Results 31 to 40 of about 5,668 (135)

Nicotine Effects and the Endogenous Opioid System

Journal of Pharmacological Sciences, 2014
.: Nicotine (NIC) is an exogenous ligand of the nicotinic acetylcholine receptor (nAChR), and it influences various functions in the central nervous system. Systemic administration of NIC elicits the release of endogenous opioids (endorphins, enkephalins,
Shiroh Kishioka, Norikazu Kiguchi, Yuka Kobayashi, Fumihiro Saika   +3 more
doaj   +1 more source

Lentil Flours as Sustainable Source of Proteins for the Food Industry

Sustainable Food Proteins, Volume 3, Issue 3, September 2025.
Lentils, due to their accessibility, sustainability, and high nutritional value, emerge as a promising option as protein flour for food development. This study evaluated different functional and nutritional properties of lentil flours. ABSTRACT The growing transition toward a plant‐based diet, coupled with the need for sustainable dietary protein ...
S. M. Pontoni, A.G. Garzón, G. D. Heinen, S.R. Drago   +3 more
wiley   +1 more source

Sensory Neuropeptides and Endogenous Opioids Expression in Human Dental Pulp with Asymptomatic Inflammation: In Vivo Study

Mediators of Inflammation, 2015
Purpose. This study quantified the expression of substance P (SP), calcitonin gene-related peptide (CGRP), β-endorphins (β-End), and methionine-enkephalin (Met-Enk) in human dental pulp following orthodontic intrusion. Methods.
Daniel Chavarria-Bolaños, Hector Flores-Reyes, Nelson Lombana-Sanchez, Bernardino Cerda-Cristerna, Amaury Pozos-Guillen   +4 more
doaj   +1 more source

New analogues of leucine-methionine-enkephalin

Journal of Biosciences, 1988
Nine analogues of the opioid pentapeptides leucine-/ methionine-enkephalinamide, involving replacement of amino acid at position 5 or amino acids at positions 2 and 5, have been synthesized by the solid phase method using mainly 9-fluorenylmethyloxycarbonyl amino acid trichlorophenyl esters in the presence of 1-hydroxybenzotriazole, the solid support ...
Sivanandaiah, K.M., Gurusiddappa, S., Channegowda, C.   +2 more
openaire   +3 more sources

Changes in Liver Metabolome Induced by Pterostilbene and Resveratrol in a Rat Model of Liver Steatosis

Molecular Nutrition &Food Research, Volume 69, Issue 15, August 2025.
Resveratrol and pterostilbene reduced the steatotic status of animals fed a high‐fat, high‐sucrose diet, involving differential and specific mechanisms of action for each stilbene. Thus, changes in riboflavin metabolism, nicotinamide mononucleotide metabolism, or in the LysoPC(18:1)‐mediated effects contribute to the specific actions of pterostilbene ...
Alfredo Fernández‐Quintela, Emily P. Laveriano‐Santos, Tania Portolés, Andreu Gual‐Grau, Juan Vicente Sancho, Maria P. Portillo   +5 more
wiley   +1 more source

Opioid receptors in cardiovascular function

British Journal of Pharmacology, Volume 182, Issue 16, Page 3710-3725, August 2025.
Opioid receptors are G protein‐coupled receptors expressed by various cells in the heart, including myocytes and nerve fibres, and play a crucial role in modulating cardiac function. These receptors influence neural transmission, heart rate and myocyte contractility, offering cardioprotection.
Venkatesh Katari, Kesha K. Dalal, Narendra Kondapalli, Sailaja Paruchuri, Charles K. Thodeti   +4 more
wiley   +1 more source

Kinetics of chymotrypsin- and papain-catalysed synthesis of [leucine]enkephalin and [methionine]enkephalin [PDF]

Biochemical Journal, 1984
The proteinase-catalysed synthesis of [Leu]enkephalin and [Met]enkephalin was studied kinetically. N alpha-t-Butoxycarbonyl-amino acids and peptides or their ethyl esters served as acyl donors, and amino acid phenylhydrazides were used as acyl acceptors.
openaire   +3 more sources

Hyperpolarization Modulation of the T‐Type hCav3.2 Channel by Human Synenkephalin [1–53], a Shrew Neurotoxin Analogue without Paralytic Effects

Angewandte Chemie, Volume 137, Issue 27, July 1, 2025.
Human synenkephalin [1–53] (hSYN), an analogue peptide of shrew saliva neurotoxins, was synthesized and its structural characteristics studied. Synthetic hSYN potently activated the T‐type voltage‐gated Ca channel hCav3.2 but did not paralyze mealworms. These findings offer new insight into neurological disorder treatment and evolutionary mechanisms of
Ryo Fukuoka, Yusuke Yano, Nozomi Hara, Chihiro Sadamoto, Andres D. Maturana, Masaki Kita   +5 more
wiley   +1 more source

Methionine enkephalin (MENK) protected macrophages from ferroptosis by downregulating HMOX1 and ferritin

Proteome Science
Objective The aim of this work was to investigate the immunological effect of MENK by analyzing the protein spectrum and bioinformatics of macrophage RAW264.7, and to explore the relationship between macrophage and ferroptosis.
Jing Tian, Wenrui Fu, Zifeng Xie, Yuanlong Zhao, Haochen Yang, Jiafan Zhao   +5 more
doaj   +1 more source

Multi‐Omics Analyses on Maya‐Land Tomatoes Shed Light on Plant Strategies to Thrive in High Temperatures

Physiologia Plantarum, Volume 177, Issue 4, July/August 2025.
ABSTRACT Heat stress limits tomato yield and quality. Deciphering the key genes and metabolites related to heat tolerance is essential for selecting tolerant varieties. In this study, we profiled the transcriptomes and metabolomes of roots and shoots in response to heat stress from a Maya‐land ecotype of heirloom tomato (Calkiní), which grows in ...
Luis F. Maceda‐López, Annie Espinal‐Centeno, Jose Juan Ordaz‐Ortiz, Alfredo Cruz‐Ramírez   +3 more
wiley   +1 more source