Results 41 to 50 of about 5,668 (135)

Discovery, Herbicidal Activity and Biosynthesis of a Novel Natural Tetramic Acid from Alternaria Species

Advanced Science, Volume 12, Issue 21, June 5, 2025.
The biosynthetic mechanism of novel natural tetramic acid S‐TeA in Alternaria alternata is elucidated. Threonine acts as a precursor for 2‐amino‐3‐methylhexanoic acid (AMHA) synthesis via eight key enzymes from the branched‐chain amino acid biosynthetic pathway in the mitochondrion, wherein three unique enzymes (IPMS, IPMDH, and ISMD) play critical ...
He Wang, Yanjing Guo, Qing Liu, Jing Zhang, Qianlong Zhang, Mingying Yang, Qizhen Chen, Sheng Qiang, Bernal E. Valverde, Shiguo Chen   +9 more
wiley   +1 more source

Rational Design of Single‐Domain Antibodies Targeting the Central Nervous System Neurite Outgrowth Inhibitor Nogo‐A

Applied Research, Volume 4, Issue 3, June 2025.
The development of a nanobody for Nogo‐A, a potent neurite outgrowth inhibitor crucial in multiple sclerosis, is reported using a rational design approach. The nanobody targets the Nogo‐A ectodomain at the S1PR2 receptor‐binding region with submicromolar KD.
Vaidehi Roy Chowdhury, Alexander Röntgen, Matthew Greenig, Yanira Méndez Gómez, Sebastian P. Spiegel, Magdalena Nowinska, Aubin Ramon, Pietro Sormanni, Andrew Chan, Michele Vendruscolo   +9 more
wiley   +1 more source

Evidence of Involvement of the Calcitonin Gene‐Related Peptide in Restless Legs Syndrome

Movement Disorders, Volume 40, Issue 6, Page 1148-1159, June 2025.
Abstract Background Restless legs syndrome (RLS) is a common sensory‐motor disorder characterized by an urge to move the legs, often with unpleasant sensations, particularly during rest. Current treatments include iron supplementation, dopamine agonists, and opioids, but new therapeutic approaches are needed.
Maria P. Mogavero, Mojibola Fowowe, Akeem Sanni, Mona Goli, Giuseppe Lanza, Francesca L'Episcopo, Luigi Ferini‐Strambi, Yehia Mechref, Raffaele Ferri   +8 more
wiley   +1 more source

N‐ to C‐Peptide Synthesis, Arguably the Future for Sustainable Production

Journal of Peptide Science, Volume 31, Issue 6, June 2025.
The advent of epimerization‐free methods for coupling in N‐ to C‐direction synthesis offers improved atom economy for sustainable peptide synthesis. ABSTRACT A revolution in peptide production arrived from the innovation of carboxylate to amine C‐ to N‐direction solid‐phase synthesis.
Kinshuk Ghosh, William D. Lubell
wiley   +1 more source

Proteo‐metabolomic insights for early dual physical and cognitive impairments: A search for biomarkers of healthy aging based on muscle–brain crosstalk

Aging Cell, Volume 24, Issue 3, March 2025.
The study identified dysregulated fatty acid metabolism and inflammation as contributors to physio‐cognitive decline syndrome (PCDS). Sex‐specific metabolic disruptions were noted, with altered central carbon and tyrosine metabolism more pronounced in men and glutathione pathway perturbations more evident in women.
Yi‐Long Huang, Wei‐Ju Chang, Chen‐Hua Huang, Chao‐Hsiung Lin, Li‐Ning Peng, Chih‐Ping Chung, Liang‐Kung Chen, Wei‐Ju Lee   +7 more
wiley   +1 more source

Catalytic Serine Labeling in Nonaqueous, Acidic Media

Chemistry – A European Journal, Volume 31, Issue 12, February 25, 2025.
Serine‐targeting protein bioconjugation has been a formidable challenge because of the modest reactivity of the alkyl alcohol group in aqueous media. This work demonstrates a biomolecule‐compatible, nonaqueous approach to achieve alkyl alcohol‐selective labeling through acid‐catalyzed esterification reactions, which offers a unique advantage over the ...
Seiya Ishizawa, Chiamaka P. Uzoewulu, Yume Iwakura, Anuja Koirala, Shinichi Sato, Jun Ohata   +5 more
wiley   +1 more source

Rh‐Catalyzed Hydroamination of Allenes: Asymmetric N‐Allylation of Amino Acids and Peptides

ChemistryEurope, Volume 2, Issue 5, September 9, 2024.
A rhodium‐catalyzed, atom‐economic method for the branched‐selective hydroamination of terminal allenes with α‐amino acid esters is reported. High levels of enantio‐ and diastereoselectivity were achieved by using commercially available ligands, with complete catalyst control demonstrated in several products.
Edward Damer, Bernhard Breit
wiley   +1 more source

Electroacupuncture attenuates retinal ischemia/reperfusion injury by protecting the outer blood-retina barrier via enkephalins activate delta opioid receptor

World Journal of Acupuncture - Moxibustion
Objectives: Retinal ischemia-reperfusion (RIR) injury results in irreversible visual impairments. The disruption of the outer blood-retinal barrier (OBRB) is a major ocular pathogenic process that RIR injury affects.
Ping CHEN, Xian-dan ZHU, Run-jie GUO, Yong XIA, Jing-ling JIN, Nan-ge JIN, Ying-min GU, Xue-song TIAN   +7 more
doaj   +1 more source

The novel mechanism of anticancer effect on gastric cancer through inducing G0/G1 cell cycle arrest and caspase-dependent apoptosis in vitro and in vivo by methionine enkephalin

Cancer Management and Research, 2018
Xiaonan Wang,1 Jing Tian,1 Xue Jiao,2 Jin Geng,3 Reizhe Wang,4 Ning Liu,5 Xinghua Gao,6 Noreen Griffin,7 Yuan Gao,8 Fengping Shan1 1Department of Immunology, College of Basic Medical Science, China Medical University, Shenyang, China; 2Department of ...
Wang X, Tian J, Jiao X, Geng J, Wang R, Liu N, Gao X, Griffin N, Gao Y, Shan F   +9 more
doaj  

Synthesis of methionine-5-enkephalin [PDF]

Chemistry of Natural Compounds, 1979
Yu. P. Shvachkin, A. A. Shishkina, A. P. Smirnova, N. I. Cherkashina   +3 more
openaire   +2 more sources