated during this period has established the physiological significance of kyotorphin as a neuromodulating peptide, and ...
Hiroshi Ueda, Hiroshi Ueda, Hiroshi Ueda
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