Results 1 to 10 of about 126,781 (219)

Synthesis of New Opioid Analgesic Peptide Analogues to Enkephalin (Leucine- and Methionine-Enkephalin)

open access: yesIraqi Journal of Pharmaceutical Sciences, 2017
A small number of researches were done in the design and synthesis of enkephalin analogues that are able to resist degradation effect of proteolytic enzymes with good bioavailability and half-lives.Through studying structure activity relationships we ...
Muthanna S. Al-Ttaee   +2 more
doaj   +4 more sources

Enkephalin Leucine Microspheres Suspension as a Sustained Antiplaque Antimicrobial Delivery System

open access: yesAl-Mustansiriyah Journal of Pharmaceutical Sciences, 2010
The purpose of this study is to prepare a formulation containing enkephalin leucine as an antiplaque/antibacterial agent. Enkephalin leucine microspheres were prepared using a poly(D-L-lactide-co-glycolide) (PLGA) as a delivery system.
Laith H. Samein
doaj   +2 more sources

Photodissociation spectroscopy of protonated leucine enkephalin

open access: yesPhysical Chemistry Chemical Physics, 2017
The protonated pentapeptide leucine enkephaline (YGGFL) fragments upon absorption of multiple UV photons by the tyrosine chromophore, providing complete sequence coverage.
Andreas Herburger   +2 more
openaire   +4 more sources

Neuroprotective and neuroregenerative potential of pharmacologically-induced hypothermia with D-alanine D-leucine enkephalin in brain injury

open access: yesNeural Regeneration Research, 2018
Neurovascular disorders, such as traumatic brain injury and stroke, persist as leading causes of death and disability – thus, the search for novel therapeutic approaches for these disorders continues.
M Grant Liska   +3 more
doaj   +2 more sources

Effect of leucine enkephalin administration on ovarian maturation in the freshwater crab Travancoriana schirnerae

open access: yesInternational Journal of Aquatic Biology, 2019
The current study focused on the effect of administration of the neurotransmitter leucine enkephalin on ovarian maturation in the freshwater crab Travancoriana schirnerae.
Navya Gopal, Arath Raghavan Sudha Devi
doaj   +2 more sources

MALDI-induced fragmentation of leucine enkephalin, nitro-Tyr-leucine enkaphalin, and d5-Phe-nitro-Tyr-leucine enkephalin [PDF]

open access: yesInternational Journal of Mass Spectrometry, 2009
The long-term objective of this study is to use MALDI MS and MS/MS to study the fragmentation pattern of in vitro nitrotyrosine-containing peptides in order to assist the interpretation of MS-identification of endogenous nitroproteins in human tissues and fluids.
Xianquan, Zhan, Dominic M, Desiderio
openaire   +3 more sources

Leucine enkephalin—A mass spectrometry standard

open access: yesMass Spectrometry Reviews, 2011
AbstractThe present article reviews the mass spectrometric fragmentation processes and fragmentation energetics of leucine enkephalin, a commonly used peptide, which has been studied in detail and has often been used as a standard or reference compound to test novel instrumentation, new methodologies, or to tune instruments.
Sztáray, Judit   +3 more
openaire   +4 more sources

Photodissociation of protonated Leucine-Enkephalin peptide in the VUV range

open access: yes, 2015
We present results of VUV action spectroscopy of gas-phase protonated Leucin-Enkephalin peptide. The experiment has been performed by coupling a linear quadrupole ion trap with a synchrotron radiation VUV ...
Canon, Francis   +5 more
core   +4 more sources

THE DISTRIBUTION OF METHIONINE‐ENKEPHALIN AND LEUCINE‐ENKEPHALIN IN THE BRAIN AND PERIPHERAL TISSUES [PDF]

open access: yesBritish Journal of Pharmacology, 1977
A method is described for the rapid extraction of opioid peptides from the brain and other tissues. The method is based on acid extraction of tissues followed by adsorption of the extract onto Amberlite XAD‐2 resin. Elution with methanol separates the enkephalins and α‐endorphin from β‐endorphin.Over 90% of the opioid peptide activity isolated from ...
J, Hughes, H W, Kosterlitz, T W, Smith
openaire   +5 more sources

Light microscopic immunocytochemical identification of leucine enkephalin

open access: yesScripta Scientifica Medica, 2015
Leucine-enkephalin is a potent and naturally-occurring opioid peptide which serves to inhibit other neurotransmitters involved with pain perception, thereby reducing its emotional and physical impact. Nevertheless, there is little data in the literature concerning leucine-enkephalin-immunoreactivity (Leu-enk-ir) in the human claustrum.
Dimka V. Hinova-Palova   +8 more
openaire   +2 more sources

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