Results 21 to 30 of about 126,781 (219)

Three protected tetrapeptides [PDF]

open access: yes, 1996
The structures of three protected tetrapeptides, containing the Boc-Gly-Gly-Phe-X-OMe chain, tert-butoxycarbonyl-glycy-glycl-phenylalanine-leucine methyl ester dihydrate, Boc-Gly-Gly-L-Phe-D-Leu-OMe, C25H38N4O7·2H2O, tert-butoxycarbonyl-glycy-glycl ...
Casalone, Gianluigi, Fenude, Emma
core   +1 more source

‘Acetaldehyde‐enkephalins’: elucidation of the structure of the acetaldehyde adducts of methionine‐enkephalin and leucine‐enkephalin [PDF]

open access: yesFEBS Letters, 1980
The two major endogenous opioid pentapeptides, methionine-enkephalin and leucine-enkephalin [ 1,2] rapidly react with acetaldehyde, under very mild conditions, to give an ‘acetaldehyde-enkephalin’ adduct, referred to as ‘acetaldehyde-enkephalin [Met’] and ‘acetaldehyde-enkephalin [Leu”], respectively 231.
Summers, Michael C.   +2 more
openaire   +3 more sources

The Metabolic Inhibition Model Which Predicts the Intestinal Absorbability and Metabolizability of Drug: Theory and Experiment

open access: yesBiological Procedures Online, 1998
The intestinal absorption of analgesic peptides (leucine enkephalin and kyotorphin) and modified peptides in rat were studied. Although these peptides were not absorbed, the absorbability (absorption clearance) of these peptides were increased in the ...
Mizuma Takashi, Awazu Shoji
doaj   +1 more source

New Aspects of Thromboangiitis obliterans (von Winiwarter-Buerger's Disease) [PDF]

open access: yes, 1984
The existence of thromboangiitis obliterans as a clinical entity has been a matter of debate for many years. In contrast to other immunovasculitides there is no organ involvement while peripheral vessels are affected.
Berlit, Peter   +3 more
core   +1 more source

Comparative Analysis of Dalargin Pharmaceutical Substance Identification Methods

open access: yesРазработка и регистрация лекарственных средств, 2020
Introduction. The quality control of a medicinal product needs to be systematically improved in connection with a continuous increase in the requirements for the quality of medicines. When assessing the quality of substances and drugs, the most important
M. G. Shulzhenko   +5 more
doaj   +1 more source

A trigeminoreticular pathway: implications in pain. [PDF]

open access: yesPLoS ONE, 2011
Neurons in the caudalmost ventrolateral medulla (cmVLM) respond to noxious stimulation. We previously have shown most efferent projections from this locus project to areas implicated either in the processing or modulation of pain.
W Michael Panneton   +2 more
doaj   +1 more source

Actions of D-Ala2-D-Leu5-enkephalin and dynorphin A (1–17) on neocortical neurons in vitro [PDF]

open access: yes, 1984
Intracellular recordings were made from neocortical neurons in vitro. Application of D-Ala2-D-Leu5-enkephalin (DADL) by different methods produced a decrease in EPSP amplitude and in the amplitude of L-glutamate-induced depolarizations without changes in
B Sutor   +11 more
core   +1 more source

NADPH oxidase as a therapeutic target in Alzheimer\u27s disease [PDF]

open access: yes, 2008
At present, available treatments for Alzheimer\u27s disease (AD) are largely unable to halt disease progression. Microglia, the resident macrophages in the brain, are strongly implicated in the pathology and progressively degenerative nature of AD ...
Block, Michelle L
core   +4 more sources

Effects of Leucine-enkephalin on Catalase Activity and Hydrogen Peroxide Levels in the Haemolymph of the Pacific Oyster (Crassostrea gigas)

open access: yesMolecules, 2008
The nervous and immune systems of invertebrates can exchange informationthrough neuropeptides. Furthermore, some opioid peptides can function as endogenousimmune system messengers and participate in the regulation of the immune responses.
Hong-zhi Xu, Zhi-wei Chen, Dong-wu Liu
doaj   +1 more source

The Non-Human Primate Striatum Undergoes Marked Prolonged Remodeling during Postnatal Development

open access: yesFrontiers in Cellular Neuroscience, 2014
We examined the postnatal ontogeny of the striatum in rhesus monkeys (Macaca mulatta) to identify temporal and spatial patterns of histological and chemical maturation.
Lee J Martin, Linda C Cork
doaj   +1 more source

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