Results 21 to 30 of about 5,668 (135)

Methionine-enkephalin-treatment suppresses the pituitary-ovary axis in the cichlid fish Oreochromis mossambicus

Aquaculture Reports, 2020
The involvement of endogenous opioid peptides in regulation of reproductive activity is implicated in a majority of vertebrates. Methionine-enkephalin (M-ENK) is an endogenous opioid peptide neurotransmitter produced in the central nervous system ...
C.B. Ganesh, Vijayalaxmi
doaj   +1 more source

Maturation of Circulatory Responses to Methionine-Enkephalin [PDF]

Pediatric Research, 1983
The cardiovascular and respiratory effects of the naturally occurring endogenous opiate, methionine-enkephalin, were studied in 23 fetal sheep, five newborn lambs, 15 pregnant sheep, and four nonpregnant ewes. The opiate peptide produced dose-dependent decreases in heart rate and blood pressure in fetal and neonatal lambs but increased heart rate and ...
Abraham M. Rudolph, Edmund F. LaGamma, Joseph Itskovitz   +2 more
openaire   +3 more sources

Methionine-enkephalin and leucine-enkephalin in human sympathoadrenal system and pheochromocytoma. [PDF]

Journal of Clinical Investigation, 1982
To elucidate the physiological and pathophysiological significance of methionine- and leucine-enkephalin (Met-and Leu-enkephalin, respectively) in human sympathoadrenal system, the contents of these peptides in normal human sympathetic nervous system, adrenal medulla, and pheochromocytomas were determined by specific radioimmunoassays combined with ...
Hiroo Imura, Shozo Li, Kazuwa Nakao, Hitoshi Ohtsuki, Takaaki Yoshimasa   +4 more
openaire   +2 more sources

Targeted Cell Reprogramming Produces Analgesic Chromaffin-Like Cells from Human Mesenchymal Stem Cells

Cell Transplantation, 2013
Transplantation of allogeneic adrenal chromaffin cells demonstrated the promise of favorable outcomes for pain relief in patients. However, there is a very limited availability of suitable human adrenal gland tissues, genetically well-matched donors in ...
T. Qu M.D., Ph.D., G. Shi, K. Ma, H. N. Yang, W. M. Duan, G. D. Pappas   +5 more
doaj   +1 more source

Methionine Enkephalin Suppresses Osteocyte Apoptosis Induced by Compressive Force through Regulation of Nuclear Translocation of NFATc1

JBMR Plus, 2020
Mechanical stress stimulates bone remodeling, which occurs through bone formation and resorption, resulting in bone adaptation in response to the mechanical stress. Osteocytes perceive mechanical stress loaded to bones and promote bone remodeling through
Chisumi Sogi, Nobuo Takeshita, Wei Jiang, Siyoung Kim, Toshihiro Maeda, Michiko Yoshida, Toshihito Oyanagi, Arata Ito, Seiji Kimura, Daisuke Seki, Ikuko Takano, Yuichi Sakai, Ikuma Fujiwara, Shigeo Kure, Teruko Takano‐Yamamoto   +14 more
doaj   +1 more source

Backbone Protecting Groups for Enhanced Peptide and Protein Synthesis

Angewandte Chemie, Volume 137, Issue 33, August 11, 2025.
This review provides a comprehensive account of the use of backbone N‐protecting groups in peptide synthesis. It includes detailed synthetic methods relating to their introduction and removal and their application to “difficult” peptides and proteins of biological significance in both academic and industry contexts.
Samuel J. Paravizzini, Linda M. Haugaard‐Kedström, Craig A. Hutton, John A. Karas   +3 more
wiley   +2 more sources

Genetically Engineered Human Mesenchymal Stem Cells Produce Met-Enkephalin at Augmented Higher Levels in Vitro

Cell Transplantation, 2006
We have reported that transplantation of adrenal medullary chromaffin cells that release endogenous opioid peptides into pain modulatory regions in the CNS produce significant antinociceptive effects in patients with terminal cancer pain.
Ikuko Sugaya, Tingyu Qu, Kiminobu Sugaya, George D. Pappas   +3 more
doaj   +1 more source

Biomimetic Chemistry on Tandem Protein/Lipid Damages under Reductive Radical Stress

CHIMIA, 2008
The study of radical stress in the biological environment needs a comprehensive vision of all possible reactive species and their mechanisms. Among them, reductive stress is evaluated for its selective target of sulfur-containing compounds.
Sílvia Atrian, Krzysztof Bobrowski, Mercè Capdevila, Chryssostomos Chatgilialoglu, Carla Ferreri, Chantal Houée-Levin, Anna Maria Salzano, Andrea Scaloni, Armida Torreggiani   +8 more
doaj   +1 more source

Cerebrospinal Fluid Proenkephalin Predicts Striatal Atrophy Decades before Clinical Motor Diagnosis in Huntington's Disease

Movement Disorders, EarlyView.
Abstract Background Huntington's disease (HD) is characterized by early, selective, progressive vulnerability of striatal medium spiny neurons (MSNs). Proenkephalin (PENK), a precursor of opioid peptides abundantly expressed in MSNs, is a promising biomarker of striatal integrity, but region‐specific associations and its potential for early‐stage ...
Mena Farag, Michael J. Murphy, Nicola Z. Hobbs, Michela Leocadi, Kate Fayer, Olivia Thackeray, Johan Gobom, Marc Ciosi, Amanda Heslegrave, Henrik Zetterberg, Douglas R. Langbehn, Darren G. Monckton, Edward J. Wild, Sarah J. Tabrizi, Rachael I. Scahill   +14 more
wiley   +1 more source

Characterization and Identification of Potential Antioxidant, Antidiabetic, and Antihypertensive Peptides From Hydrolysates of Tenebrio molitor Flour and Its Protein Concentrate

Journal of Food Science, Volume 90, Issue 10, October 2025.
ABSTRACT Insects are recognized as a potential alternative source of proteins and have been studied in recent years as a substrate for enzymatic hydrolysis to obtain bioactive peptides. This study aimed to evaluate the production of hydrolysates with antioxidant, antidiabetic, and antihypertensive properties from mealworm (Tenebrio molitor) flour and ...
Francielle Miranda de Matos, Ruann Janser Soares de Castro   +1 more
wiley   +1 more source