Results 41 to 50 of about 9,174 (179)

Nicotine Effects and the Endogenous Opioid System

Journal of Pharmacological Sciences, 2014
.: Nicotine (NIC) is an exogenous ligand of the nicotinic acetylcholine receptor (nAChR), and it influences various functions in the central nervous system. Systemic administration of NIC elicits the release of endogenous opioids (endorphins, enkephalins,
Shiroh Kishioka, Norikazu Kiguchi, Yuka Kobayashi, Fumihiro Saika   +3 more
doaj   +1 more source

Electron scattering from molecules and molecular aggregates of biological relevance [PDF]

, 2017
In this Topical Review we survey the current state of the art in the study of low energy electron collisions with biologically relevant molecules and molecular clusters.
Allan M, Allan M, Bouchiha D, Calegari F, Caprasecca S, Colyer C J, Colyer C J, da Costa R F, Denifl S, Dora A, Dubernet M L, Fabrikant I I, Fabrikant I I, Ferlay J, Fujimoto M M, Hall E, Herbert J M ed Parrill A L, Jensen F, Jimena D Gorfinkiel, Keller A, Linert I, Marangos J P, Nikjoo H, Ryszka M, Samukawa S, Slaughter D S, Surko C M, Sylwia Ptasinska, Trevisan C S, Vizcaino V, Winstead C, Zecca A, Zubek M, Ómarsson B   +33 more
core   +1 more source

Opioid Receptors in Immune and Glial Cells-Implications for Pain Control [PDF]

, 2020
Opioid receptors comprise μ (MOP), δ (DOP), κ (KOP), and nociceptin/orphanin FQ (NOP) receptors. Opioids are agonists of MOP, DOP, and KOP receptors, whereas nociceptin/orphanin FQ (N/OFQ) is an agonist of NOP receptors.
Celik, Melih Ö., Machelska, Halina
core   +1 more source

Maturation of Circulatory Responses to Methionine-Enkephalin [PDF]

Pediatric Research, 1983
The cardiovascular and respiratory effects of the naturally occurring endogenous opiate, methionine-enkephalin, were studied in 23 fetal sheep, five newborn lambs, 15 pregnant sheep, and four nonpregnant ewes. The opiate peptide produced dose-dependent decreases in heart rate and blood pressure in fetal and neonatal lambs but increased heart rate and ...
E F, Lagamma, J, Itskovitz, A M, Rudolph
openaire   +2 more sources

A Hanks‐type bacterial kinase, PknS, directly phosphorylates the alternative sigma factor EcfK to promote resistance to protist predation

The FEBS Journal, EarlyView.
The Xanthomonas citri Hanks‐type kinase PknS autophosphorylates and directly phosphorylates the alternative sigma factor EcfK at five residues. Besides the conserved residue T51 in the σ2 domain, phosphorylation of a residue in the linker between σ2 and σ4 is critical for EcfK activation by promoting its interaction with a positively charged pocket in ...
Lídia dos Passos Lima, Dev Sriranganadane, Daiane Laise da Silva, Natália C. Drebes Dörr, Enzo Breviglieri Sichi Mello, Caio Vinicius dos Reis, Rogério Ferreira Lourenço, José Felipe Teixeira da Silva Santos, Anita Salmazo, Brenno Wendler Miranda, Katlin B. Massirer, Rafael M. Couñago, Cristina E. Alvarez‐Martinez   +12 more
wiley   +1 more source

Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens. [PDF]

, 2010
Despite abundant expression of DNA methyltransferases (Dnmts) in brain, the regulation and behavioral role of DNA methylation remain poorly understood. We found that Dnmt3a expression was regulated in mouse nucleus accumbens (NAc) by chronic cocaine use ...
Bolaños, Carlos A, Covington, Herbert E, Dietz, David M, Dumitriu, Dani, Eisch, Amelia J, Fan, Gouping, Feng, Jian, Hollis, Fiona, Hurd, Yasmin L, Iñiguez, Sergio D, Kabbaj, Mohamed, Koo, Ja Wook, LaPlant, Quincey, Maze, Ian, Morrison, John H, Mouzon, Ezekiell, Nestler, Eric J, Neve, Rachael L, Noonan, Michele A, Oosting, Ronald S, Ren, Yanhua, Renthal, William, Vialou, Vincent, Wang, Hui, Warren, Brandon L, Watts, Emily L, Xiao, Guanghua   +26 more
core   +3 more sources

Mass Spectrometry Imaging Combined With Single‐Cell Transcriptional Profiling Reveals the Multidimensional Spatial Distributions and Biosynthetic Pathways of Medicinal Components in Andrographis paniculata

Plant Biotechnology Journal, EarlyView.
ABSTRACT The synthesis and accumulation of active ingredients in medicinal plants are distributed in specific organs, tissues, and cell types, which are important for the exploitation of medicinal plants. However, the fine distribution of active ingredients is difficult to know. Here, the system of mass spectrometry imaging (MSI) integrated with single‐
HaiSheng Zeng, MeiHui Shi, ZhiRong Chen, XueJing Sun, HuiJie Zhang, Yue Huang, YuCheng Chen, Jun Ren, HuiLing Huang, Almaz Borjigidai, Man Zhang, SuJuan Duan, Yi‐Jun Chen, Hong‐Lei Jin, Hong‐Bin Wang   +14 more
wiley   +1 more source

Sensory Neuropeptides and Endogenous Opioids Expression in Human Dental Pulp with Asymptomatic Inflammation: In Vivo Study

Mediators of Inflammation, 2015
Purpose. This study quantified the expression of substance P (SP), calcitonin gene-related peptide (CGRP), β-endorphins (β-End), and methionine-enkephalin (Met-Enk) in human dental pulp following orthodontic intrusion. Methods.
Daniel Chavarria-Bolaños, Hector Flores-Reyes, Nelson Lombana-Sanchez, Bernardino Cerda-Cristerna, Amaury Pozos-Guillen   +4 more
doaj   +1 more source

Interaction and Localization of One-electron Orbitals in an Organic Molecule: Fictitious Parameter Analysis for Multi-physics Simulations

, 2006
We present a new methodology to analyze complicated multi-physics simulations by introducing a fictitious parameter. Using the method, we study quantum mechanical aspects of an organic molecule in water.
Bies W. E., Brody T. A., Gaspard P., Hirata F., Inadomi Y., Kitaura K., Lee M.-I., Levit S., Machida M., Matsuoka S., Ogata S., Roothaan C. C. J., Sato H., Sato H., Sato T., Takami T., Takami T., Takami T., Takami T., Ten-no S., Ten-no S., Timberlake T., Yoshida N., Zakrzewski J., Zakrzewski J.   +24 more
core   +1 more source

Metabolic signatures of the integrated profile of cardiovascular autonomic modulation and cardiorespiratory fitness in apparently healthy individuals

Physiological Reports, Volume 14, Issue 2, January 2026.
Abstract Cardiovascular autonomic modulation (CAM) and cardiorespiratory fitness (CRF) are well‐established predictors of health. Identifying metabolites associated with integrated CAM‐CRF profiles may help characterize healthy physiological states.
Étore De Favari Signini, Alex Castro, Patrícia Rehder‐Santos, Juliana Cristina Milan‐Mattos, Juliana Magalhães de Oliveira, Alberto Porta, Renato Lajarim Carneiro, Antônio Gilberto Ferreira, Regina Vincenzi Oliveira, Aparecida Maria Catai   +9 more
wiley   +1 more source