Results 41 to 50 of about 110,810 (218)

Opioid receptors in cardiovascular function

British Journal of Pharmacology, EarlyView.
Opioid receptors are G protein‐coupled receptors expressed by various cells in the heart, including myocytes and nerve fibres, and play a crucial role in modulating cardiac function. These receptors influence neural transmission, heart rate and myocyte contractility, offering cardioprotection.
Venkatesh Katari, Kesha K. Dalal, Narendra Kondapalli, Sailaja Paruchuri, Charles K. Thodeti   +4 more
wiley   +1 more source

Biochemical and clinical impact of organic uremic retention solutes : a comprehensive update [PDF]

, 2018
In this narrative review, the biological/biochemical impact (toxicity) of a large array of known individual uremic retention solutes and groups of solutes is summarized.
Abel, Amann, Anneleen Pletinck, Barreto, Brownlee, Cohen, Costigan, Dhaun, Drewett, Eva Schepers, Glorieux, Griet Glorieux, Hannam-Harris, Harpel, Henderson, Hur, Kassis, Kohan, Koizumi, Kuragano, Lim, Nilsson, Niwa, Niwa, Palmer, Patel, Raymond Vanholder, Rhee, Rock, Rubin, Saxena, Sheriff, Simenhoff, Tschesche, Vadas, Vallance, Vanholder, Vanholder, Vanholder, Vannucchi, Ward, Warren, Witko-Sarsat, Yan, Zoccali, Zoccali   +45 more
core   +3 more sources

Untargeted metabolomics approach for unraveling robust biomarkers of nutritional status in fasted gilthead sea bream (Sparus aurata) [PDF]

, 2017
A metabolomic study has been performed to identify sensitive and robust biomarkers of malnutrition in farmed fish, using gilthead sea bream (Sparus aurata) as a model.
Calduch-Giner, Josep, Gil Solsona, Ruben, Hernandez, Felix, Lacalle-Bergeron, Leticia, Nácher Mestre, Jaime, Pérez Sánchez, Jaume, Vicente Sancho, Juan   +6 more
core   +3 more sources

Human hepatic met-enkephalin and delta opioid receptor-1 immunoreactivities in viral and autoimmune hepatitis

Annals of Hepatology, 2008
Endogenous opioids participate in growth regulation. Liver regeneration relates to growth. Thus, we explored the expression of methionine enkephalin and of the delta opioid receptor 1 immunoreactivities with a polyclonal rabbit antibody in deparaffinized
Vijaya D. Boyella, Anthony D. Nicastri, Nora V. Bergasa   +2 more
doaj  

New analogues of leucine-methionine-enkephalin

Journal of Biosciences, 1988
Nine analogues of the opioid pentapeptides leucine-/ methionine-enkephalinamide, involving replacement of amino acid at position 5 or amino acids at positions 2 and 5, have been synthesized by the solid phase method using mainly 9-fluorenylmethyloxycarbonyl amino acid trichlorophenyl esters in the presence of 1-hydroxybenzotriazole, the solid support ...
Sivanandaiah, K.M., Gurusiddappa, S., Channegowda, C.   +2 more
openaire   +3 more sources

The distribution of enkephalinlike immunoreactivity in the telencephalon of the adult and developing domestic chicken [PDF]

, 1984
Immunohistochemical techniques were used to determine the distribution of enkephalinlike immunoreactivity in the telencephalon of chicken. The densest accumulation of enkephalinergic neurons and fibers was observed within the paleostriatal complex, the ...
Ariens-Kappers, Bayon, Bertler, Blähser, Brauth, Brauth, Carpenter, Comb, Coons, Cuello, De Lanerolle, Del Fiacco, Dube, Fuxe, Gall, Haber, Hamberger, Heimer, Herrick, Jessell, Jocobowitz, Juorio, Kanazawa, Karten, Karten, Karten, Khachaturian, Khachaturian, Kitt, Kuhar, Källén, Källén, Ljungdahl, McLean, Miller, Naik, Nauta, Nauta, Nauta, Newman, Newman, Nicoll, Noda, Palkovits, Parent, Parent, Parent, Pert, Pickel, Reiner, Reiner, Reiner, Reiner, Sar, Sidman, Simantov, Simantov, Simantov, Sternberger, Switzer, ten Donkelaar, Tsai, Tsai, Van Tienhoven, Vincent, Wamsley, Watson, Weber, Younger   +68 more
core   +1 more source

Discovery, Herbicidal Activity and Biosynthesis of a Novel Natural Tetramic Acid from Alternaria Species

Advanced Science, Volume 12, Issue 21, June 5, 2025.
The biosynthetic mechanism of novel natural tetramic acid S‐TeA in Alternaria alternata is elucidated. Threonine acts as a precursor for 2‐amino‐3‐methylhexanoic acid (AMHA) synthesis via eight key enzymes from the branched‐chain amino acid biosynthetic pathway in the mitochondrion, wherein three unique enzymes (IPMS, IPMDH, and ISMD) play critical ...
He Wang, Yanjing Guo, Qing Liu, Jing Zhang, Qianlong Zhang, Mingying Yang, Qizhen Chen, Sheng Qiang, Bernal E. Valverde, Shiguo Chen   +9 more
wiley   +1 more source

Rational Design of Single‐Domain Antibodies Targeting the Central Nervous System Neurite Outgrowth Inhibitor Nogo‐A

Applied Research, Volume 4, Issue 3, June 2025.
The development of a nanobody for Nogo‐A, a potent neurite outgrowth inhibitor crucial in multiple sclerosis, is reported using a rational design approach. The nanobody targets the Nogo‐A ectodomain at the S1PR2 receptor‐binding region with submicromolar KD.
Vaidehi Roy Chowdhury, Alexander Röntgen, Matthew Greenig, Yanira Méndez Gómez, Sebastian P. Spiegel, Magdalena Nowinska, Aubin Ramon, Pietro Sormanni, Andrew Chan, Michele Vendruscolo   +9 more
wiley   +1 more source

Methionine-enkephalin-treatment suppresses the pituitary-ovary axis in the cichlid fish Oreochromis mossambicus

Aquaculture Reports, 2020
The involvement of endogenous opioid peptides in regulation of reproductive activity is implicated in a majority of vertebrates. Methionine-enkephalin (M-ENK) is an endogenous opioid peptide neurotransmitter produced in the central nervous system ...
C.B. Ganesh, Vijayalaxmi
doaj  

Evidence of Involvement of the Calcitonin Gene‐Related Peptide in Restless Legs Syndrome

Movement Disorders, Volume 40, Issue 6, Page 1148-1159, June 2025.
Abstract Background Restless legs syndrome (RLS) is a common sensory‐motor disorder characterized by an urge to move the legs, often with unpleasant sensations, particularly during rest. Current treatments include iron supplementation, dopamine agonists, and opioids, but new therapeutic approaches are needed.
Maria P. Mogavero, Mojibola Fowowe, Akeem Sanni, Mona Goli, Giuseppe Lanza, Francesca L'Episcopo, Luigi Ferini‐Strambi, Yehia Mechref, Raffaele Ferri   +8 more
wiley   +1 more source