Results 41 to 50 of about 20,144 (188)

Photodissociation of protonated Leucine-Enkephalin peptide in the VUV range

, 2015
We present results of VUV action spectroscopy of gas-phase protonated Leucin-Enkephalin peptide. The experiment has been performed by coupling a linear quadrupole ion trap with a synchrotron radiation VUV ...
Canon, Francis, Cerovski, Victor Z., Giuliani, Alexandre, Milosavljević, Aleksandar R., Nahon, Laurent, Ranković, Milos Lj.   +5 more
core   +3 more sources

Opioid precursor protein isoform is targeted to the cell nuclei in the human brain [PDF]

, 2017
Background: Neuropeptide precursors are traditionally viewed as proteins giving rise to small neuropeptide molecules. Prodynorphin (PDYN) is the precursor protein to dynorphins, endogenous ligands for the kappa-opioid receptor.
Alkass, Kanar, Andersson, Malin, Bakalkin, Georgy, Bazov, Igor, Druid, Henrik, Dyachok, Oleg, Gerashchenko, Ganna, Kononenko, Olga, Krishtal, Oleg, Mulder, Jan, Rajkowska, Grazyna, Stockmeier, Craig A, Svenningsen, Asa Fex, Verbeek, Dineke S., Watanabe, Hiroyuki, Yakovleva, Tatiana   +15 more
core   +2 more sources

Thermometer Ions, Internal Energies, and In‐Source Fragmentation in Ambient Ionization

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Ionization and fragmentation are at the core of mass spectrometry. But they are not necessarily separated in space, as in‐source fragmentation can also occur. Here, we survey the literature published since our 2005 review on the internal energy and fragmentation in electrospray ionization sources.
Emilie Bertrand, Valérie Gabelica
wiley   +1 more source

Design of Experiments (DoE)‐Optimized Polymeric Oxytocin Nanoparticles for Enhanced Nose‐to‐Brain Delivery

Small, EarlyView.
Intranasal (IN) delivery of PEGylated PLGA nanoparticles (NPs) loaded with oxytocin (OT) (OT‐NP‐PEG) is investigated as a strategy to enhance OT transport to the brain for treating autism and other neuropsychiatric disorders. The optimized NP formulation demonstrates appropriate physicochemical characteristics, improved stability, and enhanced mucosal ...
Naveed Ahmad, Shunping Han, Rifka Utami, Rafal Baker, Dina Helal, Zhuoni Li, Mark Tricklebank, Yannis Paloyelis, Julie Wang, Marija M. Petrinovic, Sukhi Bansal, Khuloud T. Al‐Jamal   +11 more
wiley   +1 more source

Serotoninergic, peptidergic and GABAergic innervation of the ventrolateral and dorsolateral motor nuclei in the cat S1/S2 segments: An immunofluorescence study [PDF]

, 1994
Indirect single- and double-staining immunofluorescence techniques were used to study the serotoninergic, peptidergic and GABAergic innervation of the ventrolateral (Onuf's nucleus) and dorsolateral (innervating intrinsic foot sole muscles) nuclei ...
Arvidsson, U. (U.), Hökfelt, T. (T.), Ramírez-León, V. (V.), Ulfhake, B. (B.), Verhofstad, A.A. (Albert), Visser, T.J. (Theo)   +5 more
core   +1 more source

Molecular basis of domain‐specific angiotensin I‐converting enzyme inhibition by the antihypertensive drugs enalaprilat, ramiprilat, trandolaprilat, quinaprilat and perindoprilat

The FEBS Journal, EarlyView.
Inhibition of angiotensin I‐converting enzyme is an effective strategy for the treatment of hypertension. However, the clinically available ACE inhibitors cause side effects due to nonselective inhibition of the two catalytic domains of ACE (nACE and cACE).
Kyle S. Gregory, Vinasha Ramasamy, Edward D. Sturrock, K. Ravi Acharya   +3 more
wiley   +1 more source

Stable Nitrogen Isotope Analysis of Amino Acids by Orbitrap Mass Spectrometry: Application for Extraterrestrial Samples

Rapid Communications in Mass Spectrometry, Volume 39, Issue 23, 15 December 2025.
ABSTRACT Background Obtaining isotopic data on soluble organic compounds, such as amino acids, in extraterrestrial samples is crucial for understanding their origins, prebiotic chemistry, and potential contamination. Conventional GC‐IRMS requires grams of material to measure isotopic compositions, limiting the analysis of low‐concentration organics in ...
O. M. McIntosh, A. A. Baczynski, M. Matney, H. L. McLain, K. K. Farnsworth, J. P. Dworkin, D. P. Glavin, J. E. Elsila, H. Xie, K. H. Freeman   +9 more
wiley   +1 more source

UPLC–ESI–QToF–MS Profile of Hydroalcoholic Extract of Persea cordata (Meisn.) and its Antioedematogenic and Antinociceptive Effects in Mice

Chemistry &Biodiversity, Volume 22, Issue 12, December 2025.
Hydroalcoholic crude extract of Persea cordata showed in its composition, the presence of lignans based on LCESIMS data. This crude extract displayed anti‐oedematogenic and antinociceptive activities in vivo. Abstract This study aimed to establish the chemical profile and evaluate the anti‐oedematogenic and analgesic activities of the hydroalcoholic ...
Valfredo Schlemper, Daniela Hemsing, Julia Elisabett K. Bolsonello, Susana R. de Mello Schlemper, Tiago Tizziani, Lutuima A. Capangue Neto, Louis P. Sandjo   +6 more
wiley   +1 more source

Use of quadrupole time-of-flight mass spectrometry for proposal of transformation products of the herbicide bromacil after water chlorination [PDF]

, 2011
The herbicide bromacil has been extensively used in the Spanish Mediterranean region, and although plant protection products containing bromacil have been withdrawn by the European Union, this compound is still frequently detected in surface and ground ...
Hernandez, Felix, Ibáñez, Maria, Pozo, Óscar J., Sancho, Juan V   +3 more
core   +3 more sources

N‐Geranylated Amino Acid Surfactants with Low Critical Micelle Concentrations from Abundant, Naturally Derived Starting Materials

ChemistryOpen, Volume 14, Issue 12, December 2025.
Cleaning Up Surfactants: Realising critical micelle concentrations lower than sodium dodecyl sulfate with sustainable surfactants prepared from amino acids and naturally occurring aldehydes. In this work, a simple method for the preparation of N‐alkylated amino acid surfactants in 1–2 steps is reported.
Brett L. Pollard, Yumeng Liu, Michael G. Gardiner, Luke A. Connal   +3 more
wiley   +1 more source